Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study

To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals acr...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 18; no. 6; p. e0285748
Main Authors Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa, Dellinger, Phil, Casey, Jonathan D, Park, Isabel, Gupta, Shruti, Baron, Rebecca M, Shaefi, Shahzad, Hunter, Krystal, Leaf, David E
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 28.06.2023
Public Library of Science (PLoS)
Subjects
Adult
Adults
Analysis
Artificial respiration
Biology and Life Sciences
Body mass index
Cardiovascular disease
Care and treatment
Cohort analysis
Cohort Studies
Complications and side effects
Coronaviruses
COVID-19
COVID-19 - therapy
Critical Illness
Critically ill
Death
Humans
Illnesses
Inflammation
Intubation
Investigations
Laboratories
Lung diseases
Male
Mechanical ventilation
Medicine and Health Sciences
Middle Aged
Missing data
Mortality
Patient outcomes
Patients
Physical Sciences
Research and Analysis Methods
Respiration, Artificial
Respiratory failure
SARS-CoV-2
Variables
Ventilation
Ventilators
United States
Online AccessGet full text

Cover

Abstract To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model. Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]). In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
AbstractList To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model. Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]). In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
Purpose To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. Materials and methods The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model. Results Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]). Conclusions In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model. Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]). In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.PURPOSETo investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model.MATERIALS AND METHODSThe data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model.Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]).RESULTSAmong the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]).In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.CONCLUSIONSIn critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
PurposeTo investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.Materials and methodsThe data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model.ResultsAmong the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]).ConclusionsIn critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
Purpose To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. Materials and methods The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1–2) versus late (ICU days 3–7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model. Results Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53–72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65–0.93]). Conclusions In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
Audience Academic
Author Baron, Rebecca M
Rachoin, Jean-Sebastien
Shaefi, Shahzad
Schorr, Christa
Gupta, Shruti
Park, Isabel
Leaf, David E
Green, Adam
Hunter, Krystal
Dellinger, Phil
Casey, Jonathan D
AuthorAffiliation 4 Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America
3 Division of Renal Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America
Universidad de La Sabana, COLOMBIA
5 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America
1 Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
2 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America
AuthorAffiliation_xml – name: 5 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America
– name: 1 Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
– name: 4 Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America
– name: 2 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America
– name: Universidad de La Sabana, COLOMBIA
– name: 3 Division of Renal Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America
Author_xml – sequence: 1
  givenname: Adam
  orcidid: 0000-0003-2562-746X
  surname: Green
  fullname: Green, Adam
  organization: Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
– sequence: 2
  givenname: Jean-Sebastien
  surname: Rachoin
  fullname: Rachoin, Jean-Sebastien
  organization: Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
– sequence: 3
  givenname: Christa
  surname: Schorr
  fullname: Schorr, Christa
  organization: Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
– sequence: 4
  givenname: Phil
  surname: Dellinger
  fullname: Dellinger, Phil
  organization: Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
– sequence: 5
  givenname: Jonathan D
  surname: Casey
  fullname: Casey, Jonathan D
  organization: Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America
– sequence: 6
  givenname: Isabel
  surname: Park
  fullname: Park, Isabel
  organization: Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, United States of America
– sequence: 7
  givenname: Shruti
  surname: Gupta
  fullname: Gupta, Shruti
  organization: Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, United States of America
– sequence: 8
  givenname: Rebecca M
  surname: Baron
  fullname: Baron, Rebecca M
  organization: Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, United States of America
– sequence: 9
  givenname: Shahzad
  surname: Shaefi
  fullname: Shaefi, Shahzad
  organization: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America
– sequence: 10
