A predicted structure of NADPH Oxidase 1 identifies key components of ROS generation and strategies for inhibition

• Published in: PloS one Vol. 18; no. 5; p. e0285206
• Main Authors: Liu, Yezhou, Liang, Shiyu, Shi, Danfeng, Zhang, Yue, Bai, Chen, Ye, Richard D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.05.2023; Public Library of Science (PLoS)
• Subjects: Algorithms; Analysis; Antibodies; Binding; Biology and Life Sciences; Biotechnology; Cell culture; Cloning; Deep learning; DNA; Domains; Drug development; Electron transfer; Electron transport; Electron transport chain; Enzymes; Epithelial cells; Epithelium; Health aspects; Heme; Inhibitors; Membranes; Microenvironments; Modelling; Molecular docking; Molecular Docking Simulation; Mutagenesis; NAD(P)H oxidase; NADH, NADPH Oxidoreductases - metabolism; NADP; NADPH Oxidase 1 - genetics; NADPH Oxidases - metabolism; Oxidase; Oxidases; Oxygen; Pathogenesis; Physical Sciences; Plasmids; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reagents; Research and Analysis Methods; Site-directed mutagenesis; Substrates; China; St Louis Missouri; United Kingdom > UK; United States > US

NADPH oxidase 1 (NOX1) is primarily expressed in epithelial cells and responsible for local generation of reactive oxygen species (ROS). By specifically manipulating the local redox microenvironment, NOX1 actively engages in epithelial immunity, especially in colorectal and pulmonary epithelia. To u...