Acute dextran sulfate sodium (DSS)-induced colitis promotes gut microbial dysbiosis in mice

• Published in: Journal of basic microbiology Vol. 56; no. 9; pp. 986 - 998
• Main Authors: Munyaka, Peris Mumbi, Rabbi, Mohammad Fazle, Khafipour, Ehsan, Ghia, Jean-Eric
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.09.2016
• Subjects: Animals; Bacteria - isolation & purification; bacterial communities; Bacteroidaceae; Bacteroides; Base Sequence; Biodiversity; blood serum; C-reactive protein; C-Reactive Protein - metabolism; Clostridiaceae; Clostridium; Colitis; Colitis - chemically induced; Colitis - pathology; Colon - microbiology; Colon - pathology; community structure; dextran; Dextran Sulfate; Dextran sulfate sodium; Disease Models, Animal; disease severity; DNA; drinking water; Dysbiosis; Dysbiosis - pathology; Enterobacteriaceae; Escherichia; feces; Feces - microbiology; genes; inflammation; interleukin-1beta; Interleukin-1beta - blood; interleukin-6; Interleukin-6 - blood; intestinal microorganisms; Intestinal Mucosa - microbiology; Male; Mice; Mice, Inbred C57BL; Microbiota; mucosa; ribosomal RNA; RNA, Ribosomal, 16S - genetics; Sequence Analysis, DNA; sodium sulfate; species diversity; Microbiota; Mice; Colitis; Dysbiosis; Dextran sulfate sodium

The most widely used and characterized experimental model of ulcerative colitis (UC) is the epithelial erosion, dextran sulfate sodium (DSS)‐induced colitis, which is developed by administration of DSS in drinking water. We investigated fecal and colonic mucosa microbial composition and functional c...