Genetic Structures of Copy Number Variants Revealed by Genotyping Single Sperm

• Published in: PloS one Vol. 4; no. 4; p. e5236
• Main Authors: Luo, Minjie, Cui, Xiangfeng, Fredman, David, Brookes, Anthony J., Azaro, Marco A., Greenawalt, Danielle M., Hu, Guohong, Wang, Hui-Yun, Tereshchenko, Irina V., Lin, Yong, Shentu, Yue, Gao, Richeng, Shen, Li, Li, Honghua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.04.2009; Public Library of Science (PLoS)
• Subjects: Algorithms; Analysis; Biological evolution; Biotechnology; Cancer; Copy number; Dentistry; Deoxyribonucleic acid; Diploidy; DNA; DNA microarrays; Electrophoresis, Polyacrylamide Gel; Evolution; Evolutionary Biology; Evolutionary Biology/Genomics; Evolutionary Biology/Human Evolution; Gene Dosage; Gene expression; Genes; Genetic Markers; Genetic structure; Genetics; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Genomics; Genetics and Genomics/Population Genetics; Genomes; Genomics; Genotype; Genotyping; Haplotypes; Humans; Immunology; Male; Medical schools; Medicine; Meiosis; Multiplexing; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Recombination; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Sperm; Spermatozoa - metabolism; United States > US; China; New Jersey

Copy number variants (CNVs) occupy a significant portion of the human genome and may have important roles in meiotic recombination, human genome evolution and gene expression. Many genetic diseases may be underlain by CNVs. However, because of the presence of their multiple copies, variability in co...