  givenname: Krystal
  orcidid: 0000-0002-8991-2625
  surname: Hunter
  fullname: Hunter, Krystal
  organization: Cooper University Health Care and Cooper Medical School of Rowan University, Camden, NJ, United States of America
– sequence: 11
  givenname: David E
  orcidid: 0000-0001-7875-090X
  surname: Leaf
  fullname: Leaf, David E
  organization: Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, United States of America
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37379286$$D View this record in MEDLINE/PubMed
BookMark eNqNk1tv0zAUxyM0xC7wDRBYQkLw0OJLnDi8oKrcKk2qBGOv1qnjtJ6cuIudQr89zppNDdoD8oOt49_5n4t9zpOTxjU6SV4SPCUsJx9uXNc2YKfbaJ5iKnieiifJGSkYnWQUs5Oj82ly7v0NxpyJLHuWnLKc5QUV2VmyuzK1adbIVcg0O_Bmp1Gt1QYao8CinW6CsRCMaxA0JSo1hE0kkWpN6Am7R8ZaBGVng0e_TbydL68Xnyek-IhmqI5mo6KIbpFyG9cG5ENX7p8nTyuwXr8Y9ovk19cvV_Pvk8vlt8V8djlRWcHChHKxUhmHFStIRUmOWaqZEhyKtCClyEtBKpxqCpUWWHGhWFlpnlFKCckUzdhF8vqgu7XOy6FlXlLBcIYJxzgSiwNROriR29bU0O6lAyPvDK5dS2hjDVZLxnhaFkCJ1pCmJYiqyvOMq5yTPNVcRa1PQ7RuVeuyr7sFOxId3zRmI9duJwmO-cSco8K7QaF1t532QdbGK20tNNp1d4kTWuSY9om_-Qd9vLyBWkOswDSVi4FVLypnOY8EoZhGavoIFVepa6PiB6tMtI8c3o8cIhP0n7CGznu5-Pnj_9nl9Zh9e8RuNNiw8c52_Qf0YzA9gKp13re6eugywbKfj_tuyH4-5DAf0e3V8Qs9ON0PBPsL5WULQQ
CitedBy_id crossref_primary_10_3390_jcm13071833
Cites_doi 10.1007/BF00255628
10.1164/rccm.202104-0860LE
10.1056/NEJMoa2021436
10.1097/CCE.0000000000000385
10.1007/BF01709751
10.1016/j.mayocp.2017.07.001
10.1007/s00134-020-06294-x
10.1056/NEJMoa2100433
10.1186/s13613-020-00708-1
10.1016/j.ijmedinf.2017.04.001
10.1001/jama.2016.20328
10.1001/jama.2020.6825
10.1007/s00134-015-3693-5
10.1186/s13613-020-00668-6
10.1186/s13054-021-03580-y
10.1016/S0140-6736(22)00519-0
10.1186/s13054-021-03540-6
10.1001/jamainternmed.2020.3539
10.1097/RHU.0b013e31829ce01f
10.1001/jamainternmed.2020.6252
10.1186/s13054-022-03995-1
10.1016/j.jcrc.2021.06.008
10.1016/j.jcrc.2022.154062
10.1097/CCE.0000000000000254
10.1056/NEJMoa2103417
10.7326/M20-6739
10.1161/JAHA.117.008169
10.1186/s13054-021-03882-1
10.1097/CCM.0000000000004879
10.1186/s13613-020-00692-6
10.1164/rccm.201605-1081CP
10.1001/jama.2022.21383
10.1016/j.jcrc.2017.06.010
ContentType Journal Article
Contributor Chan, Lili
Boateng, Jeffery O
Upadhyay, Shristi
Williams, Aquino
Saha, Aparna
Wen, Huei Hsun
Hart, Peter
Melaku, Yohannes
Kelly, Katherine J
Valencia, Juan D
Green, Adam
Cohen, Zaza
Friedman, Allon N
Kamal, Omer
Nadkarni, Girish N
Mallappallil, Mary C
Shaefi, Shahzad
Ahoubim, Afshin
Mosher, Christopher L
Edmonston, Daniel L
Thaxton, Mariah
Mehta, Bijal
Pannu, Ameeka
Mohamed, Ibrahim
Newman, Erik T
Sirganagari, Dheeraj Reddy
Wen, Yumeng
Milligan, Gregory P
Rachoin, Jean-Sebastien
Sharma, Shreyak
Corona-Villalobos, Celia P
Correa, Simon
Mathews, Kusum S
Omar, Samah Abu
Kopecky, Kathleen F
Yang, Heather
Boudourakis, Leon
Menez, Steven
Ouyang, Jie
Go, Ronaldo C
Soh, Howard
Malik, Rubab F
Li, Jiahua
Gallagher, Emily J
Nguyen, H Bryant
Parikh, Chirag R
Singh, Harkarandeep
Kapoor, Rajat
Wagner, John
Lee, Meghan
Cervantes, Elena
Shea, Lisa
Guirguis, John
Gautam, Samir
Lisk, Rebecca
Anumudu, Samaya J
Rose, Keith M
Schorr, Christa A
Walther, Carl P
Gupta, Shruti
Kim, Ethan C
Altman, Deena R
Nguyen, Thuy-Duyen
Thomas, Leslie F
Bambrick-Santoyo, Gabriela
Zhou,
Contributor_xml – sequence: 1
  givenname: Carl P
  surname: Walther
  fullname: Walther, Carl P
– sequence: 2
  givenname: Samaya J
  surname: Anumudu
  fullname: Anumudu, Samaya J
– sequence: 3
  givenname: Justin
  surname: Arunthamakun
  fullname: Arunthamakun, Justin
– sequence: 4
  givenname: Kathleen F
  surname: Kopecky
  fullname: Kopecky, Kathleen F
– sequence: 5
  givenname: Gregory P
  surname: Milligan
  fullname: Milligan, Gregory P
– sequence: 6
  givenname: Peter A
  surname: McCullough
  fullname: McCullough, Peter A
– sequence: 7
  givenname: Thuy-Duyen
  surname: Nguyen
  fullname: Nguyen, Thuy-Duyen
– sequence: 8
  givenname: Shahzad
  surname: Shaefi
  fullname: Shaefi, Shahzad
– sequence: 9
  givenname: Megan L
  surname: Krajewski
  fullname: Krajewski, Megan L
– sequence: 10
  givenname: Sidharth
  surname: Shankar
  fullname: Shankar, Sidharth
– sequence: 11
  givenname: Ameeka
  surname: Pannu
  fullname: Pannu, Ameeka
– sequence: 12
  givenname: Juan D
  surname: Valencia
  fullname: Valencia, Juan D
– sequence: 13
  givenname: Sushrut S
  surname: Waikar
  fullname: Waikar, Sushrut S
– sequence: 14
  givenname: Zoe A
  surname: Kibbelaar
  fullname: Kibbelaar, Zoe A
– sequence: 15
  givenname: Ambarish M
  surname: Athavale
  fullname: Athavale, Ambarish M
– sequence: 16
  givenname: Peter
  surname: Hart
  fullname: Hart, Peter
– sequence: 17
  givenname: Shristi
  surname: Upadhyay
  fullname: Upadhyay, Shristi
– sequence: 18
  givenname: Ishaan
  surname: Vohra
  fullname: Vohra, Ishaan
– sequence: 19
  givenname: Adam
  surname: Green
  fullname: Green, Adam
– sequence: 20
  givenname: Jean-Sebastien
  surname: Rachoin
  fullname: Rachoin, Jean-Sebastien
– sequence: 21
  givenname: Christa A
  surname: Schorr
  fullname: Schorr, Christa A
– sequence: 22
  givenname: Lisa
  surname: Shea
  fullname: Shea, Lisa
– sequence: 23
  givenname: Daniel L
  surname: Edmonston
  fullname: Edmonston, Daniel L
– sequence: 24
  givenname: Christopher L
  surname: Mosher
  fullname: Mosher, Christopher L
– sequence: 25
  givenname: Alexandre M
  surname: Shehata
  fullname: Shehata, Alexandre M
– sequence: 26
  givenname: Zaza
  surname: Cohen
  fullname: Cohen, Zaza
– sequence: 27
  givenname: Valerie
  surname: Allusson
  fullname: Allusson, Valerie
– sequence: 28
  givenname: Gabriela
  surname: Bambrick-Santoyo
