Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls

• Published in: PloS one Vol. 18; no. 3; p. e0282821
• Main Authors: Donovan, Margaret K. R., Huang, Yingxiang, Blume, John E., Wang, Jian, Hornburg, Daniel, Ferdosi, Shadi, Mohtashemi, Iman, Kim, Sangtae, Ko, Marwin, Benz, Ryan W., Platt, Theodore L., Batzoglou, Serafim, Diaz, Luis A., Farokhzad, Omid C., Siddiqui, Asim
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.03.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Biomarkers; Biomarkers, Tumor - metabolism; Blood plasma; Bone Morphogenetic Protein 1; Carcinoma, Non-Small-Cell Lung - metabolism; Complications and side effects; Diagnosis; Humans; Isoforms; Lung cancer; Lung cancer, Non-small cell; Lung diseases; Lung Neoplasms - metabolism; Medicine and Health Sciences; Non-small cell lung carcinoma; Peptides; Plasma; Protein Isoforms - metabolism; Proteins; Proteomes; Proteomics; Research and Analysis Methods; Small cell lung carcinoma; United States

Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers previously concealed by aggregated protein methods. Here, we analyze 188 plasma proteomes from non-small cell lung cancer subjects (NSCLC) and con...