Characterization of the Conus bullatus genome and its venom-duct transcriptome

Background The venomous marine gastropods, cone snails (genus Conus ), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have prov...

Full description

Saved in:
Bibliographic Details
Published inBMC genomics Vol. 12; no. 1; p. 60
Main Authors Hu, Hao, Bandyopadhyay, Pradip K, Olivera, Baldomero M, Yandell, Mark
Format Journal Article
LanguageEnglish
Published London BioMed Central 25.01.2011
BioMed Central Ltd
BMC
Subjects
Amino acids
Animal Genetics and Genomics
Animals
Base Composition - genetics
Biomedical and Life Sciences
Cone snails
Conus Snail - genetics
Gene Expression Profiling
Genetic aspects
Genome - genetics
Genomes
Genomics
Life Sciences
Microarrays
Microbial Genetics and Genomics
Molecular Sequence Annotation
Mollusk Venoms - genetics
Multicellular invertebrate genomics
Peptides
Peptides - genetics
Pharmacology
Physiological aspects
Plant Genetics and Genomics
Proteomics
Reagents
Research Article
RNA
Single nucleotide polymorphisms
Software
Studies
Venom
United States
Ziconotide
Transcriptome Assembly
Estimate Genome Size
Simple Repeat
Repeat Content
Online AccessGet full text
ISSN1471-2164
1471-2164
DOI10.1186/1471-2164-12-60

Cover

Abstract Background The venomous marine gastropods, cone snails (genus Conus ), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia , whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade. Results We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities. Conclusions Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
AbstractList Abstract Background: The venomous marine gastropods, cone snails (genus Conus ), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia , whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade. Results: We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities. Conclusions: Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia, whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade. We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities. Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia, whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade.BACKGROUNDThe venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia, whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade.We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities.RESULTSWe have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities.Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.CONCLUSIONSOur results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
Background The venomous marine gastropods, cone snails (genus Conus ), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia , whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade. Results We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities. Conclusions Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia, whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade. We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities. Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter. Over the last decade, conopeptides have proven indispensable reagents for the study of vertebrate neurotransmission. Conus bullatus belongs to a clade of Conus species called Textilia, whose pharmacology is still poorly characterized. Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade. Results We have carried out a sequencing survey of the Conus bullatus genome and venom-duct transcriptome. We find that conopeptides are highly expressed within the venom-duct, and describe an in silico pipeline for their discovery and characterization using RNA-seq data. We have also carried out low-coverage shotgun sequencing of the genome, and have used these data to determine its size, genome-wide base composition, simple repeat, and mobile element densities. Conclusions Our results provide the first global view of venom-duct transcription in any cone snail. A notable feature of Conus bullatus venoms is the breadth of A-superfamily peptides expressed in the venom duct, which are unprecedented in their structural diversity. We also find SNP rates within conopeptides are higher compared to the remainder of C. bullatus transcriptome, consistent with the hypothesis that conopeptides are under diversifying selection.
ArticleNumber 60
Audience Academic
Author Bandyopadhyay, Pradip K
Olivera, Baldomero M
Hu, Hao
Yandell, Mark
AuthorAffiliation 2 Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
1 Eccles institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT 84112, USA
AuthorAffiliation_xml – name: 2 Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
– name: 1 Eccles institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT 84112, USA
Author_xml – sequence: 1
  givenname: Hao
  surname: Hu
  fullname: Hu, Hao
  organization: Eccles institute of Human Genetics, University of Utah, and School of Medicine
– sequence: 2
  givenname: Pradip K
  surname: Bandyopadhyay
  fullname: Bandyopadhyay, Pradip K
  organization: Department of Biology, University of Utah
– sequence: 3
  givenname: Baldomero M
  surname: Olivera
  fullname: Olivera, Baldomero M
  organization: Department of Biology, University of Utah
– sequence: 4
  givenname: Mark
  surname: Yandell
  fullname: Yandell, Mark
  email: myandell@genetics.utah.edu
  organization: Eccles institute of Human Genetics, University of Utah, and School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21266071$$D View this record in MEDLINE/PubMed
BookMark eNp1kktv1DAUhSNURB-wZociWCAWaa8fseNNpWrEY6QKJB5ry3GcjEcZe7CdCvj1OJ22dCqqLGLffOfYOTrHxYHzzhTFSwSnCDXsDFGOKowYrRCuGDwpju4mB_fWh8VxjGsAxBtcPysOMcKMAUdHxefFSgWlkwn2j0rWu9L3ZVqZcuHdFMt2GkeV8mIwzm9MqVxX2hTLq3lbdZNOZQrKRR3sNmXgefG0V2M0L27eJ8WPD--_Lz5Vl18-LhcXl5VmgqSqRZzUoia8xVxh3TUADHd503Q9JogDQz0FYXoNpO4b3HWCa8xrAwL1HBQ5KZY7386rtdwGu1Hht_TKyuuBD4NUIVk9GkmFoE3DGBUKqCKsaUxnCIG2rlvKepS9znde26ndmE4bl39p3DPd_-LsSg7-ShKgwDHPBm9vDIL_OZmY5MZGbXJyzvgpyqbGAoRAkMnXD8i1n4LLSUkBGEiDMM3Qmx00qHx963qfT9WzpbzAVBCKAZpMnf6Hyk9nNlbnlvQ2z_cE7_YEmUnmVxrUFKNcfvu6z766H8ldFre9yUC9A3TwMQbTS23TdX_yLewoEci5n3JuoJwbKBGWbA7g7IHu1vpxBewUMZNuMOFfZI9J_gKGRvEt