  fullname: Bambrick-Santoyo, Gabriela
– sequence: 29
  givenname: Noor Ul Aain
  surname: Bhatti
  fullname: Bhatti, Noor Ul Aain
– sequence: 30
  givenname: Bijal
  surname: Mehta
  fullname: Mehta, Bijal
– sequence: 31
  givenname: Aquino
  surname: Williams
  fullname: Williams, Aquino
– sequence: 32
  givenname: Samantha K
  surname: Brenner
  fullname: Brenner, Samantha K
– sequence: 33
  givenname: Patricia
  surname: Walters
  fullname: Walters, Patricia
– sequence: 34
  givenname: Ronaldo C
  surname: Go
  fullname: Go, Ronaldo C
– sequence: 35
  givenname: Keith M
  surname: Rose
  fullname: Rose, Keith M
– sequence: 36
  givenname: Miguel A
  surname: Hernán
  fullname: Hernán, Miguel A
– sequence: 37
  givenname: Rebecca
  surname: Lisk
  fullname: Lisk, Rebecca
– sequence: 38
  givenname: Amy M
  surname: Zhou
  fullname: Zhou, Amy M
– sequence: 39
  givenname: Ethan C
  surname: Kim
  fullname: Kim, Ethan C
– sequence: 40
  givenname: Lili
  surname: Chan
  fullname: Chan, Lili
– sequence: 41
  givenname: Kusum S
  surname: Mathews
  fullname: Mathews, Kusum S
– sequence: 42
  givenname: Steven G
  surname: Coca
  fullname: Coca, Steven G
– sequence: 43
  givenname: Deena R
  surname: Altman
  fullname: Altman, Deena R
– sequence: 44
  givenname: Aparna
  surname: Saha
  fullname: Saha, Aparna
– sequence: 45
  givenname: Howard
  surname: Soh
  fullname: Soh, Howard
– sequence: 46
  givenname: Huei Hsun
  surname: Wen
  fullname: Wen, Huei Hsun
– sequence: 47
  givenname: Sonali
  surname: Bose
  fullname: Bose, Sonali
– sequence: 48
  givenname: Emily A
  surname: Leven
  fullname: Leven, Emily A
– sequence: 49
  givenname: Jing G
  surname: Wang
  fullname: Wang, Jing G
– sequence: 50
  givenname: Gohar
  surname: Mosoyan
  fullname: Mosoyan, Gohar
– sequence: 51
  givenname: Girish N
  surname: Nadkarni
  fullname: Nadkarni, Girish N
– sequence: 52
  givenname: Pattharawin
  surname: Pattharanitima
  fullname: Pattharanitima, Pattharawin
– sequence: 53
  givenname: Emily J
  surname: Gallagher
  fullname: Gallagher, Emily J
– sequence: 54
  givenname: Allon N
  surname: Friedman
  fullname: Friedman, Allon N
– sequence: 55
  givenname: John
  surname: Guirguis
  fullname: Guirguis, John
– sequence: 56
  givenname: Rajat
  surname: Kapoor
  fullname: Kapoor, Rajat
– sequence: 57
  givenname: Christopher
  surname: Meshberger
  fullname: Meshberger, Christopher
– sequence: 58
  givenname: Katherine J
  surname: Kelly
  fullname: Kelly, Katherine J
– sequence: 59
  givenname: Chirag R
  surname: Parikh
  fullname: Parikh, Chirag R
– sequence: 60
  givenname: Brian T
  surname: Garibaldi
  fullname: Garibaldi, Brian T
– sequence: 61
  givenname: Celia P
  surname: Corona-Villalobos
  fullname: Corona-Villalobos, Celia P
– sequence: 62
  givenname: Yumeng
  surname: Wen
  fullname: Wen, Yumeng
– sequence: 63
  givenname: Steven
  surname: Menez
  fullname: Menez, Steven
– sequence: 64
  givenname: Rubab F
  surname: Malik
  fullname: Malik, Rubab F
– sequence: 65
  givenname: Elena
  surname: Cervantes
  fullname: Cervantes, Elena
– sequence: 66
  givenname: Samir
  surname: Gautam
  fullname: Gautam, Samir
– sequence: 67
  givenname: Mary C
  surname: Mallappallil
  fullname: Mallappallil, Mary C
– sequence: 68
  givenname: Jie
  surname: Ouyang
  fullname: Ouyang, Jie
– sequence: 69
  givenname: Sabu
  surname: John
  fullname: John, Sabu
– sequence: 70
  givenname: Ernie
  surname: Yap
  fullname: Yap, Ernie
– sequence: 71
  givenname: Yohannes
  surname: Melaku
  fullname: Melaku, Yohannes
– sequence: 72
  givenname: Ibrahim
  surname: Mohamed
  fullname: Mohamed, Ibrahim
– sequence: 73
  givenname: Siddartha
  surname: Bajracharya
  fullname: Bajracharya, Siddartha
– sequence: 74
  givenname: Isha
  surname: Puri
  fullname: Puri, Isha
– sequence: 75
  givenname: Mariah
  surname: Thaxton
  fullname: Thaxton, Mariah
– sequence: 76
  givenname: Jyotsna
  surname: Bhattacharya
  fullname: Bhattacharya, Jyotsna
– sequence: 77
  givenname: John
  surname: Wagner
  fullname: Wagner, John
– sequence: 78
  givenname: Leon
  surname: Boudourakis
  fullname: Boudourakis, Leon
– sequence: 79
  givenname: H Bryant
  surname: Nguyen
  fullname: Nguyen, H Bryant
– sequence: 80
  givenname: Afshin
  surname: Ahoubim
  fullname: Ahoubim, Afshin
– sequence: 81
  givenname: David E
  surname: Leaf
  fullname: Leaf, David E
– sequence: 82
  givenname: Shruti
  surname: Gupta
  fullname: Gupta, Shruti
– sequence: 83
  givenname: Meghan E
  surname: Sise
  fullname: Sise, Meghan E
– sequence: 84
  givenname: Erik T
  surname: Newman
  fullname: Newman, Erik T
– sequence: 85
  givenname: Samah Abu
  surname: Omar
  fullname: Omar, Samah Abu
– sequence: 86
  givenname: Kapil K
  surname: Pokharel
  fullname: Pokharel, Kapil K
– sequence: 87
  givenname: Shreyak
  surname: Sharma
  fullname: Sharma, Shreyak
– sequence: 88
  givenname: Harkarandeep
  surname: Singh
  fullname: Singh, Harkarandeep
– sequence: 89
  givenname: Simon
  surname: Correa
  fullname: Correa, Simon
– sequence: 90
  givenname: Tanveer
  surname: Shaukat
  fullname: Shaukat, Tanveer
– sequence: 91
  givenname: Omer
  surname: Kamal
  fullname: Kamal, Omer
– sequence: 92
  givenname: Wei
  surname: Wang
  fullname: Wang, Wei
– sequence: 93
  givenname: Heather
  surname: Yang
  fullname: Yang, Heather
– sequence: 94
  givenname: Jeffery O
  surname: Boateng
  fullname: Boateng, Jeffery O
– sequence: 95
  givenname: Meghan
  surname: Lee
  fullname: Lee, Meghan
– sequence: 96
  givenname: Ian A
  surname: Strohbehn
  fullname: Strohbehn, Ian A
