A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses

• Published in: PLoS pathogens Vol. 13; no. 3; p. e1006258
• Main Authors: Tripathi, Shashank, Balasubramaniam, Vinod R. M. T., Brown, Julia A., Mena, Ignacio, Grant, Alesha, Bardina, Susana V., Maringer, Kevin, Schwarz, Megan C., Maestre, Ana M., Sourisseau, Marion, Albrecht, Randy A., Krammer, Florian, Evans, Matthew J., Fernandez-Sesma, Ana, Lim, Jean K., García-Sastre, Adolfo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.03.2017; Public Library of Science (PLoS)
• Subjects: Abnormalities; Analysis; Animals; Aquatic insects; Biology and life sciences; Central nervous system; Cytokines; Disease; Disease Models, Animal; Disease susceptibility; Epidemics; Flavivirus; Global health; Gonads; Health aspects; Host-virus relationships; Immune response; Infections; Inflammation; Inflammation - immunology; Inflammation - virology; Inflammatory response; Interferon; Interrogation; Lethality; Life Sciences; Malfunctions; Medicine; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiology and Parasitology; Neurological diseases; Organs; Outbreaks; Pathogenesis; Pathogens; Phylogeny; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Signs and symptoms; Stem cells; Vector-borne diseases; Virology; Viruses; West Nile virus; Zika Virus; Zika Virus - genetics; Zika Virus - immunology; Zika Virus - pathogenicity; Zika Virus Infection; Zika Virus Infection - immunology; New York; United States > US

Zika virus (ZIKV) is a mosquito borne flavivirus, which was a neglected tropical pathogen until it emerged and spread across the Pacific Area and the Americas, causing large human outbreaks associated with fetal abnormalities and neurological disease in adults. The factors that contributed to the em...