CitedBy_id crossref_primary_10_1073_pnas_1423857112
crossref_primary_10_1016_j_toxicon_2024_108087
crossref_primary_10_3390_md11062069
crossref_primary_10_3390_toxins13040270
crossref_primary_10_1371_journal_pone_0094098
crossref_primary_10_1038_s41421_021_00244_7
crossref_primary_10_1186_s13742_016_0122_9
crossref_primary_10_1371_journal_pone_0051528
crossref_primary_10_1016_j_toxicon_2013_08_054
crossref_primary_10_1098_rstb_2020_0163
crossref_primary_10_1093_gbe_evv257
crossref_primary_10_1016_j_margen_2011_09_002
crossref_primary_10_1074_mcp_M113_028647
crossref_primary_10_1371_journal_pone_0059534
crossref_primary_10_3390_md14110199
crossref_primary_10_1093_gigascience_giab037
crossref_primary_10_3390_ijms19123901
crossref_primary_10_1016_j_margen_2016_09_002
crossref_primary_10_1007_s00018_023_04935_0
crossref_primary_10_1371_journal_pbio_3002733
crossref_primary_10_3390_md16110417
crossref_primary_10_1016_j_jprot_2013_07_007
crossref_primary_10_3390_molecules29246061
crossref_primary_10_1016_j_jprot_2018_05_009
crossref_primary_10_3389_fmars_2022_1060432
crossref_primary_10_1016_j_jprot_2012_06_001
crossref_primary_10_1021_acs_jproteome_5b00630
crossref_primary_10_1074_mcp_M113_030353
crossref_primary_10_1021_pr500583u
crossref_primary_10_1016_S1995_7645_14_60342_4
crossref_primary_10_1016_j_jmb_2021_166957
crossref_primary_10_1016_j_toxicon_2014_10_003
crossref_primary_10_1186_1471_2164_14_708
crossref_primary_10_2174_0109298665279447231106072246
crossref_primary_10_1016_j_bbapap_2011_12_004
crossref_primary_10_1074_mcp_M112_021469
crossref_primary_10_1371_journal_pone_0082495
crossref_primary_10_1016_j_gene_2012_01_009
crossref_primary_10_3389_fbioe_2023_1166601
crossref_primary_10_3390_ijms19113418
crossref_primary_10_3390_toxins11110623
crossref_primary_10_1186_s40665_016_0019_y
crossref_primary_10_1016_j_toxicon_2018_02_005
crossref_primary_10_1093_gbe_evv109
crossref_primary_10_34133_2022_9895270
crossref_primary_10_1039_C2NP20085F
crossref_primary_10_1371_journal_pone_0156649
crossref_primary_10_3390_md20050291
crossref_primary_10_1016_j_bbapap_2012_12_015
crossref_primary_10_1073_pnas_1501334112
crossref_primary_10_3390_toxins7062159
crossref_primary_10_2174_1389203721666200426233758
crossref_primary_10_1016_j_toxicon_2017_04_003
crossref_primary_10_1021_acs_chemrev_9b00207
crossref_primary_10_4155_fmc_14_99
crossref_primary_10_4155_fmc_12_70
crossref_primary_10_52547_ismj_24_5_505
crossref_primary_10_1016_j_ttbdis_2015_03_013
crossref_primary_10_1371_journal_pone_0087648
crossref_primary_10_1093_gbe_evy150
crossref_primary_10_1016_j_toxicon_2012_04_340
crossref_primary_10_1016_j_toxicon_2012_06_011
crossref_primary_10_1186_gb_2013_14_9_406
crossref_primary_10_1093_molbev_msad171
crossref_primary_10_3390_md17100553
crossref_primary_10_1016_j_apsb_2021_03_001
crossref_primary_10_3390_biomedicines9040344
crossref_primary_10_1186_s12864_023_09689_4
crossref_primary_10_1016_j_toxicon_2013_04_022
crossref_primary_10_1007_s00227_018_3308_0
crossref_primary_10_1021_pr3006155
crossref_primary_10_1038_s41467_023_38924_5
crossref_primary_10_1111_j_1749_6632_2012_06603_x
crossref_primary_10_1021_pr1012976
crossref_primary_10_1186_1471_2164_13_271
crossref_primary_10_3390_md11062203
crossref_primary_10_3390_md15040103
crossref_primary_10_1007_s00239_012_9507_2
crossref_primary_10_3390_md20020105
crossref_primary_10_3390_toxins9120397
crossref_primary_10_1186_1471_2164_13_312
crossref_primary_10_1186_s12864_016_2755_6
crossref_primary_10_1186_1471_2164_15_1153
crossref_primary_10_1186_s12864_015_1830_8
crossref_primary_10_1021_cr400401e
crossref_primary_10_1093_abbs_gmv105
crossref_primary_10_3390_md17030193
crossref_primary_10_1007_s00438_015_1119_2
crossref_primary_10_2989_1814232X_2013_830990
crossref_primary_10_1074_mcp_M113_031351
crossref_primary_10_1093_bfgp_elz017
crossref_primary_10_1007_s10126_014_9595_7
crossref_primary_10_1021_jm401254c
crossref_primary_10_1093_gigascience_giad075
crossref_primary_10_1021_acs_jproteome_6b00776
crossref_primary_10_3390_md12126058
crossref_primary_10_1186_1471_2164_13_284
Cites_doi 10.1152/physrev.00020.2003
10.1038/75556
10.1038/381148a0
10.1016/j.toxicon.2006.04.013
10.1101/gr.079053.108
10.1091/mbc.8.11.2101
10.1345/aph.1G584
10.1007/s00239-010-9321-7
10.1016/j.cbpa.2003.12.004
10.1074/jbc.272.8.4689
10.1124/mi.7.5.7
10.1074/jbc.M702891200
10.1016/S0022-2836(05)80360-2
10.1074/jbc.R600037200
10.1021/bi962840p
10.1242/dev.00167
10.2144/000112900
10.1089/ars.2009.2466
10.1002/pro.5560020401
10.1159/000084979
10.1093/abbs/36.11.713
10.1093/bioinformatics/btm596
10.2174/138161208785777469
10.1101/gr.089532.108
10.1073/pnas.0837789100
10.1093/oxfordjournals.molbev.a026412
10.1093/bioinformatics/btm071
10.1046/j.1432-1033.2002.03335.x
10.1186/gb-2009-10-3-r25
10.1007/PL00000763
10.1073/pnas.2335845100
10.1101/gr.88502
10.1074/jbc.M205883200
10.1016/j.toxicon.2008.10.017
10.1186/1471-2105-4-41
10.1080/10409230591008161
10.1021/bi802259a
10.1016/j.bbamcr.2007.11.010
10.1016/j.ygeno.2006.06.014
10.1016/S0041-0101(01)00175-1
10.1073/pnas.022637099
10.1111/j.1742-4658.2007.06003.x
10.1074/jbc.274.43.30664
10.1038/nrd1197
10.1093/oxfordjournals.molbev.a003786
10.1074/jbc.M406281200
10.1074/jbc.R600020200
10.1074/jbc.271.45.28002
10.1021/cr050313i
10.2174/0929867043363884
10.1016/j.ympev.2004.09.012
10.1021/bi010683a
10.1016/j.toxicon.2008.05.004
10.1016/j.biochi.2005.08.001
10.1074/jbc.270.28.16719
10.1016/0300-9629(74)90008-5
10.1093/bioinformatics/btp352
10.1074/jbc.M309654200
10.1021/bi0489412
ContentType Journal Article
Copyright Hu et al; licensee BioMed Central Ltd. 2011 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
COPYRIGHT 2011 BioMed Central Ltd.
