Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA

• Published in: Virology journal Vol. 14; no. 1; p. 138
• Main Authors: Meng, Bo, Bentley, Kirsten, Marriott, Anthony C., Scott, Paul D., Dimmock, Nigel J., Easton, Andrew J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.07.2017; BioMed Central; BMC
• Subjects: Antiviral agents; Cloning; Codons; Competitive advantage; Defective interfering RNA; Defective Viruses - genetics; Defective Viruses - immunology; Defective Viruses - isolation & purification; Dosage and administration; Genomes; Health aspects; HEK293 Cells; Humans; Influenza; Influenza A; Influenza A virus; Influenza A virus - genetics; Influenza A virus - growth & development; Influenza virus; Interference; Interferon; Interferon Type I - metabolism; interferons; mechanism of action; Mutation; Pandemics; progeny; Proteins; Replication; RNA; RNA Interference; RNA viruses; RNA, Viral - genetics; RNA, Viral - metabolism; RNA-mediated interference; Vaccines; virion; Virions; Viruses; Replication; Defective interfering RNA; Influenza virus; Interference

Defective interfering (DI) viruses are natural antivirals made by nearly all viruses. They have a highly deleted genome (thus being non-infectious) and interfere with the replication of genetically related infectious viruses. We have produced the first potential therapeutic DI virus for the clinic b...