Adaptation and Mal-Adaptation to Ambient Hypoxia; Andean, Ethiopian and Himalayan Patterns

• Published in: PloS one Vol. 3; no. 6; p. e2342
• Main Authors: Xing, Guoqiang, Qualls, Clifford, Huicho, Luis, River-Ch, Maria, Stobdan, Tsering, Slessarev, Marat, Prisman, Eitan, Ito, Soji, Wu, Hong, Norboo, Angchuk, Dolma, Diskit, Kunzang, Moses, Norboo, Tsering, Gamboa, Jorge L., Claydon, Victoria E., Fisher, Joseph, Zenebe, Guta, Gebremedhin, Amha, Hainsworth, Roger, Verma, Ajay, Appenzeller, Otto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.06.2008; Public Library of Science (PLoS)
• Subjects: Adaptation; Adaptation, Physiological - genetics; Altitude; Altitude sickness; Altitude Sickness - genetics; Altitude Sickness - physiopathology; Alzheimer's disease; Alzheimers disease; Analysis; Anesthesiology; Angiogenesis; Biological evolution; Biology; Blood cells; Cardiovascular Disorders; Cerebral blood flow; Cohort Studies; Drug dosages; Emergency medical care; Erythrocytes; Ethiopia; Evolution (Biology); Evolutionary biology; Evolutionary Biology/Human Evolution; Fitness; Gene expression; Genes; Genetics; Health sciences; Heat shock proteins; Homeostasis; Hyperoxia; Hypoxia; Hypoxia - genetics; Hypoxia - physiopathology; Kinases; Leukocytes; Medicine; Molecular Biology; Molecular Biology/Post-Translational Regulation of Gene Expression; Nepal; Neurology; Neurotoxicity; Peru; Physiology; Physiology/Cardiovascular Physiology and Circulation; Population studies; Populations; Reproductive fitness; Sea level; White blood cells; Canada; United States > US; New Mexico; Maryland; Japan; Kentucky

The study of the biology of evolution has been confined to laboratories and model organisms. However, controlled laboratory conditions are unlikely to model variations in environments that influence selection in wild populations. Thus, the study of "fitness" for survival and the genetics t...