2011 Hu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright ©2011 Hu et al; licensee BioMed Central Ltd. 2011 Hu et al; licensee BioMed Central Ltd.
Copyright_xml – notice: Hu et al; licensee BioMed Central Ltd. 2011 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: COPYRIGHT 2011 BioMed Central Ltd.
– notice: 2011 Hu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright ©2011 Hu et al; licensee BioMed Central Ltd. 2011 Hu et al; licensee BioMed Central Ltd.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISR
3V.
7QP
7QR
7SS
7TK
7U7
7X7
7XB
88E
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOA
DOI 10.1186/1471-2164-12-60
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Science in Context
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Entomology Abstracts (Full archive)
Neurosciences Abstracts
Toxicology Abstracts
ProQuest Health & Medical Complete
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Proquest SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
Toxicology Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database

MEDLINE - Academic



MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen Free (Free internet resource, activated by CARLI)
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1471-2164
EndPage 60
ExternalDocumentID oai_doaj_org_article_4994886649a04a3688ede330b55b46f1
PMC3040727
2502039131
A249342008
21266071
10_1186_1471_2164_12_60
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GeographicLocations United States
GeographicLocations_xml – name: United States
GrantInformation_xml – fundername: NIGMS NIH HHS
  grantid: R01 GM099939
– fundername: NIGMS NIH HHS
  grantid: GM48677
– fundername: NHGRI NIH HHS
  grantid: 1R01HG004694
GroupedDBID ---
0R~
23N
2VQ
2WC
2XV
4.4
53G
5VS
6J9
7X7
88E
8AO
8FE
8FH
8FI
8FJ
AAFWJ
AAHBH
AAJSJ
AASML
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHSBF
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C1A
C6C
CCPQU
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EJD
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
H13
HCIFZ
HMCUK
HYE
IAO
IGS
IHR
INH
INR
IPNFZ
ISR
ITC
KQ8
LK8
M1P
M48
M7P
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RIG
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
U2A
UKHRP
W2D
WOQ
WOW
XSB
AAYXX
ALIPV
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7QP
7QR
7SS
7TK
7U7
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
7X8
5PM
ID FETCH-LOGICAL-c693t-b17359537b27a2cd80062db278df2317061f409efc035f82dd97c275e091f70a3
IEDL.DBID M48
ISSN 1471-2164
IngestDate Wed Aug 27 01:15:26 EDT 2025
Thu Aug 21 18:27:23 EDT 2025
Thu Sep 04 19:22:55 EDT 2025
Fri Jul 25 10:23:25 EDT 2025
Tue Jun 17 22:07:09 EDT 2025
Tue Jun 10 21:05:13 EDT 2025
Fri Jun 27 05:34:21 EDT 2025
Mon Jul 21 05:26:15 EDT 2025
Tue Jul 01 02:21:52 EDT 2025
Thu Apr 24 22:58:55 EDT 2025
Sat Sep 06 07:28:43 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Ziconotide
Transcriptome Assembly
Estimate Genome Size
Simple Repeat
Repeat Content
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c693t-b17359537b27a2cd80062db278df2317061f409efc035f82dd97c275e091f70a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1186/1471-2164-12-60
PMID 21266071
PQID 902038124
PQPubID 44682
ParticipantIDs doaj_primary_oai_doaj_org_article_4994886649a04a3688ede330b55b46f1
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3040727
proquest_miscellaneous_852909910
proquest_journals_902038124
gale_infotracmisc_A249342008
gale_infotracacademiconefile_A249342008
gale_incontextgauss_ISR_A249342008
pubmed_primary_21266071
crossref_citationtrail_10_1186_1471_2164_12_60
crossref_primary_10_1186_1471_2164_12_60
springer_journals_10_1186_1471_2164_12_60
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2011-01-25
PublicationDateYYYYMMDD 2011-01-25
PublicationDate_xml – month: 01
  year: 2011
  text: 2011-01-25
  day: 25
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle BMC genomics
PublicationTitleAbbrev BMC Genomics
PublicationTitleAlternate BMC Genomics
PublicationYear 2011
Publisher BioMed Central
BioMed Central Ltd
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: BMC
References H Tanaka (3197_CR57) 2003; 100
M Ashburner (3197_CR41) 2000; 25
R Hinegardner (3197_CR37) 1974; 47
W Zhi-Qiang (3197_CR62) 2007; 274
H Terlau (3197_CR14) 1996; 381
DJD Espiritu (3197_CR23) 2001; 39
SF Altschul (3197_CR35) 1990; 215
JT Simpson (3197_CR34) 2009; 19
EC Jimenez (3197_CR59) 1996; 281
P Bouchet (3197_CR3) 2005
R Apweiler (3197_CR40) 2004; 8
E van Anken (3197_CR46) 2005; 40
G Bulaj (3197_CR61) 2003; 100
GP Miljanich (3197_CR7) 2004; 11
RJ Lewis (3197_CR9) 2003; 2
B Langmead (3197_CR64) 2009; 10
M Holford (3197_CR17) 2009; 53
E Czerwiec (3197_CR49) 2002; 269
C Thorpe (3197_CR45) 2007; 282
BA Eipper (3197_CR51) 1993; 2
JS Biggs (3197_CR20) 2008; 52
Y Shikata (3197_CR60) 1995; 270
SG Conticello (3197_CR5) 2001; 18
TF Duda Jr (3197_CR21) 2000; 17
3197_CR1
SS Lynch (3197_CR6) 2006; 40
EC Jimenez (3197_CR55) 2004; 43
ST Prigge (3197_CR52) 2000; 57
CZ Wang (3197_CR11) 2004; 36
3197_CR31
AG Craig (3197_CR54) 1997; 272
3197_CR36
H Terlau (3197_CR4) 2004; 84
G Parra (3197_CR38) 2007; 23
RL Tatusov (3197_CR39) 2003; 4
BM Olivera (3197_CR10) 2007; 7
C Walker (3197_CR26) 1999; 274
TF Duda Jr (3197_CR22) 2005; 34
C Pi (3197_CR27) 2006; 88
Z Bao (3197_CR33) 2002; 12
BM Olivera (3197_CR15) 1997; 8
FH Vaillancourt (3197_CR58) 2006; 106
EC Jimenez (3197_CR53) 1997; 36
D Röckel (3197_CR13) 1995
PK Bandyopadhyay (3197_CR48) 2002; 99