– sequence: 97
  givenname: Jiahua
  surname: Li
  fullname: Li, Jiahua
– sequence: 98
  givenname: Ariel L
  surname: Mueller
  fullname: Mueller, Ariel L
– sequence: 99
  givenname: Leslie F
  surname: Thomas
  fullname: Thomas, Leslie F
– sequence: 100
  givenname: Dheeraj Reddy
  surname: Sirganagari
  fullname: Sirganagari, Dheeraj Reddy
Copyright Copyright: © 2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2023 Public Library of Science
2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 Green et al 2023 Green et al
2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: Copyright: © 2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
– notice: COPYRIGHT 2023 Public Library of Science
– notice: 2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 Green et al 2023 Green et al
– notice: 2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
CorporateAuthor STOP-COVID Investigators
for the STOP-COVID Investigators
CorporateAuthor_xml – sequence: 0
  name: for the STOP-COVID Investigators
– name: STOP-COVID Investigators
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
COVID
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PIMPY
PQEST
PQQKQ
PQUKI
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0285748
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Gale In Context: Opposing Viewpoints
Science in Context
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
Coronavirus Research Database
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agriculture Science Database
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
Coronavirus Research Database
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
Technology Collection
Technology Research Database
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

MEDLINE
MEDLINE - Academic


Agricultural Science Database
Database_xml – sequence: 1
  dbid: DOA
  name: Open Access: DOAJ - Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
DocumentTitleAlternate Timing of IMV in COVID-19
EISSN 1932-6203
Editor Reyes, Luis Felipe
Editor_xml – sequence: 1
  givenname: Luis Felipe
  surname: Reyes
  fullname: Reyes, Luis Felipe
ExternalDocumentID 2830601500
oai_doaj_org_article_3354d9a21eea44da8ff7765c75174e5c
A755001202
10_1371_journal_pone_0285748
37379286
Genre Multicenter Study
Journal Article
GeographicLocations United States
GeographicLocations_xml – name: United States
GrantInformation_xml – fundername: NIH HHS
  grantid: S10 OD030463
– fundername: NIH HHS
  grantid: S10 OD026880
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BBORY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
ECM
EIF
EMOBN
ESTFP
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
P62
PATMY
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RIG
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
AAYXX
CITATION
AFPKN
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
COVID
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PQEST
PQUKI
RC3
7X8
5PM
AAPBV
ABPTK
ID FETCH-LOGICAL-c693t-258bc65ab391f217034e3c85a9491d87d81f04e2afe80c58c3dfe56222116c263
IEDL.DBID RPM
ISSN 1932-6203
IngestDate Sun Sep 03 00:14:17 EDT 2023
Tue Oct 22 15:15:46 EDT 2024
Tue Sep 17 21:30:02 EDT 2024
Sat Oct 26 04:44:07 EDT 2024
Thu Oct 10 15:59:22 EDT 2024
Tue Nov 19 21:03:18 EST 2024
Tue Nov 12 22:52:42 EST 2024
Sat Sep 28 21:04:03 EDT 2024
Sat Sep 28 21:39:30 EDT 2024
Tue Aug 20 22:06:51 EDT 2024
Fri Dec 06 01:51:46 EST 2024
Sat Nov 02 12:09:10 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License Copyright: © 2023 Green et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c693t-258bc65ab391f217034e3c85a9491d87d81f04e2afe80c58c3dfe56222116c263
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
A full list of the STOP-COVID investigators is provided in the supplemental material.
ORCID 0000-0001-7875-090X
0000-0002-8991-2625
0000-0003-2562-746X
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306211/
PMID 37379286
PQID 2830601500
PQPubID 1436336
PageCount e0285748
ParticipantIDs plos_journals_2830601500
doaj_primary_oai_doaj_org_article_3354d9a21eea44da8ff7765c75174e5c
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10306211
proquest_miscellaneous_2831297020
proquest_journals_2830601500
gale_infotracmisc_A755001202
gale_infotracacademiconefile_A755001202
gale_incontextgauss_ISR_A755001202
gale_incontextgauss_IOV_A755001202
gale_healthsolutions_A755001202
crossref_primary_10_1371_journal_pone_0285748
pubmed_primary_37379286
PublicationCentury 2000
PublicationDate 2023-06-28
PublicationDateYYYYMMDD 2023-06-28
PublicationDate_xml – month: 06
  year: 2023
  text: 2023-06-28
  day: 28
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2023
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References A Landry (pone.0285748.ref021) 2017; 63
M Vera (pone.0285748.ref025) 2021; 65
C Darreau (pone.0285748.ref036) 2020; 10
T Herold (pone.0285748.ref020) 2020
S Gupta (pone.0285748.ref031) 2021; 181
PR Bauer (pone.0285748.ref035) 2017; 92
D Mascheroni (pone.0285748.ref008) 1988; 15
JP Domecq (pone.0285748.ref002) 2021; 49
JB Hyman (pone.0285748.ref011) 2020; 2
NA Xixi (pone.0285748.ref028) 2022; 71
H Al-Samkari (pone.0285748.ref032) 2021; 174
Recovery Collaborative Group (pone.0285748.ref003) 2021; 384
C Jr Moore (pone.0285748.ref022) 2013; 19
MC Sklar (pone.0285748.ref033) 2021; 204
L Gattinoni (pone.0285748.ref007) 2020; 10
JC Jentzer (pone.0285748.ref018) 2018; 7
REMAP-CAP Investigators (pone.0285748.ref004) 2021; 384
CJ Yarnell (pone.0285748.ref034) 2021; 3
J Gonzalez (pone.0285748.ref015) 2022; 26
L Brochard (pone.0285748.ref009) 2017; 195
