Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women
Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine infl...
Saved in:
| Published in | PloS one Vol. 4; no. 12; p. e8300 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
15.12.2009
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria.
We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines.
Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65-7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P< or =0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P< or =0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004).
TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. |
|---|---|
| AbstractList | Background Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. Methodology We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. Principal Findings Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65-7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P[less than or equal to]0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P[less than or equal to]0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). Conclusions TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65-7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P< or =0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P< or =0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. Background Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. Methodology We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. Principal Findings Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65–7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P≤0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P≤0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). Conclusions TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. Background Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. Methodology We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. Principal Findings Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65–7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P≤0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P≤0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). Conclusions TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. Background Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. Methodology We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. Principal Findings Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65a7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (PaO0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (PaO0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). Conclusions TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. BACKGROUND:Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. METHODOLOGY:We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. PRINCIPAL FINDINGS:Polymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65-7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P< or =0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P< or =0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). CONCLUSIONS:TLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. BACKGROUNDAlthough several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria. METHODOLOGYWe conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of uropathogenic bacteria, neutrophils, and chemokines. PRINCIPAL FINDINGSPolymorphism TLR2_G2258A, a variant associated with decreased lipopeptide-induced signaling, was associated with increased ASB risk (odds ratio 3.44, 95%CI; 1.65-7.17). Three CXCR1 polymorphisms were associated with ASB caused by gram-positive organisms. ASB was associated with urinary CXCL-8 levels, but not CXCL-5, CXCL-6, or sICAM-1 (P< or =0.0001). Urinary levels of CXCL-8 and CXCL-6, but not ICAM-1, were associated with higher neutrophil levels (P< or =0.0001). In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004). CONCLUSIONSTLR2 and CXCR1 polymorphisms were associated with ASB and a CXCR1 variant was associated with urine CXCL-8 levels. These results suggest that genetic factors are associated with early in vivo human bladder immune responses prior to the development of symptomatic UTIs. |
| Audience | Academic |
| Author | Stapleton, Ann E Stamm, Walter E Hawn, Thomas R Li, Sue S Zhao, Lue Ping Scholes, Delia Janer, Marta Aderem, Alan Wang, Hongwei Hooton, Thomas M |
| AuthorAffiliation | 5 Department of Medicine, University of Miami, Miami, Florida, United States of America New York University, United States of America 1 Department of Medicine, University of Washington, Seattle, Washington, United States of America 3 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America 4 Institute for Systems Biology, Seattle, Washington, United States of America 2 Group Health Center for Health Studies, Group Health Cooperative, and Department of Epidemiology, University of Washington, Seattle, Washington, United States of America |
| AuthorAffiliation_xml | – name: 2 Group Health Center for Health Studies, Group Health Cooperative, and Department of Epidemiology, University of Washington, Seattle, Washington, United States of America – name: 4 Institute for Systems Biology, Seattle, Washington, United States of America – name: 1 Department of Medicine, University of Washington, Seattle, Washington, United States of America – name: 5 Department of Medicine, University of Miami, Miami, Florida, United States of America – name: New York University, United States of America – name: 3 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America |
| Author_xml | – sequence: 1 givenname: Thomas R surname: Hawn fullname: Hawn, Thomas R email: thawn@u.washington.edu organization: Department of Medicine, University of Washington, Seattle, Washington, USA. thawn@u.washington.edu – sequence: 2 givenname: Delia surname: Scholes fullname: Scholes, Delia – sequence: 3 givenname: Hongwei surname: Wang fullname: Wang, Hongwei – sequence: 4 givenname: Sue S surname: Li fullname: Li, Sue S – sequence: 5 givenname: Ann E surname: Stapleton fullname: Stapleton, Ann E – sequence: 6 givenname: Marta surname: Janer fullname: Janer, Marta – sequence: 