MJ Chaisson (3197_CR63) 2009; 19
3197_CR30
C Appenzeller-Herzog (3197_CR43) 2007; 1783
R Fujii (3197_CR56) 2002; 277
AS Alvarado (3197_CR2) 2002; 129
AD Santos (3197_CR24) 2004; 279
TS Han (3197_CR8) 2008; 14
P Bandyopadhyay (3197_CR18) 2007
VD Twede (3197_CR25) 2009; 48
Q Kaas (3197_CR42) 2008; 24
G Bulaj (3197_CR67) 2001; 40
M De (3197_CR50) 2007; 282
HBG Safavi-Hemami (3197_CR47) 2010
RA Fisher (3197_CR66) 1938
N Puillandre (3197_CR68) 2010; 70
H Li (3197_CR65) 2009; 25
C Pi (3197_CR28) 2005; 88
L Azam (3197_CR16) 2005; 280
BM Olivera (3197_CR12) 2006; 281
PK Bandyopadhyay (3197_CR19) 2006; 48
F Hatahet (3197_CR44) 2009; 11
J Jurka (3197_CR32) 2005; 110
R Morin (3197_CR29) 2008; 45
20147296 - J Biol Chem. 2010 Apr 23;285(17):12735-46
2231712 - J Mol Biol. 1990 Oct 5;215(3):403-10
14573706 - Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2:14562-8
16895332 - Chem Rev. 2006 Aug;106(8):3364-78
14715910 - Physiol Rev. 2004 Jan;84(1):41-68
9362055 - Mol Biol Cell. 1997 Nov;8(11):2101-9
10521453 - J Biol Chem. 1999 Oct 22;274(43):30664-71
17562710 - J Biol Chem. 2007 Aug 10;282(32):23362-71
16905531 - J Biol Chem. 2006 Oct 20;281(42):31173-7
9030520 - J Biol Chem. 1997 Feb 21;272(8):4689-98
19309162 - Biochemistry. 2009 May 19;48(19):4063-73
18611170 - Biotechniques. 2008 Jul;45(1):81-94
10958845 - Mol Biol Evol. 2000 Sep;17(9):1286-93
15520009 - J Biol Chem. 2005 Jan 7;280(1):80-7
15578997 - Curr Med Chem. 2004 Dec;11(23):3029-40
16849624 - Ann Pharmacother. 2006 Jul-Aug;40(7-8):1293-300
14526382 - Nat Rev Drug Discov. 2003 Oct;2(10):790-802
18625510 - Toxicon. 2008 Jul;52(1):101-5
16093699 - Cytogenet Genome Res. 2005;110(1-4):462-7
15379573 - Biochemistry. 2004 Sep 28;43(38):12343-8
11683628 - Biochemistry. 2001 Nov 6;40(44):13201-8
17332020 - Bioinformatics. 2007 May 1;23(9):1061-7
15036160 - Curr Opin Chem Biol. 2004 Feb;8(1):76-80
10802651 - Nat Genet. 2000 May;25(1):25-9
19505943 - Bioinformatics. 2009 Aug 15;25(16):2078-9
18781995 - Curr Pharm Des. 2008;14(24):2462-79
19476414 - Antioxid Redox Signal. 2009 Nov;11(11):2807-50
17697113 - FEBS J. 2007 Sep;274(18):4778-87
12074021 - Nature. 1996 May 9;381(6578):148-51
4156206 - Comp Biochem Physiol A Comp Physiol. 1974 Feb 1;47(2):447-60
20143226 - J Mol Evol. 2010 Feb;70(2):190-202
16126486 - Crit Rev Biochem Mol Biol. 2005 Jul-Aug;40(4):191-228
17932414 - Mol Interv. 2007 Oct;7(5):251-60
11818531 - Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1264-9
18093543 - Biochim Biophys Acta. 2008 Apr;1783(4):535-48
11028916 - Cell Mol Life Sci. 2000 Aug;57(8-9):1236-59
12969510 - BMC Bioinformatics. 2003 Sep 11;4:41
11600154 - Toxicon. 2001 Dec;39(12):1899-916
18065428 - Bioinformatics. 2008 Feb 1;24(3):445-6
15619440 - Mol Phylogenet Evol. 2005 Feb;34(2):257-72
14701840 - J Biol Chem. 2004 Apr 23;279(17):17596-606
7622482 - J Biol Chem. 1995 Jul 14;270(28):16719-23
12719537 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6
19251739 - Genome Res. 2009 Jun;19(6):1117-23
12118011 - J Biol Chem. 2002 Sep 13;277(37):34010-6
12421706 - Development. 2002 Dec;129(24):5659-65
19261174 - Genome Biol. 2009;10(3):R25
11158371 - Mol Biol Evol. 2001 Feb;18(2):120-31
12473112 - Eur J Biochem. 2002 Dec;269(24):6162-72
16183187 - Biochimie. 2006 Feb;88(2):131-40
8910408 - J Biol Chem. 1996 Nov 8;271(45):28002-5
9033387 - Biochemistry. 1997 Feb 4;36(5):989-94
19056694 - Genome Res. 2009 Feb;19(2):336-46
16908117 - Genomics. 2006 Dec;88(6):809-19
16806344 - Toxicon. 2006 Jul;48(1):29-43
15514844 - Acta Biochim Biophys Sin (Shanghai). 2004 Nov;36(11):713-23
17353193 - J Biol Chem. 2007 May 11;282(19):13929-33
17936021 - Mol Phylogenet Evol. 2008 Jan;46(1):215-23
12176934 - Genome Res. 2002 Aug;12(8):1269-76
18950653 - Toxicon. 2009 Jan;53(1):90-8
8518727 - Protein Sci. 1993 Apr;2(4):489-97
References_xml – volume: 84
  start-page: 41
  year: 2004
  ident: 3197_CR4
  publication-title: Physiological Reviews
  doi: 10.1152/physrev.00020.2003
– ident: 3197_CR36
– volume: 25
  start-page: 25
  issue: 1
  year: 2000
  ident: 3197_CR41
  publication-title: Nat Genet
  doi: 10.1038/75556
– volume: 381
  start-page: 148
  issue: 6578
  year: 1996
  ident: 3197_CR14
  publication-title: Nature
  doi: 10.1038/381148a0
– volume: 48
  start-page: 29
  year: 2006
  ident: 3197_CR19
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2006.04.013
– volume: 19
  start-page: 336
  issue: 2
  year: 2009
  ident: 3197_CR63
  publication-title: Genome Res
  doi: 10.1101/gr.079053.108
– volume: 8
  start-page: 2101
  year: 1997
  ident: 3197_CR15
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.8.11.2101
– ident: 3197_CR1
– volume: 40
  start-page: 1293
  year: 2006
  ident: 3197_CR6
  publication-title: Ann Pharmacother
  doi: 10.1345/aph.1G584
– volume: 70
  start-page: 190
  year: 2010
  ident: 3197_CR68
  publication-title: J Mol Evol
  doi: 10.1007/s00239-010-9321-7
– volume: 8
  start-page: 76
  issue: 1
  year: 2004
  ident: 3197_CR40
  publication-title: Curr Opin Chem Biol
  doi: 10.1016/j.cbpa.2003.12.004
– volume: 272
  start-page: 4689
  year: 1997
  ident: 3197_CR54
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.8.4689
– volume: 7
  start-page: 251
  issue: 5
  year: 2007
  ident: 3197_CR10
  publication-title: Molecular Interventions
  doi: 10.1124/mi.7.5.7
– volume: 282
  start-page: 23362
  issue: 32
  year: 2007
  ident: 3197_CR50
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.M702891200
– volume: 215
  start-page: 403
