Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis

• Published in: PloS one Vol. 18; no. 7; p. e0286525
• Main Authors: Leitner, Brooks P., Lee, Won D., Zhu, Wanling, Zhang, Xinyi, Gaspar, Rafael C., Li, Zongyu, Rabinowitz, Joshua D., Perry, Rachel J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.07.2023; Public Library of Science (PLoS)
• Subjects: Amino acids; Analysis; Antioxidants; Biology and Life Sciences; Biopsy; Biosynthesis; Care and treatment; Chain branching; Clinical trials; Correlation; Cytokines; Diagnosis; Electron transport; Fatty acids; Gene expression; Glutamine; Glutathione; Health aspects; Infection; Inflammation; Intensive care; Kidneys; Liver; Mass spectrometry; Medicine and Health Sciences; Metabolic response; Metabolism; Metabolites; Metabolomics; Mitochondria; Morbidity; Mortality; Muscles; Musculoskeletal system; Organs; Oxidation; Oxidative stress; Patients; Phenotyping; Physical Sciences; Physiological aspects; Plasma; Quadriceps muscle; Scientific imaging; Sepsis; Skeletal muscle; Spleen; Tissues; Transcriptomics; Tricarboxylic acid cycle; United States

Reprogramming metabolism is of great therapeutic interest for reducing morbidity and mortality during sepsis-induced critical illness. Disappointing results from randomized controlled trials targeting glutamine and antioxidant metabolism in patients with sepsis have begged a deeper understanding of...