Elucidating the roles of SOD3 correlated genes and reactive oxygen species in rare human diseases using a bioinformatic-ontology approach

• Published in: PloS one Vol. 19; no. 10; p. e0313139
• Main Authors: Stanworth, Mark, Zhang, Shu-Dong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.10.2024; Public Library of Science (PLoS)
• Subjects: ADNP protein; Amino acids; Analysis; Aquaporins; Binding sites; Biology and Life Sciences; Biomarkers; Cancer; Colorectal cancer; Computational biology; Computational Biology - methods; Connective tissue diseases; Connective tissues; Copper; Correlation analysis; Disease; Disorders; Ehlers-Danlos syndrome; Elastin microfibril interface located protein; Extracellular matrix; Gene expression; Gene Ontology; Genes; Genetic disorders; Genomic analysis; Glaucoma; Holt-Oram syndrome; Humans; Hydrogen peroxide; Literature reviews; Medical prognosis; Medicine and Health Sciences; Metabolites; Neuropathy; Normal distribution; Ontology; Oxidative stress; Oxidative Stress - genetics; Oxygen; Phenotypes; Properties; Rare diseases; Rare Diseases - genetics; Rare species; Reactive oxygen species; Reactive Oxygen Species - metabolism; Retinoblastoma; Smooth muscle; Software; Species diffusion; Superoxide dismutase; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Therapeutic targets; Ireland

Superoxide Dismutase 3 (SOD3) scavenges extracellular superoxide giving a hydrogen peroxide metabolite. Both Reactive Oxygen Species diffuse through aquaporins causing oxidative stress and biomolecular damage. SOD3 is differentially expressed in cancer and this research utilises Gene Expression Omni...