  issue: 3
  year: 1990
  ident: 3197_CR35
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(05)80360-2
– volume: 282
  start-page: 13929
  issue: 19
  year: 2007
  ident: 3197_CR45
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.R600037200
– volume: 36
  start-page: 989
  year: 1997
  ident: 3197_CR53
  publication-title: Biochemistry
  doi: 10.1021/bi962840p
– volume: 129
  start-page: 5659
  issue: 24
  year: 2002
  ident: 3197_CR2
  publication-title: Development
  doi: 10.1242/dev.00167
– volume: 45
  start-page: 81
  issue: 1
  year: 2008
  ident: 3197_CR29
  publication-title: Biotechniques
  doi: 10.2144/000112900
– volume: 11
  start-page: 2807
  issue: 11
  year: 2009
  ident: 3197_CR44
  publication-title: Antioxidants & Redox Signaling
  doi: 10.1089/ars.2009.2466
– volume: 2
  start-page: 489
  year: 1993
  ident: 3197_CR51
  publication-title: Protein Sci
  doi: 10.1002/pro.5560020401
– volume: 110
  start-page: 462
  issue: 1-4
  year: 2005
  ident: 3197_CR32
  publication-title: Cytogenet Genome Res
  doi: 10.1159/000084979
– volume: 36
  start-page: 713
  issue: 11
  year: 2004
  ident: 3197_CR11
  publication-title: Acta Biochimica et Biophysica Sinica
  doi: 10.1093/abbs/36.11.713
– volume-title: Molecular Phylogenetics and Evolution
  year: 2007
  ident: 3197_CR18
– volume: 24
  start-page: 445
  issue: 3
  year: 2008
  ident: 3197_CR42
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btm596
– volume: 14
  start-page: 2462
  issue: 24
  year: 2008
  ident: 3197_CR8
  publication-title: Curr Pharm Des
  doi: 10.2174/138161208785777469
– volume: 19
  start-page: 1117
  issue: 6
  year: 2009
  ident: 3197_CR34
  publication-title: Genome Res
  doi: 10.1101/gr.089532.108
– volume: 100
  start-page: 6251
  year: 2003
  ident: 3197_CR57
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0837789100
– volume-title: Manual of the living Conidae
  year: 1995
  ident: 3197_CR13
– volume: 17
  start-page: 1286
  year: 2000
  ident: 3197_CR21
  publication-title: Mol Biol Evol
  doi: 10.1093/oxfordjournals.molbev.a026412
– volume: 23
  start-page: 1061
  issue: 9
  year: 2007
  ident: 3197_CR38
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btm071
– volume: 269
  start-page: 6162
  year: 2002
  ident: 3197_CR49
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03335.x
– volume: 10
  start-page: R25
  issue: 3
  year: 2009
  ident: 3197_CR64
  publication-title: Genome Biol
  doi: 10.1186/gb-2009-10-3-r25
– volume: 57
  start-page: 1236
  year: 2000
  ident: 3197_CR52
  publication-title: Cellular and Molecular Life Sciences
  doi: 10.1007/PL00000763
– volume: 100
  start-page: 14562
  issue: Supp 2
  year: 2003
  ident: 3197_CR61
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.2335845100
– volume: 12
  start-page: 1269
  issue: 8
  year: 2002
  ident: 3197_CR33
  publication-title: Genome Res
  doi: 10.1101/gr.88502
– volume-title: Statistical Tables
  year: 1938
  ident: 3197_CR66
– volume: 277
  start-page: 34010
  year: 2002
  ident: 3197_CR56
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M205883200
– volume: 53
  start-page: 90
  issue: 1
  year: 2009
  ident: 3197_CR17
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2008.10.017
– volume: 4
  start-page: 41
  year: 2003
  ident: 3197_CR39
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-4-41
– volume: 40
  start-page: 191
  year: 2005
  ident: 3197_CR46
  publication-title: Critical Reviews in Biochemistry and Molecular Biology
  doi: 10.1080/10409230591008161
– volume: 48
  start-page: 4063
  issue: 19
  year: 2009
  ident: 3197_CR25
  publication-title: Biochemistry
  doi: 10.1021/bi802259a
– volume: 1783
  start-page: 535
  year: 2007
  ident: 3197_CR43
  publication-title: Biochimica et Biophysica Acta
  doi: 10.1016/j.bbamcr.2007.11.010
– ident: 3197_CR30
– volume: 88
  start-page: 809
  issue: 6
  year: 2006
  ident: 3197_CR27
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2006.06.014
– volume: 39
  start-page: 1899
  year: 2001
  ident: 3197_CR23
  publication-title: Toxicon
  doi: 10.1016/S0041-0101(01)00175-1
– volume: 99
  start-page: 1264
  year: 2002
  ident: 3197_CR48
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.022637099
– volume: 274
  start-page: 4778
  year: 2007
  ident: 3197_CR62
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2007.06003.x
– volume: 274
  start-page: 30664
  year: 1999
  ident: 3197_CR26
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.43.30664
– volume: 2
  start-page: 790
  issue: 10
  year: 2003
  ident: 3197_CR9
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd1197
– volume: 18
  start-page: 120
  issue: 2
  year: 2001
  ident: 3197_CR5
  publication-title: Mol Biol Evol
  doi: 10.1093/oxfordjournals.molbev.a003786
– volume: 280
  start-page: 80
  issue: 1
  year: 2005
  ident: 3197_CR16
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M406281200
– volume: 281
  start-page: 31173
  issue: 42
  year: 2006
  ident: 3197_CR12
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.R600020200
– ident: 3197_CR31
– volume: 281
  start-page: 28002
  year: 1996
  ident: 3197_CR59
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.45.28002
– volume: 106
  start-page: 3364
  year: 2006
  ident: 3197_CR58
  publication-title: Chem Rev
  doi: 10.1021/cr050313i
– volume: 11
  start-page: 3029
  year: 2004
  ident: 3197_CR7
  publication-title: Current Medicinal Chemistry
  doi: 10.2174/0929867043363884
– volume: 34
