Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study - Meneses, María E.; Martínez-Carrera, Daniel; González-Ibáñez, Laura; Torres, Nimbe; Sánchez-Tapia, Mónica; Márquez-Mota, Claudia C.; Rendón, Gilmar; Mitzi, Vladimir; Morales, Alfredo; Tello-Salgado, Isaac; Tovar, Armando R. (PloS one, 2023)
Keywords: Acetylsalicylic acid; Albumin; Albumins; Animals; Anticancer properties; Antioxidants; Aspirin; Biological products; Biology and Life Sciences; Biomarkers; Biomarkers - metabolism; Body weight; C-reactive protein; Care and treatment; Cholesterol; Clinical trials; Creatinine; Creatinine - metabolism; Dietary fiber; Dietary minerals; Drug dosages; Female; Females; Fungiculture; Ganoderma lucidum; Gastrointestinal Diseases - pathology; Gastrointestinal Microbiome; Gene expression; Genetic aspects; Genotypes; Glucose; Glucose - metabolism; Gut microbiota; Health aspects; Histopathology; Humidity; Inflammation; Injuries; Interleukin 6; Intestinal microflora; Kidney - pathology; Kidneys; Lipid metabolism; Liver; Liver - metabolism; Low density lipoproteins; Male; Males; Medicine and Health Sciences; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Mushrooms; Organ weight; Parameters; Physical Sciences; Physiological aspects; Plant Extracts - toxicity; Plastics; Polyphenols; Potassium; Prebiotics; Product development; Proteins; Rats; Rats, Wistar; Reishi; Reishi - chemistry; Research and Analysis Methods; Sawdust; Substrates; Testing; Therapeutic applications; TLR4 protein; Toll-like receptors; Toxicity; Toxicity testing; Tumor necrosis factor-α; Urea; Urea - metabolism; Ureas; Mexico; United States--US