Not All Missed Doses Are the Same: Sustained NNRTI Treatment Interruptions Predict HIV Rebound at Low-to-Moderate Adherence Levels

• Published in: PloS one Vol. 3; no. 7; p. e2783
• Main Authors: Parienti, Jean-Jacques, Das-Douglas, Moupali, Massari, Véronique, Guzman, David, Deeks, Steven G., Verdon, Renaud, Bangsberg, David R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.07.2008; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adhesion; Adult; Adults; AIDS; Anti-HIV Agents - therapeutic use; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiretroviral Therapy, Highly Active; Biological products industry; Case-Control Studies; Clinical trials; Cohort Studies; Confidence intervals; Disease prevention; DNA polymerases; Drug dosages; Drug resistance; Drug therapy; Drugs; Efavirenz; Epidemiology; Female; Health care access; Health risks; Highly active antiretroviral therapy; HIV; HIV - metabolism; HIV Infections - drug therapy; Hospitals; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Infectious Diseases/HIV Infection and AIDS; Interruption; Male; Microelectromechanical systems; Middle Aged; Monitoring systems; Nevirapine; Odds Ratio; Patient Compliance; Plasma; Public Health and Epidemiology/Infectious Diseases; Reverse Transcriptase Inhibitors - pharmacology; Ribonucleic acid; Risk assessment; Risk reduction; RNA; RNA, Viral - metabolism; RNA-directed DNA polymerase; Studies; Therapy; Virology/Antivirals, including Modes of Action and Resistance; San Francisco California; California; France; United States > US; Massachusetts

While the relationship between average adherence to HIV potent antiretroviral therapy is well defined, the relationship between patterns of adherence within adherence strata has not been investigated. We examined medication event monitoring system (MEMS) defined adherence patterns and their relation...