Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis
Small wear particles (0.1-10 μm) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and osteolysis. However, little is known about the roles of larger wear particles (10-100 μm) in periprosthetic inflammation and osteolysis. Additi...
Saved in:
Published in | PloS one Vol. 13; no. 8; p. e0202501 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
20.08.2018
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Small wear particles (0.1-10 μm) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and osteolysis. However, little is known about the roles of larger wear particles (10-100 μm) in periprosthetic inflammation and osteolysis. Additionally, although ample studies demonstrated that increased oxidative stress is critically involved in particle-induced inflammation and osteolysis, detailed changes in antioxidant enzymes expression in the disease development remain largely unclear. Herein, we used a rat knee prosthesis model to assess effects of polyethylene (PE) particles (20-60 μm) on the levels of oxidative stress markers such as malondialdehyde (MDA) and total antioxidant capacity (TAC) in blood plasma, and on the expression profiles of antioxidant enzymes in knee joint tissues. In combination with a forced-exercise intervention for all surgical rats, we found that the rat groups treated with both artificial joint and PE particles exhibited higher MDA levels and lower TAC levels, together with lower levels of physical activity and higher levels of inflammatory markers, than the sham group and the groups receiving artificial joint or PE particles alone at weeks 20-24 post-operatively. Dose-response relationships between the exposure to PE particles and the induction of oxidative stress and inflammation were also observed in the artificial joint/PE groups. Under such conditions, we unexpectedly found that most of antioxidant enzymes displayed pronounced up-regulation, with concomitant induction of inflammatory and osteoclast-inducing factors (including IL-1β, NF-κB and RANKL), in the artificial joint/PE groups as compared to the sham, artificial joint only, or PE only group. Only a few antioxidant enzymes including SOD2 and GPx2 showed down-regulation. Collectively, our findings demonstrate that implantation of artificial joint along with large PE particles synergistically trigger the induction of oxidative stress; however, down-regulation of many antioxidant enzymes may not necessarily occur during the disease development. |
---|---|
AbstractList | Small wear particles (0.1-10 μm) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and osteolysis. However, little is known about the roles of larger wear particles (10-100 μm) in periprosthetic inflammation and osteolysis. Additionally, although ample studies demonstrated that increased oxidative stress is critically involved in particle-induced inflammation and osteolysis, detailed changes in antioxidant enzymes expression in the disease development remain largely unclear. Herein, we used a rat knee prosthesis model to assess effects of polyethylene (PE) particles (20-60 μm) on the levels of oxidative stress markers such as malondialdehyde (MDA) and total antioxidant capacity (TAC) in blood plasma, and on the expression profiles of antioxidant enzymes in knee joint tissues. In combination with a forced-exercise intervention for all surgical rats, we found that the rat groups treated with both artificial joint and PE particles exhibited higher MDA levels and lower TAC levels, together with lower levels of physical activity and higher levels of inflammatory markers, than the sham group and the groups receiving artificial joint or PE particles alone at weeks 20-24 post-operatively. Dose-response relationships between the exposure to PE particles and the induction of oxidative stress and inflammation were also observed in the artificial joint/PE groups. Under such conditions, we unexpectedly found that most of antioxidant enzymes displayed pronounced