G Grasselli (pone.0285748.ref024) 2020; 180
MA Hernan (pone.0285748.ref013) 2022; 328
E Papoutsi (pone.0285748.ref012) 2021; 25
WHO Solidarity Trial Consortium (pone.0285748.ref005) 2022; 399
(pone.0285748.ref023) 2021; 47
MM Churpek (pone.0285748.ref029) 2021
PD Wendel Garcia (pone.0285748.ref026) 2021; 25
C Aakre (pone.0285748.ref019) 2017; 103
R Yamamoto (pone.0285748.ref037) 2022; 26
MJ Tobin (pone.0285748.ref010) 2020; 10
JJ Marini (pone.0285748.ref006) 2020; 323
PR Bauer (pone.0285748.ref014) 2017; 42
REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators (pone.0285748.ref030) 2021; 385
S Gupta (pone.0285748.ref001) 2020
JL Vincent (pone.0285748.ref016) 1996; 22
EP Raith (pone.0285748.ref017) 2017; 317
BJ Kang (pone.0285748.ref027) 2015; 41
References_xml – volume: 15
  start-page: 8
  issue: 1
  year: 1988
  ident: pone.0285748.ref008
  article-title: Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study
  publication-title: Intensive Care Med
  doi: 10.1007/BF00255628
  contributor:
    fullname: D Mascheroni
– year: 2020
  ident: pone.0285748.ref020
  article-title: Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: T Herold
– year: 2021
  ident: pone.0285748.ref029
  article-title: Hospital-Level Variation in Death for Critically Ill Patients with COVID-19
  publication-title: Am J Respir Crit Care Med
  contributor:
    fullname: MM Churpek
– volume: 204
  start-page: 737
  issue: 6
  year: 2021
  ident: pone.0285748.ref033
  article-title: Always Say Never: Why Studies of Timing of Invasive Ventilation Should Compare "Early versus Late/Never" as Opposed to "Early versus Late"
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.202104-0860LE
  contributor:
    fullname: MC Sklar
– volume: 384
  start-page: 693
  issue: 8
  year: 2021
  ident: pone.0285748.ref003
  article-title: Dexamethasone in Hospitalized Patients with Covid-19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2021436
  contributor:
    fullname: Recovery Collaborative Group
– volume: 3
  start-page: e0385
  issue: 4
  year: 2021
  ident: pone.0285748.ref034
  article-title: Bias Due to Cohort Construction in the Study of Timing of Invasive Ventilation
  publication-title: Crit Care Explor
  doi: 10.1097/CCE.0000000000000385
  contributor:
    fullname: CJ Yarnell
– volume: 22
  start-page: 707
  issue: 7
  year: 1996
  ident: pone.0285748.ref016
  article-title: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine
  publication-title: Intensive Care Med
  doi: 10.1007/BF01709751
  contributor:
    fullname: JL Vincent
– volume: 92
  start-page: 1502
  issue: 10
  year: 2017
  ident: pone.0285748.ref035
  article-title: Timing of Intubation in Acute Respiratory Failure Associated With Sepsis: A Mixed Methods Study
  publication-title: Mayo Clin Proc
  doi: 10.1016/j.mayocp.2017.07.001
  contributor:
    fullname: PR Bauer
– volume: 47
  start-page: 60
  issue: 1
  year: 2021
  ident: pone.0285748.ref023
  article-title: Covid-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators. Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-020-06294-x
– volume: 384
  start-page: 1491
  issue: 16
  year: 2021
  ident: pone.0285748.ref004
  article-title: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2100433
  contributor:
    fullname: REMAP-CAP Investigators
– volume: 10
  start-page: 88
  issue: 1
  year: 2020
  ident: pone.0285748.ref007
  article-title: Spontaneous breathing, transpulmonary pressure and mathematical trickery
  publication-title: Ann Intensive Care
  doi: 10.1186/s13613-020-00708-1
  contributor:
    fullname: L Gattinoni
– volume: 103
  start-page: 1
  year: 2017
  ident: pone.0285748.ref019
  article-title: Prospective validation of a near real-time EHR-integrated automated SOFA score calculator
  publication-title: Int J Med Inform
  doi: 10.1016/j.ijmedinf.2017.04.001
  contributor:
    fullname: C Aakre
– volume: 63
  start-page: e316
  issue: 6
  year: 2017
  ident: pone.0285748.ref021
  article-title: Causes and outcomes of markedly elevated C-reactive protein levels
  publication-title: Can Fam Physician
  contributor:
    fullname: A Landry
– volume: 317
  start-page: 290
  issue: 3
  year: 2017
  ident: pone.0285748.ref017
  article-title: Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit
  publication-title: JAMA
  doi: 10.1001/jama.2016.20328
  contributor:
    fullname: EP Raith
– volume: 323
  start-page: 2329
  issue: 22
  year: 2020
  ident: pone.0285748.ref006
  article-title: Management of COVID-19 Respiratory Distress
  publication-title: JAMA
  doi: 10.1001/jama.2020.6825
  contributor:
    fullname: JJ Marini
– volume: 41
  start-page: 623
  issue: 4
  year: 2015
  ident: pone.0285748.ref027
  article-title: Failure of high-flow nasal cannula therapy may delay intubation and increase mortality
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-015-3693-5
  contributor:
    fullname: BJ Kang
– volume: 10
  start-page: 62
  issue: 1
  year: 2020
  ident: pone.0285748.ref036
  article-title: Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study
  publication-title: Ann Intensive Care
  doi: 10.1186/s13613-020-00668-6
  contributor:
    fullname: C Darreau
– volume: 25
  start-page: 175
  issue: 1
  year: 2021
  ident: pone.0285748.ref026
  article-title: Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort
  publication-title: Crit Care
  doi: 10.1186/s13054-021-03580-y
  contributor:
    fullname: PD Wendel Garcia
– volume: 399
  start-page: 1941
  issue: 10339
  year: 2022
  ident: pone.0285748.ref005