7 givenname: Alan surname: Aderem fullname: Aderem, Alan – sequence: 8 givenname: Walter E surname: Stamm fullname: Stamm, Walter E – sequence: 9 givenname: Lue Ping surname: Zhao fullname: Zhao, Lue Ping – sequence: 10 givenname: Thomas M surname: Hooton fullname: Hooton, Thomas M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20016852$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk11rFDEUhgep2A_9B6IDQsWLXfO1SeZGKEXrQqHg1204M3OymzKTrMlMtf_ejLstXRGRXCScPO8bzjk5x8WBDx6L4jklc8oVfXsdxuihm29yeE4I0ZyQR8URrTibSUb4wYPzYXGc0jUhC66lfFIcMkKo1At2VLgL9Di4pryB6GBwwZfBlsMay_XYgy_H6DzE23KI0Ayl8x4GLF3fjx7LiCk_nrAE35aQbvvNEHqYzOoMY3RZDFlT_gg9-qfFYwtdwme7_aT4-uH9l_OPs8uri-X52eWskZUYZsiFlNTWgqCymrcLRSg2dQ01r6FqGZXC0rYFK-WiIUy3nILGfFbcYm0rflK83PpuupDMrkrJUFZRXUlWTcRyS7QBrs0muj5naAI48zsQ4spAzGl0aATRGq1mBGklWgUVF2JRgyWika1tmuz1bvfaWPfYNuhzpbo90_0b79ZmFW4MU1qr3JCT4vXOIIbvI6bB9C412HXgMYzJKJ6bzRUTmTz9J8mokFyRCXz1B_j3Ksy31Apyos7bMPU4rxZ71-RPZV2OnwnFlGSCsCx4syfIzIA_hxWMKZnl50__z15922dPH7BrhG5Yp9CN02dM-6DYgk0MKUW092WmxEwzcZenmWbC7GYiy148bNG96G4I-C8aegt1 |
| CitedBy_id | crossref_primary_10_1128_microbiolspec_UTI_0002_2012 crossref_primary_10_1007_s11908_011_0212_x crossref_primary_10_1038_nrurol_2011_192 crossref_primary_10_1016_j_jmb_2019_11_008 crossref_primary_10_1186_s12979_019_0156_9 crossref_primary_10_1371_journal_pone_0010734 crossref_primary_10_1016_j_idc_2013_09_005 crossref_primary_10_1016_j_idc_2013_09_003 crossref_primary_10_1038_nrurol_2013_153 crossref_primary_10_1089_sur_2018_201 crossref_primary_10_4049_jimmunol_1401528 crossref_primary_10_1016_j_micinf_2011_04_007 crossref_primary_10_1080_00480169_2019_1689196 crossref_primary_10_1038_s41585_021_00477_x crossref_primary_10_1007_s11481_013_9483_3 crossref_primary_10_1371_journal_pone_0058687 crossref_primary_10_1186_1471_2334_13_213 crossref_primary_10_3390_ijtm2010006 crossref_primary_10_1016_j_idc_2013_10_006 crossref_primary_10_1038_s41585_022_00602_4 crossref_primary_10_1128_IAI_00745_15 crossref_primary_10_1371_journal_pone_0140128 crossref_primary_10_1007_s00345_018_2206_x crossref_primary_10_1093_cid_cis534 crossref_primary_10_1111_j_1744_313X_2012_01096_x crossref_primary_10_1111_nep_13260 crossref_primary_10_1089_jir_2012_0140 crossref_primary_10_1038_mi_2013_72 crossref_primary_10_1016_j_gene_2017_10_060 crossref_primary_10_1128_microbiolspec_UTI_0001_2012 crossref_primary_10_2165_11538050_000000000_00000 crossref_primary_10_1371_journal_pone_0028289 crossref_primary_10_2217_epi_12_5 crossref_primary_10_1111_nyas_12763 crossref_primary_10_1128_microbiolspec_UTI_0019_2014 crossref_primary_10_1038_nrurol_2017_25 crossref_primary_10_1097_INF_0b013e3181ff84ff crossref_primary_10_1093_cid_civ696 crossref_primary_10_1016_j_juro_2017_01_070 crossref_primary_10_1128_mBio_00066_11 crossref_primary_10_3389_fmicb_2023_1093922 crossref_primary_10_2196_resprot_9514 crossref_primary_10_1038_s41598_017_10445_4 crossref_primary_10_3390_medicina58060750 crossref_primary_10_1111_sji_12818 crossref_primary_10_1007_s00467_011_2089_1 crossref_primary_10_1038_nrneph_2014_91 crossref_primary_10_1177_1933719116667489 crossref_primary_10_1038_nrurol_2011_100 crossref_primary_10_1038_nrurol_2010_190 crossref_primary_10_1093_infdis_jis558 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2009 Public Library of Science 2009 Hawn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Hawn et al. 2009 |
