Structure of the post-translational protein translocation machinery of the ER membrane

• Published in: Nature (London) Vol. 566; no. 7742; pp. 136 - 139
• Main Authors: Wu, Xudong, Cabanos, Cerrone, Rapoport, Tom A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2019; Nature Publishing Group
• Subjects: 101/28; 631/535/1258/1259; 631/80/2023/2022; 82/1; 82/83; Adenosine triphosphatase; Binding sites; Biopolymers; Channel opening; Endoplasmic reticulum; Endoplasmic Reticulum - chemistry; Fungi; Heat shock proteins; Heat-Shock Proteins - chemistry; Heat-Shock Proteins - metabolism; Heat-Shock Proteins - ultrastructure; Hsp70 protein; Humanities and Social Sciences; Hydrophobicity; Letter; Lipids; Machinery; Membrane Glycoproteins - chemistry; Membrane Glycoproteins - metabolism; Membrane Glycoproteins - ultrastructure; Membrane proteins; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Membrane Proteins - ultrastructure; Membrane Transport Proteins - chemistry; Membrane Transport Proteins - metabolism; Membrane Transport Proteins - ultrastructure; Membranes; Microscopy; Models, Molecular; multidisciplinary; Physiological aspects; Polyethylene glycol; Polypeptides; Post-translation; Priming; Protein Binding; Protein Processing, Post-Translational; Protein structure; Protein Transport; Proteins; Resveratrol; Saccharomyces cerevisiae; Saccharomyces cerevisiae - chemistry; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - metabolism; Saccharomyces cerevisiae Proteins - ultrastructure; Science; Science (multidisciplinary); SEC Translocation Channels - chemistry; SEC Translocation Channels - metabolism; SEC Translocation Channels - ultrastructure; Signal recognition particle; Signal transduction; Structure; Substrates; Translation; Translocation

Many proteins must translocate through the protein-conducting Sec61 channel in the eukaryotic endoplasmic reticulum membrane or the SecY channel in the prokaryotic plasma membrane 1 , 2 . Proteins with highly hydrophobic signal sequences are first recognized by the signal recognition particle (SRP)...