up-regulation, with concomitant induction of inflammatory and osteoclast-inducing factors (including IL-1β, NF-κB and RANKL), in the artificial joint/PE groups as compared to the sham, artificial joint only, or PE only group. Only a few antioxidant enzymes including SOD2 and GPx2 showed down-regulation. Collectively, our findings demonstrate that implantation of artificial joint along with large PE particles synergistically trigger the induction of oxidative stress; however, down-regulation of many antioxidant enzymes may not necessarily occur during the disease development. Small wear particles (0.1-10 [mu]m) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and osteolysis. However, little is known about the roles of larger wear particles (10-100 [mu]m) in periprosthetic inflammation and osteolysis. Additionally, although ample studies demonstrated that increased oxidative stress is critically involved in particle-induced inflammation and osteolysis, detailed changes in antioxidant enzymes expression in the disease development remain largely unclear. Herein, we used a rat knee prosthesis model to assess effects of polyethylene (PE) particles (20-60 [mu]m) on the levels of oxidative stress markers such as malondialdehyde (MDA) and total antioxidant capacity (TAC) in blood plasma, and on the expression profiles of antioxidant enzymes in knee joint tissues. In combination with a forced-exercise intervention for all surgical rats, we found that the rat groups treated with both artificial joint and PE particles exhibited higher MDA levels and lower TAC levels, together with lower levels of physical activity and higher levels of inflammatory markers, than the sham group and the groups receiving artificial joint or PE particles alone at weeks 20-24 post-operatively. Dose-response relationships between the exposure to PE particles and the induction of oxidative stress and inflammation were also observed in the artificial joint/PE groups. Under such conditions, we unexpectedly found that most of antioxidant enzymes displayed pronounced up-regulation, with concomitant induction of inflammatory and osteoclast-inducing factors (including IL-1[beta], NF-[kappa]B and RANKL), in the artificial joint/PE groups as compared to the sham, artificial joint only, or PE only group. Only a few antioxidant enzymes including SOD2 and GPx2 showed down-regulation. Collectively, our findings demonstrate that implantation of artificial joint along with large PE particles synergistically trigger the induction of oxidative stress; however, down-regulation of many antioxidant enzymes may not necessarily occur during the disease development. |
Audience | Academic |
Author | Peng, Kuo-Ti Chen, Pei-Chun Lee, Chiang-Wen Chang, Pey-Jium Chang, Chih-Hsiang Tsai, Meng-Hsueh Chiang, Yao-Chang Shih, Hsin-Nung Chen, Chun-Chieh |
AuthorAffiliation | 3 Division of Basic Medical Sciences, Department of Nursing, and Chronic Diseases and Health Promotion Research Center, Chang Gung Institute of Technology, Chiayi, Taiwan 1 Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan 6 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan 2 College of Medicine, Chang-Gung University, Taoyuan, Taiwan 4 Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan 5 Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan Alexandria University, EGYPT 7 Department of Nephrology, Chang-Gung Memorial Hospital, Chiayi, Taiwan |
AuthorAffiliation_xml | – name: 5 Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan – name: Alexandria University, EGYPT – name: 6 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan – name: 3 Division of Basic Medical Sciences, Department of Nursing, and Chronic Diseases and Health Promotion Research Center, Chang Gung Institute of Technology, Chiayi, Taiwan – name: 1 Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan – name: 2 College of Medicine, Chang-Gung University, Taoyuan, Taiwan – name: 4 Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan – name: 7 Department of Nephrology, Chang-Gung Memorial Hospital, Chiayi, Taiwan |
