Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis

• Published in: PLoS genetics Vol. 19; no. 8; p. e1010875
• Main Authors: Kilwein, Marcus D, Dao, T Kim, Welte, Michael A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.08.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Cell organelles; Cytoskeleton; Drosophila; Embryogenesis; Embryonic development; Embryos; Epithelium; Glutathione; Glycogen; Growth; Hatching; Homeostasis; Identification and classification; Insects; Lipid metabolism; Lipid peroxidation; Lipids; Metabolism; Mollusks; Mutants; Mutation; Organelles; Oxidative stress; Physiological aspects; Proteins; Proteomes; Research and Analysis Methods; Transcriptomes; Triglycerides; United States

Lipid droplets (LDs) are ubiquitous organelles that facilitate neutral lipid storage in cells, including energy-dense triglycerides. They are found in all investigated metazoan embryos where they are thought to provide energy for development. Intriguingly, early embryos of diverse metazoan species a...