  article-title: Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)00519-0
  contributor:
    fullname: WHO Solidarity Trial Consortium
– volume: 25
  start-page: 121
  issue: 1
  year: 2021
  ident: pone.0285748.ref012
  article-title: Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort sutdies
  publication-title: Crit Care
  doi: 10.1186/s13054-021-03540-6
  contributor:
    fullname: E Papoutsi
– volume: 180
  start-page: 1345
  issue: 10
  year: 2020
  ident: pone.0285748.ref024
  article-title: Risk Factors Associated With Mortality AMong Patients With COVID-19 in Intensive Care Units in Lombardy, Italy
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2020.3539
  contributor:
    fullname: G Grasselli
– volume: 19
  start-page: 324
  issue: 6
  year: 2013
  ident: pone.0285748.ref022
  article-title: Causes and significance of markedly elevated serum ferritin levels in an academic medical center
  publication-title: J Clin Rheumatol
  doi: 10.1097/RHU.0b013e31829ce01f
  contributor:
    fullname: C Jr Moore
– volume: 181
  start-page: 41
  issue: 1
  year: 2021
  ident: pone.0285748.ref031
  article-title: Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2020.6252
  contributor:
    fullname: S Gupta
– year: 2020
  ident: pone.0285748.ref001
  article-title: Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
  publication-title: JAMA Intern Med
  contributor:
    fullname: S Gupta
– volume: 26
  start-page: 124
  issue: 1
  year: 2022
  ident: pone.0285748.ref037
  article-title: Early intubation and decreased in-hospital mortality in patients with coronavirus disease 2019
  publication-title: Crit Care
  doi: 10.1186/s13054-022-03995-1
  contributor:
    fullname: R Yamamoto
– volume: 65
  start-page: 164
  year: 2021
  ident: pone.0285748.ref025
  article-title: Intubation timing as determinant of outcome in patients with acute respiratory distress syndrome by SARS-CoV-2 infection
  publication-title: J Crit Care
  doi: 10.1016/j.jcrc.2021.06.008
  contributor:
    fullname: M Vera
– volume: 71
  start-page: 154062
  year: 2022
  ident: pone.0285748.ref028
  article-title: Association between timing of intubation and clinical outcomes of critically ill patients: A meta-analysis
  publication-title: J Crit Care
  doi: 10.1016/j.jcrc.2022.154062
  contributor:
    fullname: NA Xixi
– volume: 2
  start-page: e0254
  issue: 10
  year: 2020
  ident: pone.0285748.ref011
  article-title: Timing of Intubation and In-Hospital Mortality in PatientsWith Cornoavirus Disease 2019
  publication-title: Crit Care Explor
  doi: 10.1097/CCE.0000000000000254
  contributor:
    fullname: JB Hyman
– volume: 385
  start-page: 777
  issue: 9
  year: 2021
  ident: pone.0285748.ref030
  article-title: Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2103417
  contributor:
    fullname: REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators
– volume: 174
  start-page: 622
  issue: 5
  year: 2021
  ident: pone.0285748.ref032
  article-title: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19
  publication-title: Ann Intern Med
  doi: 10.7326/M20-6739
  contributor:
    fullname: H Al-Samkari
– volume: 7
  issue: 6
  year: 2018
  ident: pone.0285748.ref018
  article-title: Predictive Value of the Sequential Organ Failure Assessment Score for Mortality in a Contemporary Cardiac Intensive Care Unit Population
  publication-title: J Am Heart Assoc
  doi: 10.1161/JAHA.117.008169
  contributor:
    fullname: JC Jentzer
– volume: 26
  start-page: 18
  issue: 1
  year: 2022
  ident: pone.0285748.ref015
  article-title: Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study
  publication-title: Crit Care
  doi: 10.1186/s13054-021-03882-1
  contributor:
    fullname: J Gonzalez
– volume: 49
  start-page: 437
  issue: 3
  year: 2021
  ident: pone.0285748.ref002
  article-title: Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry
  publication-title: Crit Care Med
  doi: 10.1097/CCM.0000000000004879
  contributor:
    fullname: JP Domecq
– volume: 10
  start-page: 78
  issue: 1
  year: 2020
  ident: pone.0285748.ref010
  article-title: Caution about early intubation and mechanical ventilation in COVID-19
  publication-title: Ann Intensive Care
  doi: 10.1186/s13613-020-00692-6
  contributor:
    fullname: MJ Tobin
– volume: 195
  start-page: 438
  issue: 4
  year: 2017
  ident: pone.0285748.ref009
  article-title: Mechanical Ventilation to Minimize Progression of Lung Injury in Acute Respiratory Failure
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201605-1081CP
  contributor:
    fullname: L Brochard
– volume: 328
  start-page: 2446
  issue: 24
  year: 2022
  ident: pone.0285748.ref013
  article-title: Target Trial Emulation: A Framework for Causal Inference From Observational Data
  publication-title: JAMA
  doi: 10.1001/jama.2022.21383
  contributor:
    fullname: MA Hernan
– volume: 42
  start-page: 1
  year: 2017
  ident: pone.0285748.ref014
  article-title: Association between timing of intubation and outcome in critically ill patients: A secondary analysis of the ICON audit
  publication-title: J Crit Care
  doi: 10.1016/j.jcrc.2017.06.010
  contributor:
    fullname: PR Bauer
SSID ssj0053866
Score 2.487101
Snippet To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The...
Purpose To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with...
To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The...
To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with...
PurposeTo investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with...
Purpose To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with...
