The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D

• Published in: PLoS biology Vol. 21; no. 1; p. e3001693
• Main Authors: Kim, Hyejeong, Aponte-Diaz, David, Sotoudegan, Mohamad S., Shengjuler, Djoshkun, Arnold, Jamie J., Cameron, Craig E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.01.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Cytoplasm; DNA-directed RNA polymerase; Enterovirus - physiology; Enterovirus Infections - virology; Enteroviruses; Evolution; Genetic aspects; Genetic translation; Genomes; Host-Pathogen Interactions; Humans; Hypotheses; Identification and classification; Inactivation; Infections; Initiation factor eIF-2; Internal ribosome entry site; Internal Ribosome Entry Sites; Methods; Mutation; Peptide Initiation Factors - genetics; Polymerase chain reaction; Protein Biosynthesis; Recombination; Research and Analysis Methods; Ribonucleic acid; Ribosomes; RNA; RNA polymerase; RNA sequencing; RNA viruses; RNA, Viral - genetics; RNA, Viral - metabolism; RNA-directed RNA polymerase; Severe acute respiratory syndrome coronavirus 2; Vaccines; Viral infections; Viruses; United States; Netherlands

RNA recombination in positive-strand RNA viruses is a molecular-genetic process, which permits the greatest evolution of the genome and may be essential to stabilizing the genome from the deleterious consequences of accumulated mutations. Enteroviruses represent a useful system to elucidate the deta...