Timed hazard networks: Incorporating temporal difference for oncogenetic analysis

• Published in: PloS one Vol. 18; no. 3; p. e0283004
• Main Author: Chen, Jian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.03.2023; Public Library of Science (PLoS)
• Subjects: Accumulation; Algorithms; Back propagation; Biology and Life Sciences; Breast cancer; Breast Neoplasms - genetics; Cancer; Carcinogenesis; Cell Transformation, Neoplastic; Computer Simulation; DNA methylation; Ecology and Environmental Sciences; Female; Genetic aspects; Humans; Markov analysis; Markov chains; Mathematical models; Medicine and Health Sciences; Methods; Modelling; Mutation; Oncogenes; Optimization; Performance evaluation; Physical Sciences; Playgrounds; Reproducibility of Results; Research and Analysis Methods; Statistical analysis; Statistical models; Temporal variations; United States

Oncogenetic graphical models are crucial for understanding cancer progression by analyzing the accumulation of genetic events. These models are used to identify statistical dependencies and temporal order of genetic events, which helps design targeted therapies. However, existing algorithms do not a...