Partial correlation analysis reveals abnormal retinotopically organized functional connectivity of visual areas in amblyopia

• Published in: NeuroImage clinical Vol. 18; pp. 192 - 201
• Main Authors: Mendola, J.D., Lam, J., Rosenstein, M., Lewis, L.B., Shmuel, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2018; Elsevier
• Subjects: Adult; Amblyopia - diagnostic imaging; Amblyopia - pathology; Binocular vision; Brain Mapping; Correlation of Data; Female; Fourier Analysis; Functional MRI; Humans; Image Processing, Computer-Assisted; Intrinsic; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen - blood; Partial correlation; Radiology; Regional; Regular; Rest; Resting state functional connectivity; Resting state functional magnetic resonance imaging; Retina - diagnostic imaging; Retina - physiopathology; Spontaneous activity; Strabismus; Suppression; Visual Cortex - diagnostic imaging; Visual Cortex - physiopathology; Visual Pathways - diagnostic imaging; Visual Pathways - physiopathology; Young Adult; Resting state functional magnetic resonance imaging; Strabismus; Suppression; rs-fMRI; Pcorr; Regional; Corr; Resting state functional connectivity; LGN; Functional MRI; Binocular vision; Spontaneous activity; Intrinsic; Partial correlation; partial correlation; lateral geniculate nucleus; resting state functional magnetic resonance imaging; correlation; Pcorr, partial correlation; rs-fMRI, resting state functional magnetic resonance imaging; LGN, lateral geniculate nucleus; Corr, correlation

Amblyopia is a prevalent developmental visual disorder of childhood that typically persists in adults. Due to altered visual experience during critical periods of youth, the structure and function of adult visual cortex is abnormal. In addition to substantial deficits shown with task-based fMRI, pre...