Temporal dynamics of cerebral blood flow during the first year after moderate-severe traumatic brain injury: A longitudinal perfusion MRI study

• Published in: NeuroImage clinical Vol. 37; p. 103344
• Main Authors: Gaggi, Naomi L., Ware, Jeffrey B., Dolui, Sudipto, Brennan, Daniel, Torrellas, Julia, Wang, Ze, Whyte, John, Diaz-Arrastia, Ramon, Kim, Junghoon J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2023; Elsevier
• Subjects: Arterial spin labeling; Brain - blood supply; Brain Injuries, Traumatic - diagnostic imaging; Brain Injury, Chronic; Cerebral blood flow; Cerebrovascular Circulation - physiology; Cognitive function; Humans; Longitudinal; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Perfusion; Radiology; Regular; Spin Labels; Traumatic brain injury; msTBI; EF; PS; Traumatic brain injury; Longitudinal; MRI; CBF; GM; ASL MRI; DisCo-Z; Magnetic resonance imaging; FWE; Cerebral blood flow; VL; Arterial spin labeling; TBI; Cognitive function; magnetic resonance imaging; arterial spin labeled magnetic resonance imaging; traumatic brain injury; moderate-severe traumatic brain injury; family wise error; verbal learning; gray matter; cerebral blood flow; distribution corrected z-score; executive function; processing speed

•During the first year post-injury, cerebral blood flow (CBF) was decreased in TBI.•CBF worsened overall from 3 to 6 months post-injury in multiple regions.•From 6 to 12 months post-injury, CBF of the right precuneus increased in TBI.•CBF changes in TBI were not explained by concurrent cortical atro...