  start-page: 257
  issue: 2
  year: 2005
  ident: 3197_CR22
  publication-title: Mol Phylogenet Evol
  doi: 10.1016/j.ympev.2004.09.012
– volume: 40
  start-page: 13201
  year: 2001
  ident: 3197_CR67
  publication-title: Biochemistry
  doi: 10.1021/bi010683a
– volume: 52
  start-page: 101
  issue: 1
  year: 2008
  ident: 3197_CR20
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2008.05.004
– volume: 88
  start-page: 131
  issue: 2
  year: 2005
  ident: 3197_CR28
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2005.08.001
– volume: 270
  start-page: 16719
  year: 1995
  ident: 3197_CR60
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.28.16719
– volume: 47
  start-page: 447
  issue: 2
  year: 1974
  ident: 3197_CR37
  publication-title: Comp Biochem Physiol A Comp Physiol
  doi: 10.1016/0300-9629(74)90008-5
– volume-title: Malacologia: International Journal of Malacology, Classification and Nomenclator of Gastropod Families
  year: 2005
  ident: 3197_CR3
– volume: 25
  start-page: 2078
  issue: 16
  year: 2009
  ident: 3197_CR65
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
– volume: 279
  start-page: 17596
  year: 2004
  ident: 3197_CR24
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.M309654200
– volume-title: J Biol Chem
  year: 2010
  ident: 3197_CR47
– volume: 43
  start-page: 12343
  year: 2004
  ident: 3197_CR55
  publication-title: Biochemistry
  doi: 10.1021/bi0489412
– reference: 9030520 - J Biol Chem. 1997 Feb 21;272(8):4689-98
– reference: 19251739 - Genome Res. 2009 Jun;19(6):1117-23
– reference: 14526382 - Nat Rev Drug Discov. 2003 Oct;2(10):790-802
– reference: 14701840 - J Biol Chem. 2004 Apr 23;279(17):17596-606
– reference: 16895332 - Chem Rev. 2006 Aug;106(8):3364-78
– reference: 16183187 - Biochimie. 2006 Feb;88(2):131-40
– reference: 15514844 - Acta Biochim Biophys Sin (Shanghai). 2004 Nov;36(11):713-23
– reference: 8910408 - J Biol Chem. 1996 Nov 8;271(45):28002-5
– reference: 8518727 - Protein Sci. 1993 Apr;2(4):489-97
– reference: 18781995 - Curr Pharm Des. 2008;14(24):2462-79
– reference: 15619440 - Mol Phylogenet Evol. 2005 Feb;34(2):257-72
– reference: 20143226 - J Mol Evol. 2010 Feb;70(2):190-202
– reference: 15520009 - J Biol Chem. 2005 Jan 7;280(1):80-7
– reference: 12118011 - J Biol Chem. 2002 Sep 13;277(37):34010-6
– reference: 16126486 - Crit Rev Biochem Mol Biol. 2005 Jul-Aug;40(4):191-228
– reference: 11818531 - Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1264-9
– reference: 19476414 - Antioxid Redox Signal. 2009 Nov;11(11):2807-50
– reference: 10802651 - Nat Genet. 2000 May;25(1):25-9
– reference: 19056694 - Genome Res. 2009 Feb;19(2):336-46
– reference: 16849624 - Ann Pharmacother. 2006 Jul-Aug;40(7-8):1293-300
– reference: 11600154 - Toxicon. 2001 Dec;39(12):1899-916
– reference: 12176934 - Genome Res. 2002 Aug;12(8):1269-76
– reference: 19261174 - Genome Biol. 2009;10(3):R25
– reference: 12421706 - Development. 2002 Dec;129(24):5659-65
– reference: 9362055 - Mol Biol Cell. 1997 Nov;8(11):2101-9
– reference: 17353193 - J Biol Chem. 2007 May 11;282(19):13929-33
– reference: 11028916 - Cell Mol Life Sci. 2000 Aug;57(8-9):1236-59
– reference: 12074021 - Nature. 1996 May 9;381(6578):148-51
– reference: 11683628 - Biochemistry. 2001 Nov 6;40(44):13201-8
– reference: 14573706 - Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2:14562-8
– reference: 17936021 - Mol Phylogenet Evol. 2008 Jan;46(1):215-23
– reference: 12969510 - BMC Bioinformatics. 2003 Sep 11;4:41
– reference: 14715910 - Physiol Rev. 2004 Jan;84(1):41-68
– reference: 9033387 - Biochemistry. 1997 Feb 4;36(5):989-94
– reference: 19505943 - Bioinformatics. 2009 Aug 15;25(16):2078-9
– reference: 10958845 - Mol Biol Evol. 2000 Sep;17(9):1286-93
– reference: 18950653 - Toxicon. 2009 Jan;53(1):90-8
– reference: 16905531 - J Biol Chem. 2006 Oct 20;281(42):31173-7
– reference: 7622482 - J Biol Chem. 1995 Jul 14;270(28):16719-23
– reference: 17932414 - Mol Interv. 2007 Oct;7(5):251-60
– reference: 11158371 - Mol Biol Evol. 2001 Feb;18(2):120-31
– reference: 18093543 - Biochim Biophys Acta. 2008 Apr;1783(4):535-48
– reference: 15036160 - Curr Opin Chem Biol. 2004 Feb;8(1):76-80
– reference: 17562710 - J Biol Chem. 2007 Aug 10;282(32):23362-71
– reference: 18625510 - Toxicon. 2008 Jul;52(1):101-5
– reference: 2231712 - J Mol Biol. 1990 Oct 5;215(3):403-10
– reference: 16806344 - Toxicon. 2006 Jul;48(1):29-43
– reference: 15578997 - Curr Med Chem. 2004 Dec;11(23):3029-40
– reference: 16093699 - Cytogenet Genome Res. 2005;110(1-4):462-7
– reference: 18065428 - Bioinformatics. 2008 Feb 1;24(3):445-6
– reference: 18611170 - Biotechniques. 2008 Jul;45(1):81-94
– reference: 15379573 - Biochemistry. 2004 Sep 28;43(38):12343-8
– reference: 20147296 - J Biol Chem. 2010 Apr 23;285(17):12735-46
– reference: 17332020 - Bioinformatics. 2007 May 1;23(9):1061-7
– reference: 10521453 - J Biol Chem. 1999 Oct 22;274(43):30664-71
– reference: 16908117 - Genomics. 2006 Dec;88(6):809-19
– reference: 17697113 - FEBS J. 2007 Sep;274(18):4778-87
– reference: 12473112 - Eur J Biochem. 2002 Dec;269(24):6162-72
– reference: 4156206 - Comp Biochem Physiol A Comp Physiol. 1974 Feb 1;47(2):447-60
– reference: 19309162 - Biochemistry. 2009 May 19;48(19):4063-73
– reference: 12719537 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6
SSID ssj0017825
Score 2.3502712
Snippet Background The venomous marine gastropods, cone snails (genus Conus ), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each...