SourceID plos
doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e0285748
SubjectTerms Adult
Adults
Analysis
Artificial respiration
Biology and Life Sciences
Body mass index
Cardiovascular disease
Care and treatment
Cohort analysis
Cohort Studies
Complications and side effects
Coronaviruses
COVID-19
COVID-19 - therapy
Critical Illness
Critically ill
Death
Humans
Illnesses
Inflammation
Intubation
Investigations
Laboratories
Lung diseases
Male
Mechanical ventilation
Medicine and Health Sciences
Middle Aged
Missing data
Mortality
Patient outcomes
Patients
Physical Sciences
Research and Analysis Methods
Respiration, Artificial
Respiratory failure
SARS-CoV-2
Variables
Ventilation
Ventilators
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fb9MwELZQn3hBjF8LG2AQEvCQLYkd2-GtDKYNCSbBNu0tcmxnVCpJ1bST-O-5c9yoQZPggdf6EiV339l36d13hLy2aWKZZklcG85jbpyIdVGx2DqpOee5LnxX2pev4uSCf77Kr7ZGfWFNWE8P3CvukLGc20JnqXNwsdWqrqUUuZFIsexy43ffJNskU_0eDF4sRGiUYzI9DHY5WLSNO4ATNZc472frIPJ8_cOuPFnM2-62kPPPysmto-j4PrkXYkg67Z99h9xxzQOyE7y0o28DlfS7h-TmHId2XdO2prPmRmOpOv3psNkXbUN9rWNfDEd1Y6nFeBAkqQkDEOa_6Gw-p56ko6P4zZYenV2efozT4j2dUl-NiA_plhQn7S5X1NPVPiIXx5_Oj07iMGkhNqJgqzjLVWVEritWpDUkKQnjjhkFluJFapW0Kq0T7jJdO5WYXBlmaweRUwbpozCZYI_JpAHd7hKqZCGQdJ1VDqnCsqrgdSVlklcWbmBlROKN2stFT6hR-n_VJCQivf5KNFMZzBSRD2ibQRbpsP0PAJIygKT8G0gi8gItW_a9pYNTl1MJCRq2D2cReeUlkBKjwZqba73uuvL07PIfhL5_Gwm9CUJ1CxgxOvQ5wDsh1dZIcn8kCY5tRsu7iMONVroSudoEfqFK4MoNNm9ffjks402xjq5x7drLQIAnIUeIyJMeyoNmmWSyyJSIiBqBfKT68Uoz--EZyXFWnQAsPP0fxtojd-HtceZInKl9Mlkt1-4ZRH6r6rl38t-YBVVL
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegvPCCGF8LDDAICXjIlsSO7fCCymBsSDAJtmlvkWM7pVJJStNO4r_nznHLgibEa3yJ7Puw75y73xHywqaJZZolcW04j7lxItZFxWLrpOac57rwVWmfv4jDU_7pPD8PF25dSKtc74l-o7atwTvyPQSqEhieJ2_nP2PsGoV_V0MLjevkRppJgSl96uDjeicGWxYilMsxme4F6ezO28btwrmaS-z6c-k48qj9m715NJ-13VWO59_5k5cOpIPb5FbwJOm4F_0WueaaO2Qr2GpHXwVA6dd3ycUJtu6a0Lam0-ZCY8I6_eGw5BclRH3GY58SR3VjqUWvECipCW0QZr_odDajHqqjo3hzS_ePz47ex2nxho6pz0nESboFxX67iyX1oLX3yOnBh5P9wzj0W4iNKNgyznJVGZHrihVpDaFKwrhjRoG8eJFaJa1K64S7TNdOJSZXhtnagf-UQRApTCbYfTJqgLfbhCpZCIReZ5VDwLCsKnhdSZnklYUPWBmReM32ct7DapT-35qEcKTnX4liKoOYIvIOZbOhRVBs_6BdTMpgYyVjObeFzlLnQM-sVnUtQSmMRDRul5uIPEXJln2F6ca0y7GEMA2LiLOIPPcUCIzRYObNRK-6rjw6PvsPom9fB0QvA1Hdgo4YHaodYE0IuDWg3BlQgnmbwfA26uGaK135xxDgzbVuXj38bDOMH8Vsusa1K08Dbp6ESCEiD3pV3nCWSSaLTImIqIGSD1g_HGmm3z0uOXasE6ALD_89r0fkJqwLe4rEmdoho-Vi5R6DZ7esnnjz_Q296UyA
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEF_qCdIXsX41WnUVQX3IkWQ3u4kgclZLK9SCtqVvYbO7OQ_O5LzcFfvfO7P5oJETxNfb34bLfGRnkpnfEPLShIFhigV-oTn3ubbCV2nOfGOl4pzHKnVdacdfxOEZ_3wRX2yRbmZrK8B6Y2qH86TOlvPxr59X78Hh37mpDTLsNo0XVWnHcF7Gkic3yM0IzkYs8jrm_XcF8G4h2ga6v-3cJreYZDJ17dXXzipH6d8_uEeLeVVvikr_LK68dlod3CG32zCTThq72CFbtrxLdlpHrunrlm36zT1yeYpzvaa0KuisvFRYzU5_WOwHRvVRVw7Z1MtRVRpqMGQEJNXtjIT5FZ3N59TxeNQUX-vS_ZPzo49-mL6lE-oKFvFP2iXFYbzLFXWMtvfJ2cGn0_1Dvx3G4GuRspUfxUmuRaxyloYF5DEB45bpBJTJ09Ak0iRhEXAbqcImgY4TzUxhIbiKIMMUOhLsARmVIOZdQhOZCuRlZ7lFNrEoT3mRSxnEuYELGOkRvxN7tmg4NzL34U1CrtLIL0ONZa3GPPIBddNjkTHb_VAtp1nrgBljMTepikJrwQiNSopCShFriVTdNtYeeYaazZr2097vs4mEHA47jCOPvHAIZM0osSxnqtZ1nR2dnP8D6NvXAehVCyoqsBGt2lYIuCdk4xog9wZI8H09WN5FO-ykUmdI5ybwJVYAOzvb3Lz8vF_Gi2KpXWmrtcNADCghjfDIw8aUe8l2juGRZGDkA9EPV8rZd0dajuPsBNjCo__f-phswz3jMBI_SvbIaLVc2ycQEq7yp87LfwPs_2AB
  priority: 102
  providerName: Scholars Portal
Title Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study
URI https://www.ncbi.nlm.nih.gov/pubmed/37379286
https://www.proquest.com/docview/2830601500
https://www.proquest.com/docview/2831297020
https://pubmed.ncbi.nlm.nih.gov/PMC10306211
