Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania

• Published in: PloS one Vol. 14; no. 4; p. e0206334
• Main Authors: Rutaihwa, Liliana K, Sasamalo, Mohamed, Jaleco, Aladino, Hella, Jerry, Kingazi, Ally, Kamwela, Lujeko, Kingalu, Amri, Malewo, Bryceson, Shirima, Raymond, Doetsch, Anna, Feldmann, Julia, Reinhard, Miriam, Borrell, Sonia, Brites, Daniela, Reither, Klaus, Doulla, Basra, Fenner, Lukas, Gagneux, Sebastien
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.04.2019; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Biodiversity; Biology and Life Sciences; Chromosomes; Clinical isolates; Computer and Information Sciences; Confidence intervals; Distribution; Drug resistance; Earth Sciences; Ecology and Environmental Sciences; Environmental factors; Epidemics; Epidemiology; Female; Gender differences; Genetic aspects; Genetic diversity; Genetic polymorphisms; Genotyping; Health aspects; Health care; HIV; HIV patients; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Laboratories; Leprosy; Male; Medicine and Health Sciences; Middle Aged; Multidrug resistance; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Novels; People and Places; Phenotypes; Phylogeny; Polymorphism, Single Nucleotide; Population studies; Prevalence studies (Epidemiology); Public health; Research and Analysis Methods; Sex ratio; Sexually transmitted diseases; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Spacer; STD; Studies; Tanzania - epidemiology; Tuberculosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - genetics; Tuberculosis, Pulmonary - microbiology; Tanzania; Beijing China; Switzerland; China; Africa

Human tuberculosis (TB) is caused by seven phylogenetic lineages of the Mycobacterium tuberculosis complex (MTBC), Lineage 1-7. Recent advances in rapid genotyping of MTBC based on single nucleotide polymorphisms (SNP), allow for phylogenetically robust strain classification, paving the way for defi...