Author_xml | – sequence: 1 givenname: Kuo-Ti surname: Peng fullname: Peng, Kuo-Ti organization: College of Medicine, Chang-Gung University, Taoyuan, Taiwan – sequence: 2 givenname: Meng-Hsueh surname: Tsai fullname: Tsai, Meng-Hsueh organization: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan – sequence: 3 givenname: Chiang-Wen surname: Lee fullname: Lee, Chiang-Wen organization: Division of Basic Medical Sciences, Department of Nursing, and Chronic Diseases and Health Promotion Research Center, Chang Gung Institute of Technology, Chiayi, Taiwan – sequence: 4 givenname: Yao-Chang surname: Chiang fullname: Chiang, Yao-Chang organization: Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan – sequence: 5 givenname: Pei-Chun surname: Chen fullname: Chen, Pei-Chun organization: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan – sequence: 6 givenname: Chun-Chieh surname: Chen fullname: Chen, Chun-Chieh organization: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan – sequence: 7 givenname: Chih-Hsiang surname: Chang fullname: Chang, Chih-Hsiang organization: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan – sequence: 8 givenname: Hsin-Nung surname: Shih fullname: Shih, Hsin-Nung organization: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan – sequence: 9 givenname: Pey-Jium orcidid: 0000-0002-6492-0346 surname: Chang fullname: Chang, Pey-Jium organization: Department of Nephrology, Chang-Gung Memorial Hospital, Chiayi, Taiwan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30125327$$D View this record in MEDLINE/PubMed |
BookMark | eNqNk0tr3DAQx01JaR7tNyitoVDaw271WMv2pRDS10Ig0NdVzMqjXQVZciy77ObTV846YV1yKDpIzPzmL81o5jQ5ct5hkrykZE55Tj9c-751YOdNNM8JIywj9ElyQkvOZoIRfnRwPk5OQ7gmJOOFEM-SY04oyzjLT5LbT7vQ4rq30GGV4rZpMQTjXep1Cq4zfmuquKfobnc1htS4tPF2h91mZ9Fh2kDbGWVxZlzVqyjRYGua1odug9EReW2hrqEbNMFVafRgFAgmPE-earABX4z7WfLry-efF99ml1dflxfnlzMlStbNdKEzXi4UAQ2FygSDhcpXlV6xckUUQIWkKJQQUIEo6EowDYwzThagsdQs52fJ671uY32QY9mCZKQkLM9FMRDLPVF5uJZNa2pod9KDkXcG367lmKakDFCrohIi1wutebESNM8EyRXQEkFFrY_jbf2qxkqh61qwE9Gpx5mNXPs_UlBCeZlFgXejQOtvegydrE1QaC049P3duynjsQOGd7_5B308u5FaQ0wgfoiP96pBVJ5nGSk5zQWL1PwRKq4Ka6Nij2kT7ZOA95OAyHS47dbQhyCXP77_P3v1e8q-PWA3CLbbBG_7oYPCFFzsQRXbLTaxfigyJXIYkftqyGFE5DgiMezV4Qc9BN3PBP8L8fkSKA |
CitedBy_id | crossref_primary_10_3389_fmolb_2019_00091 crossref_primary_10_3390_ijms23158331 crossref_primary_10_1016_j_biopha_2023_114834 crossref_primary_10_1038_s41420_023_01761_y crossref_primary_10_1007_s10616_023_00569_z crossref_primary_10_1016_j_arth_2024_01_062 crossref_primary_10_1002_jbm_b_34546 crossref_primary_10_3389_fendo_2021_638261 crossref_primary_10_1007_s12018_021_09278_7 crossref_primary_10_1016_j_cellsig_2022_110353 |
Cites_doi | 10.1182/blood-2004-09-3662 10.1007/s11420-006-9003-6 10.1177/0022034510363243 10.1159/000373996 10.1177/112070000301302s05 10.1016/S0300-483X(00)00306-1 10.1089/ars.2013.5305 10.3390/ma7020980 10.1023/A:1008901302646 10.1146/annurev-pathol-012513-104651 10.1016/S0142-9612(00)00089-2 10.1098/rsif.2013.0962 10.1002/1097-4636(200009)53:5<490::AID-JBM7>3.0.CO;2-7 10.1302/0301-620X.93B9.26736 10.1111/j.1600-0714.2009.00862.x 10.3390/ma8095269 10.1084/jem.20151116 10.1302/0301-620X.83B1.10871 10.1016/S0142-9612(98)00140-9 10.1054/arth.2002.30416 10.1016/j.biomaterials.2013.07.030 10.1016/j.yexcr.2004.07.035 10.1007/s10753-016-0306-6 10.1080/000164700317413067 10.1172/JCI114485 10.1302/0301-620X.93B4.25868 10.1002/jor.20013 10.1016/j.biomaterials.2003.10.054 10.5312/wjo.v2.i10.93 10.1016/j.biomaterials.2013.01.085 10.1080/00016470216314 10.1186/s12891-016-1131-7 10.1080/17453670610045902 10.1074/jbc.M109.051557 10.1016/j.actbio.2010.04.010 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2018 Public Library of Science 2018 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 Peng et al 2018 Peng et al |