https://doaj.org/article/3354d9a21eea44da8ff7765c75174e5c
http://dx.doi.org/10.1371/journal.pone.0285748
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe28sILYnwtMIpBSMBD2iR2bIe3rqxsSN2msU19ixLHKZXapOrHJP577pykWtAeEC-uVF-i5D7sO-fud4R8zHwvYwnz3Fxz7nJthJtEKXMzIxPOeZhEtiptfC5Ob_iPSTjZI6KphbFJ-zqd9Yr5olfMftncyuVC95s8sf7leIitsQRELv19sg_7bxOjV-svWLAQdZEck36_lklvWRamB7tpKDk26WOSyciWUN_bjyxs_25x7izn5fohz_PvBMp7O9LoKXlSu5J0UD3yAdkzxTNyUBvrmn6uEaW_PCd319i7a0rLnM6KuwQz1unCYM0viojalMcqJ44mRUYzdAuBkuq6D8L8N53N59RidawpHt3S4cXt2TfXj77SAbVJifiQZkWx4e5qQy1q7QtyMzq5Hp66dcMFV4uIbdwgVKkWYZKyyM8hVvEYN0wrEBiP_EzJTPm5x02Q5EZ5OlSaZbkBByoAWQgdCPaSdApg8yGhSkYCsddZahAxLEgjnqdSemGawQ0y6RC3YXu8rHA1YvtxTUI8UvEvRonFtcQccoyy2dEiKrb9o1xN41o3YsZCnkVJ4BsDipYlKs-lFKGWCMdtQu2QdyjZuCox3dl2PJAQp2EVceCQD5YCkTEKTL2ZJtv1Oj67uP0Hop9XLaJPNVFego7opC53gHdCxK0W5VGLEuxbt6YPUQ8brqxjhGwTeFDlwZWNbj48_X43jTfFdLrClFtLA36ehFDBIa8qVd5xtjEMh6iWkrdY354BO7XA5I1dvv7_S9-Qx_DO2HDEDdQR6WxWW_MW3L5N2gVbn0gY1dDHcfS9Sx4dn5xfXsGvVfquPVCBccxV164JfwD9g12B
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,12223,12765,21388,24318,27924,27925,31719,31720,33266,33267,33373,33374,33744,33745,38516,43310,43579,43600,43805,43895,53791,53793,73745,74014,74035,74302,74412
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELege4CXifG1wGAGIQEP2ZLYsRNeUDc2tbB1aHTT3iLHdkqlkpSmncR_j89xyoImxGt8iez7sO-cu98h9EaFgSKCBH4hKfWp1MwXaU58pbmglMYitVVppyM2uKCfr-Ird-FWu7TKdk-0G7WqJNyR7wNQFYPwPPg4_-lD1yj4u-paaNxFG4CcHvfQxsHR6Ot5uxcba2bMFcwRHu47-ezNq1LvmZM15tD358aBZHH717tzbz6r6ttcz78zKG8cSccP0KbzJXG_Ef4WuqPLh2jLWWuN3zlI6feP0PUYmndNcFXgaXktIGUd_9BQ9AsywjbnsUmKw6JUWIFfaCixdI0QZr_wdDbDFqyjxnB3iw_PLoef_DD9gPvYZiXCJPUCQ8fdxRJb2NrH6OL4aHw48F3HBV-ylCz9KE5yyWKRkzQsTLASEKqJTIzEaBqqhKskLAKqI1HoJJBxIokqtPGgIhNGMhkx8gT1SsPbbYQTnjIAXye5BsiwKE9pkXMexLkyH1DcQ37L9mzeAGtk9u8aNwFJw78MxJQ5MXnoAGSzpgVYbPugWkwyZ2UZITFVqYhCrY2mKZEUBecslhzwuHUsPbQLks2aGtO1cWd9bgI1KCOOPPTaUgA0Rgm5NxOxqutseHb5H0TfzjtEbx1RURkdkcLVO5g1AeRWh3KnQ2kMXHaGt0EPW67U2R9TMG-2unn78Kv1MHwU8ulKXa0sjXH0uIkVPPS0UeU1ZwknPI0S5qGko-Qd1ndHyul3i0wOPeuY0YVn_57XLro3GJ-eZCfD0Zfn6L5ZI3QY8aNkB_WWi5V-Yfy8Zf7SGfNvCWJQ0Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLagkxAvE-O2wGAGIQEPWZPYsRNeUHepVi7dNLZpb5FjO6VSSUrTTuLf4-M4ZUET4rU-jZJzsc9JvvMdhN6oMFBEkMAvJKU-lZr5Is2JrzQXlNJYpLYr7euYHV_QT1fxlcM_1Q5W2e6JdqNWlYR35H0gqmJQngf9wsEiTg-HH-c_fZggBV9a3TiNu2jDnIpB1EMb-0fj07N2XzaRzZhrniM87Dtb7c2rUu-ZUzbmMAPoxuFkOfzXO3VvPqvq29LQv9GUN46n4QO06fJKPGgcYQvd0eVDtOUit8bvHL30-0fo-hwGeU1wVeBpeS0Avo5_aGgABnthi39sAHJYlAoryBGNJJZuKMLsF57OZtgSd9QY3uPig5PL0aEfph_wAFuEItykXmCYvrtYYkth-xhdDI_OD459N33BlywlSz-Kk1yyWOQkDQtTuASEaiITYz2ahirhKgmLgOpIFDoJZJxIogptsqnIlJRMRow8Qb3S6HYb4YSnDIjYSa6BPizKU1rknAdxrswFFPeQ36o9mzckG5n90sZNcdLoLwMzZc5MHtoH26xlgSLb_lAtJpmLuIyQmKpURKHWxuuUSIqCcxZLDtzcOpYe2gXLZk2_6TrQswE3RRu0FEceem0lgCajBIebiFVdZ6OTy_8Q-nbWEXrrhIrK-IgUrvfBPBPQb3UkdzqSJthlZ3kb_LDVSp39CQvzz9Y3b19-tV6GiwK2rtTVysqYpI-busFDTxtXXmuWcMLTKGEeSjpO3lF9d6Wcfrcs5TC_jhlfePbv-9pF90wcZ19G48_P0X3ziDBsxI-SHdRbLlb6hUn5lvlLF8u_AfVoVP4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Timing+of+invasive+mechanical+ventilation+and+death+in+critically+ill+adults+with+COVID-19%3A+A+multicenter+cohort+study&rft.jtitle=PloS+one&rft.au=Green%2C+Adam&rft.au=Rachoin%2C+Jean-Sebastien&rft.au=Schorr%2C+Christa&rft.au=Dellinger%2C+Phil&rft.date=2023-06-28&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=18&rft.issue=6&rft_id=info:doi/10.1371%2Fjournal.pone.0285748&rft_id=info%3Apmid%2F37379286&rft.externalDBID=PMC10306211
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon