Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes

• Published in: PloS one Vol. 11; no. 2; p. e0147981
• Main Authors: Li, Hung-Yuan, Lin, Hung-An, Nien, Feng-Jung, Wu, Vin-Cent, Jiang, Yi-Der, Chang, Tien-Jyun, Kao, Hsien-Li, Lin, Mao-Shin, Wei, Jung-Nan, Lin, Cheng-Hsin, Shih, Shyang-Rong, Hung, Chi-Sheng, Chuang, Lee-Ming
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.02.2016; Public Library of Science (PLoS)
• Subjects: Adhesion; Aged; Aldehydes; Amine Oxidase (Copper-Containing) - blood; Amines; Ammonia; Ankle; Atherosclerosis; Biology and Life Sciences; Biomarkers; Body mass; Body mass index; Body size; Cardiovascular diseases; Cell adhesion molecules; Cell Adhesion Molecules - blood; Cholesterol; Chronic illnesses; Chronic kidney failure; Clinical medicine; Comorbidity; Complications; Deamination; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - mortality; Diabetic retinopathy; Diagnosis; End-stage renal disease; Female; Fibroblasts; Follow-Up Studies; Genetic aspects; Glucose; Health aspects; Health care; Hemoglobin; Hospitals; Humans; Hydrogen; Hydrogen peroxide; Hypertension; Internal medicine; Kaplan-Meier Estimate; Kidney diseases; Kidney Failure, Chronic - diagnosis; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - mortality; Male; Medicine and Health Sciences; Metabolism; Middle Aged; Mortality; Nephrology; Pathogenesis; Patients; Physiological aspects; Preventive medicine; Prognosis; Proportional Hazards Models; Prospective Studies; Proteins; Proteinuria; Risk; Risk Factors; Smoking; Statins; Taiwan - epidemiology; Type 2 diabetes; Taiwan; Japan

Diabetes is the leading cause of end-stage renal disease (ESRD) worldwide. Vascular adhesion protein-1 (VAP-1) participates in inflammation and catalyzes the deamination of primary amines into aldehydes, hydrogen peroxide, and ammonia, both of which are involved in the pathogenesis of diabetic compl...