In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis

• Published in: PLoS pathogens Vol. 12; no. 3; p. e1005469
• Main Authors: Bell, Lucy C K, Pollara, Gabriele, Pascoe, Mellissa, Tomlinson, Gillian S, Lehloenya, Rannakoe J, Roe, Jennifer, Meldau, Richard, Miller, Robert F, Ramsay, Alan, Chain, Benjamin M, Dheda, Keertan, Noursadeghi, Mahdad
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2016; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; Aged; AIDS; Biology and Life Sciences; Biomedical research; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - immunology; Computational Biology; Drug therapy; Female; Gene expression; Gene Expression Profiling; Health aspects; Highly active antiretroviral therapy; HIV; HIV Infections - complications; HIV Infections - immunology; HIV Infections - pathology; HIV Seropositivity; HIV-1 - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immune Reconstitution Inflammatory Syndrome - immunology; Immunology; Infections; Interferon Type I - immunology; Interleukin-10 - immunology; Investigations; Male; Medicine and Health Sciences; Middle Aged; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - immunology; Risk factors; Tuberculosis; Tuberculosis - complications; Tuberculosis - immunology; Tuberculosis - pathology; Tuberculosis - virology; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - pathology; Tuberculosis, Pulmonary - virology; Young Adult

Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 responses, indicating that these are not sufficient to protect against disease. Recent findings suggest that favour...