The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high...
Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each...
Abstract Background: The venomous marine gastropods, cone snails (genus Conus ), inject prey with a lethal cocktail of conopeptides, small cysteine-rich...
Abstract Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 60
SubjectTerms Amino acids
Animal Genetics and Genomics
Animals
Base Composition - genetics
Biomedical and Life Sciences
Cone snails
Conus Snail - genetics
Gene Expression Profiling
Genetic aspects
Genome - genetics
Genomes
Genomics
Life Sciences
Microarrays
Microbial Genetics and Genomics
Molecular Sequence Annotation
Mollusk Venoms - genetics
Multicellular invertebrate genomics
Peptides
Peptides - genetics
Pharmacology
Physiological aspects
Plant Genetics and Genomics
Proteomics
Reagents
Research Article
RNA
Single nucleotide polymorphisms
Software
Studies
Venom
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1da9YwFA4yELwRnV91HwQR1Iu6tEmT9nK-bEzBXaiD3YU0HzqYrdi-gv_ec9K83ToZ3njXJqfQnJ7kPKc55wkhLxk3wRdlyAFbi1y03OXG1iZ3LRZmNtw2MRnz46k8ORMfzqvza0d9YU7YRA88Ke4AEDnYmJSiMUwYLuvaOw9BeFtVrZAhBj6sYZtgKu0fgN-rYl2RKvISIoJE6lPU8mBuw6SEyEx55Y8ibf_fi_M173Qzc_LG9mn0SscPyP0EJ-nhNIyH5I7vtsnd6YDJ34_I6WrmY57KLWkfKEA-uuq79UBbiD_NCBfI1PrdU9M5ejEO9Bfe5sgES0f0ZXFlAYHH5Oz46MvqJE8nKORWNnzM20Jh4S1XbalMaV2NJZMObmoXANgpcOYBAjwfLONVqEvnGmVLVXlAEUExw5-Qra7v_DNC29IpKQrGoF1YG4zhSkhTYcjEueIZebvRo7aJXhxPubjUMcyopUbFa1S8LkotWUZezw_8mJg1bhd9hx9mFkNK7NgAhqKToeh_GUpGXuBn1Uh60WFWzVezHgb9_vMnfQgxKBeYCZKRV0ko9PD21qQiBdAB8mQtJHcXkjAr7aJ7Z2M9Oq0Kg25w2xcRVUbo3IsPYqJb5_v1oOuqbAC0FzDmp5OpzaMGkCGRDTAjamGEC7Use7qLb5ExnDPkwVMZebMx16uXukXnz_-HznfIvekfPMy4apdsjT_Xfg9A3Njux_n6BwLlO0o
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3ta9YwEA9zQ_DL8N26KUEE9UNc27RJ-0Fke9iYwh5kOti3kOZlDrTd1j6C_713bdrZyfzWNldIrpd7ae5-R8jrmGvvktQz8K0zllXcMm0KzWyFhZklN2WfjHm0FIcn2efT_HSNHI21MJhWOerEXlHbxuA_8p0Sj8zQGn28uGTYNAoPV8cOGjp0VrAfeoSxO2QDNHIBYr-xt7_8cjwdK4A5zAO-T1KInQQ0M0shYMD8hB6k8to09Qj-_-rpvwzVzSTKGyepvYE6uE82g2dJdwdReEDWXP2Q3B16Tf5-RJaLCZp5qLykjafg_dFFU69aWkEoqju4QNDWn47q2tLzrqW_8JYhKCzt0Kz1SgYIHpOTg_1vi0MWmikwI0resSqRWIPLZZVKnRpbYPWkhZvCevDxJNh1D7Ge8ybmuS9Sa0tpUpk7cCi8jDV_QtbrpnbPCK1SK0WWxDE8z4zxWnOZCZ1j9MS55BF5P_JRmYA0jg0vfqg-4iiEQsYrZLxKUiXiiLydXrgYQDZuJ93DDzORITp2_6C5OlNhsymYB-glIbJSx5nmoiicdZzHVZ5XmfBJRF7hZ1WIf1Fjgs2ZXrWt-vT1WO1COMozTAqJyJtA5BuYvdGhXgF4gJBZM8rtGSVsUDMb3hqlRwUF0apJnCNCp1F8EXPeatesWlXkaQn-ewJrfjqI2rRqkG6BwIARkTMhnLFlPlKff-_Bw3mMkHgyIu9Gcb2e1C08f_7fBWyRe8N_dthK-TZZ765W7gU4al31Mmy_P3vKOE0
  priority: 102
  providerName: ProQuest
– databaseName: SpringerLink Journals (ICM)
  dbid: U2A
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Ni9UwEA_LiuBF_LbuKkEE9VBt89kenw-XVXAP6oO9hTQf64K2su0T_O-dSfuqXd2Dt7aZQDLJfDUzvxDyrOA2hpLFHHxrkYuG-9y6yua-wcLMmrs6JWN-OFHHG_H-VJ7ukXJXC5Oy3XdHkklTJ7Gu1OsS1GjOwLvHZAIFUfo1CYE7yuKGreaDAzB4ckLw-UenhfFJGP1_a-I_TNHlNMlLZ6XJBB3dIjcn35GuxsW-TfZCe4dcH2-T_HmXnKxn8OWxtpJ2kYJ_R9ddu-1pA8GmHeABYVm_BWpbT8-Hnv7A1xxhX-mAhiupESC4RzZHbz-vj_PpuoTcqZoPeVNqrLLlumHaMucrrI_08FL5CF6cBssdIZoL0RVcxop5X2vHtAzgMkRdWH6f7LddGx4S2jCvlSiLAr4L56K1XAtlJcZHnGuekVc7Pho3YYnjlRZfTYopKmWQ8QYZb0pmVJGRF3OH7yOMxtWkb3BhZjLEv04fuoszM4mTgXGA5lFK1LYQlquqCj5wXjRSNkLFMiNPcVkNIly0mEJzZrd9b959-mhWEHBygWkfGXk-EcUORu_sVJEAPEBQrAXl4YISRNAtmg92u8dMKqA3NZ7xovuUETq3YkfMamtDt-1NJVkNHnoJc34wbrV51uBRKIT-y4hebMIFW5Yt7fmXBA_OCwS90xl5uduuvwd1Bc8f_QftAbkx_lcHwZKHZH-42IbH4JgNzZMkir8AX04taw
  priority: 102
  providerName: Springer Nature