| Copyright_xml | – notice: COPYRIGHT 2009 Public Library of Science – notice: 2009 Hawn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Hawn et al. 2009 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PIMPY PQEST PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0008300 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale In Context: Opposing Viewpoints database Science in Context ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing and Allied Health Journals Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (Proquest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Publicly Available Content (ProQuest) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic Technology Collection Technology Research Database Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database Genetics Abstracts MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine |
| DocumentTitleAlternate | Polymorphisms and ASB |
| EISSN | 1932-6203 |
| Editor | Unutmaz, Derya |
| Editor_xml | – sequence: 1 givenname: Derya surname: Unutmaz fullname: Unutmaz, Derya |
| EndPage | e8300 |
| ExternalDocumentID | 1291896299 oai_doaj_org_article_4088ef820e194d7a93445baf04c6dfcc 2897850231 A472762402 10_1371_journal_pone_0008300 20016852 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States--US |
| GeographicLocations_xml | – name: United States--US |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: P01 DK053369 – fundername: NIDDK NIH HHS grantid: R01 DK062863 – fundername: NIDDK NIH HHS grantid: 2P01 DK53369-11 |
| GroupedDBID | --- 123 29O 2WC 3V. 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV ADRAZ AEAQA AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CGR CS3 CUY CVF D1I D1J D1K DIK DU5 E3Z EAP EAS EBD ECM EIF EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ NPM O5R O5S OK1 P2P P62 PATMY PDBOC PIMPY PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX CITATION AFPKN 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PQEST PQUKI PRINS RC3 7X8 5PM - 02 AAPBV ABPTK ADACO B0M BBAFP KM |
| ID | FETCH-LOGICAL-c694t-e34661fb40e7f83d5701ecbbab3ba9d2164f1ddaf665c028d31a8e65c73febf93 |
| IEDL.DBID | RPM |
| ISSN | 1932-6203 |
| IngestDate | Sun Jun 05 00:11:05 EDT 2022 Tue Oct 22 15:14:06 EDT 2024 Tue Sep 17 21:18:48 EDT 2024 Fri Oct 25 10:19:14 EDT 2024 Fri Oct 25 22:38:43 EDT 2024 Thu Oct 10 15:53:24 EDT 2024 Wed Nov 13 00:55:05 EST 2024 Thu Aug 01 19:23:30 EDT 2024 Thu Aug 01 19:41:46 EDT 2024 Tue Aug 20 22:04:35 EDT 2024 Thu Nov 21 21:19:45 EST 2024 Wed Oct 16 00:48:32 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c694t-e34661fb40e7f83d5701ecbbab3ba9d2164f1ddaf665c028d31a8e65c73febf93 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Conceived and designed the experiments: TRH DS SL AS AA WES LPPZ TMH. Performed the experiments: TRH MJ. Analyzed the data: TRH DS HW SL AS MJ AA LPPZ TMH. Wrote the paper: TRH DS HW SL AS MJ AA WES LPPZ TMH. |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788705/ |
