Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women

• Published in: PloS one Vol. 18; no. 3; p. e0283831
• Main Authors: Sulastri, Delmi, Arnadi, Arnadi, Afriwardi, Afriwardi, Desmawati, Desmawati, Amir, Arni, Irawati, Nuzulia, Yanis, Amel, Yusrawati, Yusrawati
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.03.2023; Public Library of Science (PLoS)
• Subjects: Age; Analysis; Arthritis; Biology and Life Sciences; Body fat; Cartilage; Cartilage diseases; Chi-square test; Cross-Sectional Studies; Cytokines; Demographic aspects; Deoxyribonucleic acid; Diagnosis; DNA; Enzyme-linked immunosorbent assay; Enzymes; Extracellular matrix; Female; Gene Expression; Gene polymorphism; Genetic aspects; Genetic factors; Health aspects; Health risks; Hospitals; Humans; IL-1β; Informed consent; Interleukin; Interleukin 1; Knee; Matrix metalloproteinase; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 3 - metabolism; Matrix metalloproteinases; Medicine and Health Sciences; Menopause; Metalloproteinase; Nutrition; Nutritional status; Obesity; Older people; Orthopedics; Osteoarthritis; Osteoarthritis, Knee - genetics; Osteoarthritis, Knee - metabolism; Overweight; Pathogenesis; Pathophysiology; Polymorphism; Proteases; Risk analysis; Risk Factors; Statistical analysis; Stromelysin 1; Synovial fluid; Synovial Fluid - metabolism; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Women; Womens health; Indonesia

Metalloproteinases-3 (MMP3) are the main enzymes involved in cartilage degradation. Several genetic and non-genetic factors can increase the expression of MMP3 in patients with osteoarthritis (OA). This study aims to analyze the risk factors associated with the expression of the MMP3 gene rs679620 f...