Neural substrates of normal and impaired preattentive sensory discrimination in large cohorts of nonpsychiatric subjects and schizophrenia patients as indexed by MMN and P3a change detection responses

• Published in: NeuroImage (Orlando, Fla.) Vol. 66; pp. 594 - 603
• Main Authors: Takahashi, Hidetoshi, Rissling, Anthony J., Pascual-Marqui, Roberto, Kirihara, Kenji, Pela, Marlena, Sprock, Joyce, Braff, David L., Light, Gregory A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Adult and adolescent clinical studies; Attention - physiology; Biological and medical sciences; Biomarkers; Brain - physiopathology; Cognition; Cohort Studies; Discrimination; EEG; Electroencephalography; Endophenotype; Evoked Potentials - physiology; Female; Humans; Illnesses; Light; LORETA; Male; Medical sciences; Mental disorders; Middle Aged; Mismatch negativity; MMN; P300; P3a; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - physiopathology; Sensory information processing; Signal Processing, Computer-Assisted; Source localization; Studies; Mismatch negativity; Source localization; EEG; P300; Schizophrenia; Sensory information processing; Cognition; LORETA; Endophenotype; MMN; P3a; Human; Stimulus disparity; Electrophysiology; Electroencephalography; P300 potential; Psychosis; Discrimination; Acoustic stimulus; Auditory evoked potential; Information processing; Localization

Schizophrenia (SZ) patients have information processing deficits, spanning from low level sensory processing to higher-order cognitive functions. Mismatch negativity (MMN) and P3a are event-related potential (ERP) components that are automatically elicited in response to unattended changes in ongoin...