| PMID | 20016852 |
| PQID | 1291896299 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1291896299 doaj_primary_oai_doaj_org_article_4088ef820e194d7a93445baf04c6dfcc pubmedcentral_primary_oai_pubmedcentral_nih_gov_2788705 proquest_miscellaneous_733713724 proquest_miscellaneous_21463704 proquest_journals_1291896299 gale_infotracacademiconefile_A472762402 gale_incontextgauss_ISR_A472762402 gale_incontextgauss_IOV_A472762402 gale_healthsolutions_A472762402 crossref_primary_10_1371_journal_pone_0008300 pubmed_primary_20016852 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-12-15 |
| PublicationDateYYYYMMDD | 2009-12-15 |
| PublicationDate_xml | – month: 12 year: 2009 text: 2009-12-15 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2009 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| SSID | ssj0053866 |
| Score | 2.2909312 |
| Snippet | Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine... Background Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in... BACKGROUNDAlthough several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in... BACKGROUND:Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in... Background Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in... |
| SourceID | plos doaj pubmedcentral proquest gale crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | e8300 |
| SubjectTerms | Adult Age Bacteria Bacteriuria Bacteriuria - genetics Bacteriuria - immunology Bacteriuria - microbiology Bacteriuria - urine Bladder Borrelia burgdorferi Cancer Chemokines Chemokines - urine CXCR2 protein Demography Deoxyribonucleic acid DNA Female Gene polymorphism Genes Genetic aspects Genetic diversity Genetic factors Genetic polymorphisms Genetic Variation Gram-Negative Bacteria - physiology Health risk assessment Human behavior Humans Immune response Immune system Immunity, Innate - genetics Immunology/Genetics of the Immune System Immunology/Innate Immunity Infectious Diseases/Urological Infections Inflammation Innate immunity Intercellular adhesion molecule 1 Interleukin-8 - urine Kidney diseases Leprosy Leukocytes (neutrophilic) Lyme disease Medical research Medicine Neutrophils Neutrophils - cytology Pathogenesis Polymorphism Polymorphism, Single Nucleotide - genetics Population studies Pyelonephritis Receptors, Interleukin-8A - genetics Receptors, Interleukin-8B - genetics Risk factors Sepsis Signal transduction Signaling Studies TLR1 protein TLR2 protein TLR4 protein TLR5 protein Toll-Like Receptor 2 - genetics Toll-like receptors Tuberculosis Urinary bladder Urinary tract Urinary Tract - immunology Urinary Tract - microbiology Urinary tract diseases Urinary tract infections Urine Urine - cytology Urogenital system Women Womens health |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyquBQi2EBBzSJrETJ8eCqAoSIAFFvVl-lpUgWW2ySP33zDjeaIOK4MAtiidSMjO2v8nMfCbkWeFEUSjDU1Fzk3KmedoYTPJaZlWhMDGGgeL7D9XZOX93UV7sHPWFNWEjPfCouGMO08B52KcchNtWqIZxXmrlM24q640Jq29WbIOpcQ2GWVxVsVGOifw42uVo1bXuKMAO7Gjb2YgCX_-0Ki9W37v-Osj5e-XkzlZ0epvcihiSnozvvkduuPYO2YuztKcvIpX0y7tkiZcgRX9CSBxsQDtPAfPRcDYfxV_tan1FB-yVosu2BeRJl9gy4uh6rJ51VLWWqv7qx2roAr8r1SPDMzys4BkaSBzukfPTN19en6XxcIXUVA0fUsc4bM1e88wJXzNbiix3RmulmVaNLSCM8rm1yldVaQCEWJar2sG1YN5p37D7ZNGCOvcJhQgbUILlnBcZV84B5uTecAHgUzPBbELSrablauTQkCGRJiD2GFUm0TIyWiYhr9AckywyYIcb4Bcy-oX8m18k5BCNKcd20mkeyxMOiK3CnFJCngYJZMFosczmUm36Xr79-PUfhD5_mgk9j0K-Q4Op2NoA34TsWjPJffSt7Wf3EuBWXjcVgIKEHGz97frhw2kYVgBM66jWdZte4tHsTGQ8IfQPEoKBqpkoQOTB6L-TbrGkrqpLeDEx8-yZ8ucj7fJboCEvsBA1Kx_-D2s9IjeLeDBHXh6QxbDeuMeA9gb9JEzsXwwyVSU priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSIgXxMbHMgazEBLwkC2JHTt5Qh2irEgDaazT3iLHH1sllpSmfeC_585xy4oG4i2KL1Fydz7_7Psi5HVmZZYpzWNZcB1zVvO41OjkNcyoTKFjDDeKJ1_E8YR_vsgvwoFbF8IqVzbRG2rTajwjP4R1KS1KAdbz_exHjF2j0LsaWmjcJffSTAoM6StGn1aWGOayECFdjsn0MEjnYNY29sCDD8xru7Ec-ar9a9s8mH1vu9uA55_xkzcWpNEj8jAgSTrsRb9F7thmm9w_Cb7ybbIVpm1H34ba0u8ekylewgP0HPbIXii0dRRAIPWn-XQy9_m59AyTp-i4aQCK0jHmkFh62ofTWqoaQ4fdz-vZovUFX-lRX_J5Ca-k04b6rphPyGT08ezDcRy6LcRalHwRW8ZhrXY1T6x0BTO5TFKr61rVrFalyWBf5VJjlBMi14BKDEtVYeFaMmdrV7KnZNAAZ3cIhS03wAbDOc8SrqwFEMqd5hLQaM0kMxGJV0yvZn1Rjcp71iRsRnruVSikKggpIkcomTUtlsT2N9r5ZRVmWMXBXloHgMamJTdSlYzzvFYu4VoYp3VE9lGuVZ9fup7Y1ZADhBPoZIrIK0-BZTEajLu5VMuuq8Zfz_-D6NvpBtGbQORa0BCtQq4D_BOW29qg3EE1W_12V_3W84jsrVTv9uH99TCYBPTzqMa2y67CXu1MJjwi9C8UkgGrmcyA5FmvymveYoydKHL4MLmh5BvM3xxpple-LnmGkalJvvvv735OHmShB0ea75HBYr60LwDYLeqXfvb-ArySTj0 priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9RAEF_KFcQXsfWjsdUuIqgPOZLsJHt5ELmKpSecQu2VvoXNfrQHNTkvd2D_e2c3e8HIVXwL2dmQzM7s_ibzRcibRPMkERJCPgIZAishzKV18iqmRCKsY8waitOv2dkMvlylVztk07PVM7DZatrZflKz5e3w18-7j6jwH1zXBh5vJg0XdaWHDlREaMTvJng22iCvKXR-BdTuLPMJdPfN7B1Qro5_t1sPFrd1sw2K_h1R-ccRdfqYPPLYko5bYdgjO7raJw-m3nu-T_a8Ijf0na82_f4JmdtLnEAv0Wp2y0RrQxEWUvd_n86WLmOXXth0KjqpKgSndGKzSjQ9bwNsNRWVouPm7sdiVbsSsPSkLQK9xkfSeUVdn8ynZHb6-eLTWej7L4Qyy2EVagZ4epsSIs3NiKmUR7GWZSlKVopcJWhpmVgpYbIslYhTFIvFSOM1Z0aXJmfPyKBCzh4QikY4AgkFAEkEQmuEpWAkcMSnJeNMBSTcML1YtGU2Cudr42ietNwr7CIVfpECcmJXpqO1RbLdjXp5XXidKwB3UG0Q4ug4B8VFzgDSUpgIZKaMlAE5tutatBmnnaoXY0BQl1m3U0BeOwpbKKOykTjXYt00xeTb5X8QfT_vEb31RKZGCZHCZz_gN9kCXD3KAytmm89uCkRk8SjPEDcE5GgjetuHj7th3CSs50dUul43he3ezngEAaH3UHCGrGY8QZLnrSh3vLVRd9koxRfjPSHvMb8_Us1vXKXyxMaqRumLf7_3IXmY-K4ccXpEBqvlWr9EqLcqXznt_Q2RKlP5 priority: 102 providerName: Scholars Portal |
| Title | Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/20016852 https://www.proquest.com/docview/1291896299 https://search.proquest.com/docview/21463704 https://search.proquest.com/docview/733713724 https://pubmed.ncbi.nlm.nih.gov/PMC2788705 https://doaj.org/article/4088ef820e194d7a93445baf04c6dfcc http://dx.doi.org/10.1371/journal.pone.0008300 |
