Zeaxanthin dipalmitate-enriched wolfberry extract improves vision in a mouse model of photoreceptor degeneration

• Published in: PloS one Vol. 19; no. 5; p. e0302742
• Main Authors: Chen, Xiongmin, Zhang, Sensen, Yang, Lili, Kong, Qihang, Zhang, Wenhua, Zhang, Jinhong, Hao, Xiangfeng, So, Kwok-Fai, Xu, Ying
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.05.2024; Public Library of Science (PLoS)
• Subjects: Acuity; Animals; Apoptosis; Biology and Life Sciences; Carotenoids; Degeneration; Disease Models, Animal; Dried fruit; Electroretinography; Enrichment; Ethanol; Fruits; Gene therapy; Goji berries; Health aspects; High performance liquid chromatography; Laboratory animals; Light effects; Liquid chromatography; Lycium; Lycium - chemistry; Male; Medical research; Medicine and Health Sciences; Medicine, Experimental; Mice; Mice, Inbred C57BL; N-Methyl-N-nitrosourea; Photoreception; Photoreceptor Cells, Vertebrate - drug effects; Photoreceptor Cells, Vertebrate - pathology; Photoreceptors; Physical Sciences; Physiological aspects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Production lines; Prostheses; Research and Analysis Methods; Retina; Retina - drug effects; Retina - metabolism; Retina - pathology; Retinal degeneration; Retinal Degeneration - drug therapy; Retinal Degeneration - pathology; Social Sciences; Solvents; Vision; Vision, Ocular - drug effects; Visual acuity; Xanthophylls - pharmacology; Zeaxanthin; Zeaxanthins - pharmacology; China

Zeaxanthin dipalmitate (ZD) is a chemical extracted from wolfberry that protects degenerated photoreceptors in mouse retina. However, the pure ZD is expensive and hard to produce. In this study, we developed a method to enrich ZD from wolfberry on a production line and examined whether it may also p...