A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen - Su, Chia-Ming; Kim, Jineui; Tang, Junyu; Hung, Yu Fan; Zuckermann, Federico A.; Husmann, Robert; Roady, Patrick; Kim, Jiyoun; Lee, Young-Min; Yoo, Dongwan (PLoS pathogens, 2024)
Keywords: Adaptive immunity; Alveoli; Amino acids; Analysis; Animal diseases; Animals; antagonists; Antibodies; B cells; Bacteria; Bacterial infections; Betaarterivirus suid 2; Biological response modifiers; Biology and Life Sciences; Care and treatment; Chemokines; Coronaviruses; Cytokines; Diagnosis; disease severity; domain; Gene expression; Gene mutations; genes; Genetic aspects; genetic engineering; Genetic modification; Genetically modified organisms; Genetics; Genomes; Health aspects; Immunology; Infection; Infections; Inflammation; Interferon; interferons; Leucine; Livestock farms; Localization; Lymphocytes; Macrophages; Medical research; Medicine and Health Sciences; Medicine, Experimental; mixed infection; Mutants; Mutation; N gene; NF-κB protein; nuclear localization signals; nucleocapsid; Nucleocapsids; Pathogens; phenotype; Phenotypes; Porcine reproductive and respiratory syndrome; Pork industry; Proteins; Respiratory diseases; Respiratory tract diseases; reverse genetics; Signal transduction; Swine; vaccines; Viral diseases; Viral infections; viral nonstructural proteins; Viremia; Virus diseases; Viruses; β-Interferon; United States