| Volume | 4 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2cuGCGF8LjM5CSMAhbRI7cXJsq5UVqWMq69Rb5Phjq7QmVdMe-O95dpyKoiEhLlZUv1TJ-7B_L-_DCH2MFIsiLqjPUip8SgrqZ8IEeSWRPOImMGYcxelVcjmn3xbx4gjFbS2MTdoXxbJXPqx65fLe5lauV6Lf5on1r6ejyKTABXH_GB3D9tu66M3yCwacJK5GjrCw70TSW1el6lnEEZjT30wqUZLG0cF2ZLv279fmzvqhqh8Dnn_mT_62IY2fo2cOSeJB88Qn6EiVL9CJs9Uaf3YNpb-8REtzCVT4FhxjKwlcaQzID9tP-Hi-sUW5-MZUTOFJWQL-xBNTOKLwrMmhVZiXEg_qn6v1trJdXvGw6fO8g7_EyxLbozBfofn44mZ06bsjFnyRZHTrK0Jhg9YFDRTTKZExC0IlioIXpOCZjMCZ0qGUXCdJLACKSBLyVME1I1oVOiOvUacEzp4iDH42YAVJKY0CypUC5Em1oAwgaEEYkR7yW07n66aTRm7DaQw8kIZluRFS7oTkoaERx57W9MG2P1Sbu9xpQ05hkVQaUIwKMyoZzwilccF1QEUitRAeOjfCzJui0r015wMKipOYyJKHPlgK0wujNMk2d3xX1_nk--0_EP2YHRB9ckS6ArUQ3BU4wDuZHlsHlKdGt9rXrnMAXWGaJQANPHTW6tvj0-f7aVgHTHCHl6ra1bk5oJ2wgHoI_4WCEWA1YRGQvGn0d8_b1ho8xA40-4D5hzNgm7YZubPFt_995zv0NHJncoTxGepsNzv1HoDetuiCeS8YjOkoNOP4axc9GV5cXc-69tMJjFOadq35_wK6L1nm |
| link.rule.ids | 230,314,727,780,784,864,885,2102,2221,12056,12223,12765,21388,24318,27924,27925,31719,31720,33266,33267,33373,33374,33744,33745,43310,43579,43600,43805,53791,53793,73745,74014,74035,74302 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegk4AXxMbHAoNaCAl4yNbETtw8oRZtamEtqLTT3izHdkYlSErTPvDfc-e4ZUUD8RbFlyi5O59_9n0R8iq2Io6V5qHoch1ylvMw0-jkNcyoWKFjDDeKo3E6mPEPl8mlP3CrfVjlxiY6Q20qjWfkJ7AuRd0sBev5bvEjxK5R6F31LTRukz2snJ60yF7_dPx5srHFMJvT1CfMMRGdePkcL6rSHjv4gZlt1xYkV7d_a51bi29VfRP0_DOC8tqSdPaA3PdYkvYa4e-TW7Y8IHdG3lt-QPb9xK3pG19d-u1DMsdLeIBewC7ZiYVWBQUYSN15Pp0tXYYunWL6FB2WJYBROsQsEksnTUCtpao0tFf__L5YVa7kK-03RZ_X8Eo6L6nri_mIzM5Op-8Hoe-3EOo046vQMg6rdZHzjhVFl5lEdCKr81zlLFeZiWFnVUTGqCJNEw24xLBIdS1cC1bYvMjYY9IqgbOHhMKmG4CD4ZzHHa6sBRjKC80F4NGcCWYCEm6YLhdNWQ3pfGsCtiMN9yQKSXohBaSPktnSYlFsd6NaXkk_xyQHi2kLgDQ2yrgRKmOcJ7kqOlynptA6IG2Uq2wyTLdTW_Y4gLgU3UwBeekosDBGiZE3V2pd13L46eI_iL5Mdohee6KiAg3Rymc7wD9hwa0dykNUs81v1_K3pgfkaKN6Nw-3t8NgFNDTo0pbrWuJ3dqZ6PCA0L9QCAasZiIGkieNKm95i1F2aTeBDxM7Sr7D_N2Rcv7VVSaPMTa1kzz993e3yd3BdHQuz4fjj8_Ivdh35IiSI9JaLdf2OcC8Vf7Cz-VfHvJSjg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLagkyZeJjYuCwxqISTgIWsSO3HzhFpYtQIrU1mnvVmOL6MSJKFpH_j3HDtuWdFAvEX1SZWcmz_n3BB6mWiWJELSkPWpDCkpaJhLG-RVRIlE2MCYPSieTbLTGf1wlV75_KfGp1WufaJz1KqS9ht5D_aluJ9n4D17xqdFnL8fva1_hHaClI20-nEad9EO7IpR0kE7w5PJ-XTtl8Gys8wXzxEW97ysjuuq1McOitgqtxubk-vhv_HUnfpb1dwGQ__MpryxPY3uoz2PK_GgVYR9dEeXB2j3zEfOD9C-N-IGv_adpt88QHN7CTfgSzgxOxHhymCAhNh928ezhavWxRe2lAqPyxKAKR7bihKNp21yrcaiVHjQ_PxeLyvX_hUP2wbQK_hLPC-xm5H5EM1GJxfvTkM_eyGUWU6XoSYUdm5T0Egz0ycqZVGsZVGIghQiVwmcskyslDBZlkrAKIrEoq_hmhGjC5OTR6hTAmcPEYYDOIAIRSlNIiq0BkhKjaQMsGlBGFEBCtdM53XbYoO7OBuDo0nLPW6FxL2QAjS0ktnQ2gbZ7odqcc29vXEK3lMbgDc6zqliIieUpoUwEZWZMlIGqGvlyttq042Z8wEFQJfZkFOAXjgK2ySjtOp2LVZNw8efL_-D6Mt0i-iVJzIVaIgUvvIB3sk239qiPLRqtn7thv_W-gAdrVXv9uXuZhkchI36iFJXq4bbye2ERTRA-C8UjACrCUuA5HGryhve2oy7rJ_Cg7EtJd9i_vZKOf_qupQnNk81Sp_8-7m7aBfMmH8aTz4-RfcSP5wjTo9QZ7lY6WeA-JbFc2_KvwD_b1a7 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+Variation+of+the+Human+Urinary+Tract+Innate+Immune+Response+and+Asymptomatic+Bacteriuria+in+Women&rft.jtitle=PloS+one&rft.au=Hawn%2C+Thomas+R&rft.au=Scholes%2C+Delia&rft.au=Wang%2C+Hongwei&rft.au=Li%2C+Sue+S&rft.date=2009-12-15&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=4&rft.issue=12&rft.spage=e8300&rft_id=info:doi/10.1371%2Fjournal.pone.0008300&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=2897850231 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |