Genetic Variants in Caveolin-1 and RhoA/ROCK1 Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population

• Published in: PloS one Vol. 10; no. 6; p. e0128771
• Main Authors: Zhao, Ruizhe, Liu, Kang, Huang, Zhengkai, Wang, Jun, Pan, Yongsheng, Huang, Yuan, Deng, Xiaheng, Liu, Jinliang, Qin, Chao, Cheng, Gong, Hua, Lixin, Li, Jie, Yin, Changjun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.06.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Alleles; Angiogenesis; Asian Continental Ancestry Group; Breast cancer; Cancer; Cancer research; Carcinoma, Renal Cell - epidemiology; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - metabolism; Caveolin; Caveolin 1 - genetics; Caveolin 1 - metabolism; Caveolin-1; China; Clear cell-type renal cell carcinoma; Development and progression; Diabetes; Diabetes mellitus; Female; Gene polymorphism; Genetic diversity; Genetic variance; Genotypes; Hospitals; Humans; Hypertension; Kidney cancer; Kidney Neoplasms - epidemiology; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kinases; Laboratories; Male; Medical research; Medicine; Metastasis; Middle Aged; Molecular biology; Motility; mRNA; Patients; Polymorphism; Polymorphism, Single Nucleotide; Population; Proteins; Renal cell carcinoma; Reproductive health; Rho-associated kinase; rho-Associated Kinases - genetics; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - genetics; rhoA GTP-Binding Protein - metabolism; RhoA protein; Risk analysis; Risk Factors; RNA; Rocks; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Tumorigenesis; Urology; China

The RhoA/ROCK pathway and Caveolin-1 (Cav-1) participate in the process of tumorigenesis in numerous types of cancer. Up-regulation of RhoA/ROCK and Cav-1 expression is considered to be associated with the development and progression of clear cell renal cell carcinoma (ccRCC). We investigated the as...