Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia

Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann’s Area 46) is implicated in schizophrenia and executes high functions such as...

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Published inJournal of psychiatric research Vol. 43; no. 11; pp. 978 - 986
Main Authors Martins-de-Souza, Daniel, Gattaz, Wagner F., Schmitt, Andrea, Maccarrone, Giuseppina, Hunyadi-Gulyás, Eva, Eberlin, Marcos N., Souza, Gustavo H.M.F., Marangoni, Sérgio, Novello, José C., Turck, Christoph W., Dias-Neto, Emmanuel
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.07.2009
Elsevier
Subjects
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers - metabolism
Cortex
Cytoskeleton
Cytoskeleton - metabolism
Dorsolateral prefrontal cortex
Electrophoresis, Gel, Two-Dimensional - methods
Energy Metabolism - physiology
Female
Gene Expression Regulation
Humans
Male
Medical sciences
Metabolism
Middle Aged
Mitochondria
Myelinization
Oligodendroglia - metabolism
Peptide Mapping - methods
Prefrontal Cortex - metabolism
Proteins
Proteomics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - pathology
Schizophrenia - physiopathology
Spectrometry
Tandem Mass Spectrometry - methods
Dorsolateral prefrontal cortex
Schizophrenia
Cytoskeleton
Mitochondria
Proteomics
Myelinization
Psychosis
Energy metabolism
Oligodendrocyte
Neuroglia
Central nervous system
Encephalon
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Abstract Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann’s Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients’ dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease.
AbstractList Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann's Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients' dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease.
Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann's Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients' dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease. [Copyright Elsevier Ltd.]
Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann's Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients' dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease.Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann's Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients' dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease.
Abstract Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann’s Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients’ dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease.
Author Souza, Gustavo H.M.F.
Maccarrone, Giuseppina
Marangoni, Sérgio
Hunyadi-Gulyás, Eva
Gattaz, Wagner F.
Eberlin, Marcos N.
Novello, José C.
Martins-de-Souza, Daniel
Turck, Christoph W.
Dias-Neto, Emmanuel
Schmitt, Andrea
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  surname: Martins-de-Souza
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  email: martins@mpipsykl.mpg.de
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– sequence: 2
  givenname: Wagner F.
  surname: Gattaz
  fullname: Gattaz, Wagner F.
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  fullname: Maccarrone, Giuseppina
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  givenname: Eva
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  fullname: Hunyadi-Gulyás, Eva
  organization: Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, D 80804, Munich, Germany
– sequence: 6
  givenname: Marcos N.
  surname: Eberlin
  fullname: Eberlin, Marcos N.
  organization: Thomson Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas, UNICAMP, Campinas, SP 13083-970, Brazil
– sequence: 7
  givenname: Gustavo H.M.F.
  surname: Souza
  fullname: Souza, Gustavo H.M.F.
  organization: Thomson Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas, UNICAMP, Campinas, SP 13083-970, Brazil
– sequence: 8
  givenname: Sérgio
  surname: Marangoni
  fullname: Marangoni, Sérgio
  organization: Laboratório de Proteômica, Departamento de Bioquímica, Instituto de Biologia, UNICAMP, CEP 13083-970, Campinas, SP, Brazil
– sequence: 9
  givenname: José C.
  surname: Novello
  fullname: Novello, José C.
  organization: Laboratório de Proteômica, Departamento de Bioquímica, Instituto de Biologia, UNICAMP, CEP 13083-970, Campinas, SP, Brazil
– sequence: 10
  givenname: Christoph W.
  surname: Turck
  fullname: Turck, Christoph W.
  organization: Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, D 80804, Munich, Germany
– sequence: 11
  givenname: Emmanuel
  surname: Dias-Neto
  fullname: Dias-Neto, Emmanuel
  email: emmanuel@usp.br
  organization: Laboratório de Neurociências, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr. Ovídio Pires de Campos, 785 Consolação, São Paulo, SP, CEP 05403-010, Brazil
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Issue 11
Keywords Dorsolateral prefrontal cortex
Schizophrenia
Cytoskeleton
Mitochondria
Proteomics
Myelinization
Psychosis
Energy metabolism
Oligodendrocyte
Neuroglia
Central nervous system
Encephalon
Language English
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Snippet Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the...
Abstract Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the...
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SubjectTerms Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers - metabolism
Cortex
Cytoskeleton
Cytoskeleton - metabolism
Dorsolateral prefrontal cortex
Electrophoresis, Gel, Two-Dimensional - methods
Energy Metabolism - physiology
Female
Gene Expression Regulation
Humans
Male
Medical sciences
Metabolism
Middle Aged
Mitochondria
Myelinization
Oligodendroglia - metabolism
Peptide Mapping - methods
Prefrontal Cortex - metabolism
Proteins
Proteomics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - pathology
Schizophrenia - physiopathology
Spectrometry
Tandem Mass Spectrometry - methods
Title Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia
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https://dx.doi.org/10.1016/j.jpsychires.2008.11.006
https://www.ncbi.nlm.nih.gov/pubmed/19110265
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Volume 43
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