Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI

• Published in: NeuroImage clinical Vol. 25; p. 102182
• Main Authors: Broadhouse, Kathryn M., Singh, Maria Fiatarone, Suo, Chao, Gates, Nicola, Wen, Wei, Brodaty, Henry, Jain, Nidhi, Wilson, Guy C., Meiklejohn, Jacinda, Singh, Nalin, Baune, Bernhard T., Baker, Michael, Foroughi, Nasim, Wang, Yi, Kochan, Nicole, Ashton, Kevin, Brown, Matt, Li, Zhixiu, Mavros, Yorgi, Sachdev, Perminder S., Valenzuela, Michael J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2020; Elsevier
• Subjects: Aged; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - rehabilitation; Cognitive Remediation; Combined Modality Therapy; Connectome; Female; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - pathology; Hippocampus - physiopathology; Humans; Longitudinal Studies; Male; Middle Aged; Mild cognitive impairment; Nerve Net - diagnostic imaging; Nerve Net - pathology; Nerve Net - physiopathology; Neuronal Plasticity - physiology; Outcome Assessment, Health Care; Placebos; Plasticity; Radiology; Randomised controlled trial; Regular; Resistance exercise; Resistance Training; Subfields; Subfields; Mild cognitive impairment; Hippocampus; Resistance exercise; Plasticity; Randomised controlled trial

•Progressive resistance exercise leads to long-term cognitive benefits in MCI.•Resistance exercise slows post-training CA1, subiculum and dentate atrophy.•Within-training preservation of PCC predicts long-term hippocampal preservation.•Neuroprotection of AD-vulnerable hippocampal subfields mediate l...