Perioperative administration of sub-anesthetic ketamine/esketamine for preventing postpartum depression symptoms: A trial sequential meta-analysis

• Published in: PloS one Vol. 19; no. 11; p. e0310751
• Main Authors: Hung, Kuo-Chuan, Kao, Chia-Li, Lai, Yi-Chen, Chen, Jen-Yin, Lin, Chien-Hung, Ko, Ching-Chung, Lin, Chien-Ming, Chen, I-Wen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.11.2024; Public Library of Science (PLoS)
• Subjects: Anesthesia; Antidepressants; Bias; Biology and Life Sciences; Depression, Postpartum - prevention & control; Dosage; Dosage and administration; Drug dosages; Female; Humans; Intervention; Ketamine; Ketamine - administration & dosage; Ketamine - therapeutic use; Medicine and Health Sciences; Mental depression; Meta-analysis; People and Places; Perioperative care; Perioperative Care - methods; Pharmacology, Experimental; Physical Sciences; Physiological aspects; Postpartum; Postpartum depression; Prevention; Randomized Controlled Trials as Topic; Reliability; Research and Analysis Methods; Science Policy; Sequential analysis; Social Sciences; Subgroups; Testing; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0310751

Postpartum depression (PPD) is a major mental health issue affecting 10%-15% of women globally. This meta-analysis synthesized updated evidence on sub-anesthetic ketamine/esketamine's efficacy in preventing PPD. Randomized controlled trials (RCTs) comparing ketamine/esketamine to a placebo for...