Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging

• Published in: PloS one Vol. 18; no. 3; p. e0283612
• Main Authors: Zhao, Min, You, Baiyang, Wang, Xiaole, Huang, Jin, Zhou, Ming, Shi, Ruizheng, Zhang, Guogang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.03.2023; Public Library of Science (PLoS)
• Subjects: Abdomen; Animals; Aorta; Apoptosis; Arteriosclerosis; Atherogenesis; Atherosclerosis; Atherosclerosis - diagnostic imaging; Atherosclerosis - drug therapy; Atherosclerotic plaque; Atorvastatin; Atorvastatin - pharmacology; Atorvastatin - therapeutic use; Balloon treatment; Biology and Life Sciences; Cardiovascular disease; Care and treatment; Catheters; Cell number; Ceramide; Cholesterol; Chromatography; Computed tomography; Coronary vessels; Desipramine; Desipramine - pharmacology; Diagnosis; Drug dosages; Enzymes; Health aspects; High cholesterol diet; Histochemistry; Immunohistochemistry; In vivo methods and tests; Lipids; Liquid chromatography; Low density lipoprotein; Macrophages; Matrix metalloproteinase; Matrix metalloproteinases; Medical imaging; Medicine and Health Sciences; Metalloproteinase; Molecular Imaging; Oral administration; Plaque, Atherosclerotic - diagnostic imaging; Plaque, Atherosclerotic - drug therapy; Plasma; Rabbits; Research and Analysis Methods; Single photon emission computed tomography; Smooth muscle; Sphingomyelin phosphodiesterase; Stability; Statins; Veins & arteries; China; New Zealand; United States > US

Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro. Here, we aim to determine whether ASM-mediated apoptosis in plaque improves stability in vivo. In th...