Copyright_xml | – notice: COPYRIGHT 2018 Public Library of Science – notice: 2018 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2018 Peng et al 2018 Peng et al |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PIMPY PQEST PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
DOI | 10.1371/journal.pone.0202501 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Opposing Viewpoints Resource Center Science in Context ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing and Allied Health Journals Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic Technology Collection Technology Research Database Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic Agricultural Science Database |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) |
DocumentTitleAlternate | Antioxidant protein expression and particle-induced inflammation and osteolysis |
EISSN | 1932-6203 |
Editor | Sheweita, Salah A |
Editor_xml | – sequence: 1 givenname: Salah A surname: Sheweita fullname: Sheweita, Salah A |
EndPage | e0202501 |
ExternalDocumentID | 2090277687 oai_doaj_org_article_12aefc8d667f4ff38b6175607ca19eac A550931762 10_1371_journal_pone_0202501 30125327 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | United States--US Taiwan |
GeographicLocations_xml | – name: Taiwan – name: United States--US |
GrantInformation_xml | – fundername: ; grantid: NMRPG6F0111 – fundername: ; grantid: NMRPG3C6052 – fundername: ; grantid: CMRPG6F0341 – fundername: ; grantid: CMRPG3C1251 – fundername: ; grantid: CMRPG3C1252 – fundername: ; grantid: NMRPG3C6051 |
GroupedDBID | --- 123 29O 2WC 3V. 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV ADRAZ AEAQA AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CGR CS3 CUY CVF D1I D1J D1K DIK DU5 E3Z EAP EAS EBD ECM EIF EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ NPM O5R O5S OK1 P2P P62 PATMY PDBOC PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RIG RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX AFPKN CITATION 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PQEST PQUKI RC3 7X8 5PM AAPBV ABPTK N95 |
ID | FETCH-LOGICAL-c692t-f8f5394c0afa8c562a4c7bdfb29b0caade088c66ada681b62fa232304afe9f273 |
IEDL.DBID | RPM |
ISSN | 1932-6203 |
IngestDate | Sun Jul 02 11:03:53 EDT 2023 Tue Oct 22 15:10:30 EDT 2024 Tue Sep 17 21:21:30 EDT 2024 Fri Jun 28 15:16:33 EDT 2024 Thu Oct 10 19:21:26 EDT 2024 Fri Feb 23 00:04:32 EST 2024 Fri Feb 02 04:00:41 EST 2024 Thu Aug 01 20:04:52 EDT 2024 Thu Aug 01 20:06:57 EDT 2024 Tue Aug 20 22:07:12 EDT 2024 Fri Aug 23 03:29:11 EDT 2024 Wed Oct 16 00:50:27 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Language | English |
License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c692t-f8f5394c0afa8c562a4c7bdfb29b0caade088c66ada681b62fa232304afe9f273 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
ORCID | 0000-0002-6492-0346 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101395/ |
PMID | 30125327 |
PQID | 2090277687 |
PQPubID | 1436336 |
PageCount | e0202501 |
ParticipantIDs | plos_journals_2090277687 doaj_primary_oai_doaj_org_article_12aefc8d667f4ff38b6175607ca19eac pubmedcentral_primary_oai_pubmedcentral_nih_gov_6101395 proquest_miscellaneous_2091233717 proquest_journals_2090277687 gale_infotracmisc_A550931762 gale_infotracacademiconefile_A550931762 gale_incontextgauss_ISR_A550931762 gale_incontextgauss_IOV_A550931762 gale_healthsolutions_A550931762 crossref_primary_10_1371_journal_pone_0202501 pubmed_primary_30125327 |
PublicationCentury | 2000 |
PublicationDate | 2018-08-20 |
PublicationDateYYYYMMDD | 2018-08-20 |
PublicationDate_xml | – month: 08 year: 2018 text: 2018-08-20 day: 20 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
PublicationTitle | PloS one |
PublicationTitleAlternate | PLoS One |
PublicationYear | 2018 |
Publisher | Public Library of Science Public Library of Science (PLoS) |
Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
