Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates - Francica, Joseph R.; Laga, Richard; Lynn, Geoffrey M.; Mužíková, Gabriela; Androvič, Ladislav; Aussedat, Baptiste; Walkowicz, William E.; Padhan, Kartika; Ramirez-Valdez, Ramiro Andrei; Parks, Robert; Schmidt, Stephen D.; Flynn, Barbara J.; et al. (PLoS biology, 2019)
Keywords: Affinity; AIDS Vaccines - immunology; Animals; Antibodies, Neutralizing - immunology; Antibody Formation - immunology; Binding sites; Biocompatibility; Biology; Biology and Life Sciences; Cancer; Chemistry; Correlation analysis; Dendritic cells; Engineering and Technology; Epitopes; Epitopes - immunology; Female; Glycan; Glycoproteins; Health aspects; HIV; HIV (Viruses); HIV Envelope Protein gp120 - chemistry; HIV Infections - immunology; HIV Seropositivity - immunology; HIV-1 - immunology; Human immunodeficiency virus; Immune response; Immune system; Immunogenicity; Immunoglobulins; Immunology; Infections; Infectious diseases; Laboratories; Lymph nodes; Macaca mulatta; Macrophages; Medical research; Medicine and Health Sciences; Methacrylamide; Mice; Mice, Inbred BALB C; Monoclonal antibodies; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Neutralization; Neutralizing; Optimization; Peptides; Pharmacokinetics; Pharmacology; Physical characteristics; Physical properties; Polymers; Primates; Proteins; Research and Analysis Methods; Residential density; Supervision; Toll-like receptors; Trimers; Vaccination; Vaccines; Viral envelope proteins; United States; North Carolina; New York; Czech Republic; United States--US; Maryland