EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2

• Published in: PloS one Vol. 15; no. 11; p. e0241739
• Main Authors: Roshdy, Wael H., Rashed, Helmy A., Kandeil, Ahmed, Mostafa, Ahmed, Moatasim, Yassmin, Kutkat, Omnia, Abo Shama, Noura M., Gomaa, Mokhtar R., El-Sayed, Ibrahim H., El Guindy, Nancy M., Naguib, Amal, Kayali, Ghazi, Ali, Mohamed A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.11.2020; Public Library of Science (PLoS)
• Subjects: Active Transport, Cell Nucleus - drug effects; Animals; Antiviral activity; Antiviral agents; Antiviral Agents - pharmacology; Antiviral drugs; Bioavailability; Biology and life sciences; Care and treatment; Cell lines; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Chlorocebus aethiops; Coronaviruses; COVID-19; Curcuma - chemistry; Curcumin; Cytokine storm; Cytokines; Disease; Funding; Health aspects; Herbal medicine; Humans; Immune response; Immunologic Factors - pharmacology; Immunomodulation; Immunomodulators; Infections; Influenza; Interleukin 6; Interleukin-6 - metabolism; Kinetics; Laboratories; Mass spectrometry; Medicine and health sciences; Mitochondrial DNA; NF-kappa B p50 Subunit - metabolism; NF-KappaB Inhibitor alpha - metabolism; Nuclear transport; Pandemics; Pathogenesis; Physical Sciences; Piper nigrum; Piper nigrum - chemistry; Plant extracts; Plant Extracts - pharmacology; Population; Public health; Research and Analysis Methods; Respiratory diseases; SARS-CoV-2 - drug effects; Scientific imaging; Seeds; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Supervision; Testing; Translocation; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Vaccines; Vero Cells; Viral diseases; Viral infections; Viruses; Egypt; Cairo Egypt; United States > US; Giza Egypt

Due to the challenges for developing vaccines in devastating pandemic situations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developing and screening of novel antiviral agents are peremptorily demanded. Herein, we developed EGYVIR as a potent immunomodulatory herbal extract with...