Title Characterization of the Conus bullatus genome and its venom-duct transcriptome
URI https://link.springer.com/article/10.1186/1471-2164-12-60
https://www.ncbi.nlm.nih.gov/pubmed/21266071
https://www.proquest.com/docview/902038124
https://www.proquest.com/docview/852909910
https://pubmed.ncbi.nlm.nih.gov/PMC3040727
https://doaj.org/article/4994886649a04a3688ede330b55b46f1
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9QwDI9gExIviG_KxilCSMBDR9ukSfuA0K3aNJB2QoOT7i1K02ZMGu127SH232OnvR4dm3ipmsatUteO7cb-hZA3AdO2DCPrg2_NfZ6zwtcm0X6RY2FmykzqkjGPZ-Jozr8s4sVmO6Cegc2NoR3uJzVfnu_9vrz6BAr_0Sl8Ij6EMMH6Efj9mGYgIH7fBrMkMBI75pslBTCFsSs16ol7nJ8bHjAyUQ7J_9_5-i-DdT2Z8tqKqjNUhw_Jg97DpNNOJB6RO2X1mNzr9py8ekJm2QDR3FVg0tpS8AJpVlerhuYQkuoWThC89WdJdVXQs7ahv7DpIzgsbdG8uckGCJ6S-eHB9-zI7zdV8I1IWevnocRaXCbzSOrIFAlWURbQSAoLvp4E-24h5iutCVhsk6goUmkiGZfgWFgZaPaMbFV1Vb4gNI8KKXgYBHCdG2O1ZpILHWMUxZhkHtlb81GZHnEcN744Vy7ySIRCxitkvAojJQKPvBtuuOjANm4n3ccPM5AhSra7UC9PVa90CsYB85MQPNUB10wkSVmUjAV5HOdc2NAjr_GzKsTBqDDR5lSvmkZ9_naiphCWMo7JIR552xPZGkZvdF-3ADxA6KwR5e6IEhTVjLp31tKj1nKuUlwJRifLI3ToxRsx960q61WjkjhKwY8P4Z2fd6I2vDX4HQIBAj0iR0I4Ysu4pzr74UDEWYDQeNIj79fiuhnULTx_-f8h7pD73U930Kd4l2y1y1X5Cry2Np-Qu3IhJ2R7_2D29QRamcgm7g_IxOkpHOfR9A_f5T1z
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NT9VAEJ_gI0Yvxm8rqBujUQ-Vttvutgdi4AnhCbwYhITbst1tkURbpH0a_jj_N2favmIxeOPWdqfN7uzufHRnfgPwyuM6z_wgd9G2Dt0w5dbVJtauTSkxM-EmaYIxd6di6yD8dBgdLsDveS4MhVXOZWIjqG1p6B_5SkJHZqSNPpz-cKloFB2uzito6K6ygl1tEMa6vI7t7PwXenDV6uQjTvfrINjc2B9vuV2RAdeIhNdu6kvKTeUyDaQOjI0pq9DiTWxztH0k6rscfaAsNx6P8jiwNpEmkFGGijaXnub43RuwGNJHRrC4vjH9vNcfY6D6jTo8IT8WKz5qAjdAB4XiIRpQzAtV2FQM-Fcv_KUYLwdtXjq5bRTi5l2401mybK1devdgISvuw822tuX5A5iOeyjoNtOTlTlDa5ONy2JWsRRdX13jBYHEfs-YLiw7qSv2k25dAqFlNanRRqghwUM4uBa-PoJRURbZE2BpYKUIfc_D56ExudZchkJH5K1xLrkD7-d8VKZDNqcCG99U4-HEQhHjFTFe-YESngNv-xdOW1CPq0nXaWJ6MkLjbh6UZ8eq29wK-4FyUIgw0V6ouYjjzGace2kUpaHIfQde0rQqwtsoKKDnWM-qSk2-7Kk1dH95SEEoDrzpiPISe290lx-BPCCIrgHl8oASBYIZNC_NV4_qBFKl-u3jAOtb6UWKsSuyclapOAoS9Bd8HPPjdqn1o0b7RhAQoQNysAgHbBm2FCdfG7By7hEEn3Tg3Xy5XnTqCp4__e8AXsCtrf3dHbUzmW4vwe32Hz9uq2gZRvXZLHuGRmKdPu-2IoOj6979fwChQXOI
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZQEYgL4k1oAQshAYfQxHbs5LgsrFoeKwSs1Jvl-FEqQVI1WST-PTN5QQo9cNvEY8kZz3M985mQpwk3wacsxBBbi1iU3MXG5iZ2JTZmFtwWXTHmh7U82Ii3R9nRUJvTjNXu45Fk39OAKE1Vu3_qQq_iudxPwaTGDCJ9LCyQkLFfBlucophv2GI6RADnlw1oPv-YNHNEHV7_31b5D7d0vmTy3Llp545WN8j1IY6ki37jb5JLvrpFrvQ3S_68TdbLCYi577OkdaAQ69FlXW0bWkLiaVr4gRCt3z01laMnbUN_4GOMELC0RSfWmRQguEM2qzdflgfxcHVCbGXB27hMFXbcclUyZZh1OfZKOnjIXYCIToEXD5DZ-WATnoWcOVcoy1TmIXwIKjH8Ltmp6srfJ7RkTkmRJgm8F9YGY7gS0mSYK3GueERejnzUdsAVx-stvukuv8ilRsZrZLxOmZZJRJ5PE057SI2LSV_hxkxkiIXdvajPjvWgWhrWAVZISlGYRBgu89w7z3lSZlkpZEgj8gS3VSPaRYXlNMdm2zT68PMnvYDkkwssAYnIs4Eo1LB6a4buBOABAmTNKPdmlKCOdja8O0qPHsxBows878VQKiJ0GsWJWOFW-Xrb6DxjBUTrKXzzvV7Upq-G6EIiDGBE1EwIZ2yZj1QnXzuocJ4gAJ6KyItRXH8v6gKeP_gP2sfk6sfXK_3-cP1ul1zr_24HHcv2yE57tvUPIV5ry0edVv4C3ro0mg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Characterization+of+the+Conus+bullatus+genome+and+its+venom-duct+transcriptome&rft.jtitle=BMC+genomics&rft.au=Hu%2C+Hao&rft.au=Bandyopadhyay%2C+Pradip+K&rft.au=Olivera%2C+Baldomero+M&rft.au=Yandell%2C+Mark&rft.date=2011-01-25&rft.issn=1471-2164&rft.eissn=1471-2164&rft.volume=12&rft.spage=60&rft_id=info:doi/10.1186%2F1471-2164-12-60&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2164&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2164&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2164&client=summon