A flexible mathematical model platform for studying branching networks: experimentally validated using the model actinomycete, Streptomyces coelicolor

• Published in: PloS one Vol. 8; no. 2; p. e54316
• Main Authors: Nieminen, Leena, Webb, Steven, Smith, Margaret C M, Hoskisson, Paul A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2013; Public Library of Science (PLoS)
• Subjects: Algorithms; Angiogenesis; Antibiotics; Biology; Cell division; Computer Simulation; Cues; Environment; Fermentation; Hyphae; Liquid culture; Mathematical analysis; Mathematical models; Mathematics; Medicine; Metabolism; Metabolites; Microorganisms; Microscopy; Models, Molecular; Morphology; Networks; Ordinary differential equations; Oxygen Consumption; Pharmacy; Reproducibility of Results; Soil dynamics; Soil microorganisms; Streptomyces; Streptomyces coelicolor; Streptomyces coelicolor - growth & development; Streptomyces coelicolor - physiology; Studies; Tips; Velocity

Branching networks are ubiquitous in nature and their growth often responds to environmental cues dynamically. Using the antibiotic-producing soil bacterium Streptomyces as a model we have developed a flexible mathematical model platform for the study of branched biological networks. Streptomyces fo...