Progesterone Treatment Shows Benefit in Female Rats in a Pediatric Model of Controlled Cortical Impact Injury

• Published in: PloS one Vol. 11; no. 1; p. e0146419
• Main Authors: Geddes, Rastafa I., Peterson, Bethany L., Stein, Donald G., Sayeed, Iqbal
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.01.2016; Public Library of Science (PLoS)
• Subjects: Animal behavior; Animals; Attention; Behavior, Animal - drug effects; Biology and Life Sciences; Body weight; Brain; Brain injuries; Brain Injuries - drug therapy; Brain injury; Care and treatment; Cortex (frontal); Development and progression; Disease Models, Animal; Dose-Response Relationship, Drug; Emergency medical care; Female; Females; Fuel consumption; Gender; Gender aspects; Gender differences; Head injuries; Injury prevention; Lesions; Male; Maze Learning - drug effects; Medicine and Health Sciences; Neuroprotective Agents - therapeutic use; Prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - injuries; Prefrontal Cortex - pathology; Progesterone; Progesterone - therapeutic use; Progestins - therapeutic use; Rats; Rats, Sprague-Dawley; Research and Analysis Methods; Risk factors; Rodents; Sex differences; Sex Factors; Traumatic brain injury; United States; Atlanta Georgia; United States > US

We recently showed that progesterone treatment can reduce lesion size and behavioral deficits after moderate-to-severe bilateral injury to the medial prefrontal cortex in immature male rats. Whether there are important sex differences in response to injury and progesterone treatment in very young su...