A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen

• Published in: PLoS pathogens Vol. 20; no. 3; p. e1012128
• Main Authors: Su, Chia-Ming, Kim, Jineui, Tang, Junyu, Hung, Yu Fan, Zuckermann, Federico A., Husmann, Robert, Roady, Patrick, Kim, Jiyoun, Lee, Young-Min, Yoo, Dongwan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.03.2024; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Alveoli; Amino acids; Analysis; Animal diseases; Animals; antagonists; Antibodies; B cells; Bacteria; Bacterial infections; Betaarterivirus suid 2; Biological response modifiers; Biology and Life Sciences; Care and treatment; Chemokines; Coronaviruses; Cytokines; Diagnosis; disease severity; domain; Gene expression; Gene mutations; genes; Genetic aspects; genetic engineering; Genetic modification; Genetically modified organisms; Genetics; Genomes; Health aspects; Immunology; Infection; Infections; Inflammation; Interferon; interferons; Leucine; Livestock farms; Localization; Lymphocytes; Macrophages; Medical research; Medicine and Health Sciences; Medicine, Experimental; mixed infection; Mutants; Mutation; N gene; NF-κB protein; nuclear localization signals; nucleocapsid; Nucleocapsids; Pathogens; phenotype; Phenotypes; Porcine reproductive and respiratory syndrome; Pork industry; Proteins; Respiratory diseases; Respiratory tract diseases; reverse genetics; Signal transduction; Swine; vaccines; Viral diseases; Viral infections; viral nonstructural proteins; Viremia; Virus diseases; Viruses; β-Interferon; United States

Porcine reproductive and respiratory syndrome virus (PRRSV) is known to suppress the type I interferon (IFNs-α/β) response during infection. PRRSV also activates the NF-κB signaling pathway, leading to the production of proinflammatory cytokines during infection. In swine farms, co-infections of PRR...