References | VK Raghunathan (ref12) 2013; 34 ML Wang (ref10) 2002; 17 M Yamada (ref13) 2010; 89 TR Green (ref22) 1998; 19 P Kinov (ref11) 2006; 24 A Lubbeke (ref3) 2011; 93 KT Peng (ref29) 2016; 17 LC Shen (ref28) 2010; 39 PE Purdue (ref6) 2006; 2 M Krajewska (ref27) 1996; 149 D Candas (ref37) 2014; 20 E Zolotarevova (ref33) 2010; 6 JB Matthews (ref25) 2000; 21 MJ Nine (ref30) 2014; 7 KT Peng (ref21) 2011; 93 SB Goodman (ref7) 2014; 11 W Chen (ref8) 2015; 35 H Ha (ref15) 2004; 301 M Sundfeldt (ref4) 2006; 77 P Herberts (ref1) 2000; 71 JM Mates (ref19) 2000; 153 JH Ingram (ref24) 2004; 25 JL Tipper (ref31) 2000; 11 O Robertsson (ref2) 2001; 83 G Luo (ref9) 2016; 39 M Sundfeldt (ref36) 2002; 73 NK Lee (ref16) 2005; 106 R Tsaryk (ref14) 2013; 34 IR Garrett (ref20) 1990; 85 E Ingham (ref32) 2003; 13 MS Kim (ref17) 2010; 285 GJ Atkins (ref5) 2011; 2 TR Green (ref23) 2000; 53 Z Sheikh (ref34) 2015; 8 JD Lambeth (ref18) 2014; 9 SM Jay (ref35) 2010; 93 R Rigoni (ref26) 2016; 213 |
References_xml | – volume: 106 start-page: 852 issue: 3 year: 2005 ident: ref16 article-title: A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation publication-title: Blood doi: 10.1182/blood-2004-09-3662 contributor: fullname: NK Lee – volume: 2 start-page: 102 issue: 2 year: 2006 ident: ref6 article-title: The central role of wear debris in periprosthetic osteolysis publication-title: HSS J doi: 10.1007/s11420-006-9003-6 contributor: fullname: PE Purdue – volume: 149 start-page: 1449 issue: 5 year: 1996 ident: ref27 article-title: Immunohistochemical analysis of Bcl-2 family proteins in adenocarcinomas of the stomach publication-title: Am J Pathol contributor: fullname: M Krajewska – volume: 89 start-page: 411 issue: 4 year: 2010 ident: ref13 article-title: N-acetyl cysteine alleviates cytotoxicity of bone substitute publication-title: J Dent Res doi: 10.1177/0022034510363243 contributor: fullname: M Yamada – volume: 35 start-page: 1857 issue: 5 year: 2015 ident: ref8 article-title: Wear particles promote reactive oxygen species-mediated inflammation via the nicotinamide adenine dinucleotide phosphate oxidase pathway in macrophages surrounding loosened implants publication-title: Cell Physiol Biochem doi: 10.1159/000373996 contributor: fullname: W Chen – volume: 13 start-page: 17 issue: 1 year: 2003 ident: ref32 article-title: Wear of historical polyethylenes in hip prostheses. Biomechanical success and a biological failure publication-title: Hip Int doi: 10.1177/112070000301302s05 contributor: fullname: E Ingham – volume: 153 start-page: 83 issue: 1–3 year: 2000 ident: ref19 article-title: Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology publication-title: Toxicology doi: 10.1016/S0300-483X(00)00306-1 contributor: fullname: JM Mates – volume: 20 start-page: 1599 issue: 10 year: 2014 ident: ref37 article-title: MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx publication-title: Antioxid Redox Signal doi: 10.1089/ars.2013.5305 contributor: fullname: D Candas – volume: 7 start-page: 980 issue: 2 year: 2014 ident: ref30 article-title: Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints publication-title: Materials (Basel) doi: 10.3390/ma7020980 contributor: fullname: MJ Nine – volume: 11 start-page: 117 issue: 2 year: 2000 ident: ref31 article-title: Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Charnley hip prostheses publication-title: J Mater Sci Mater Med doi: 10.1023/A:1008901302646 contributor: fullname: JL Tipper – volume: 9 start-page: 119 year: 2014 ident: ref18 article-title: Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited publication-title: Annu Rev Pathol doi: 10.1146/annurev-pathol-012513-104651 contributor: fullname: JD Lambeth – volume: 21 start-page: 2033 issue: 20 year: 2000 ident: ref25 article-title: Comparison of the response of primary human peripheral blood mononuclear phagocytes from different donors to challenge with model polyethylene particles of known size and dose publication-title: Biomaterials doi: 10.1016/S0142-9612(00)00089-2 contributor: fullname: JB Matthews – volume: 11 start-page: 20130962 issue: 93 year: 2014 ident: ref7 article-title: Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement publication-title: J R Soc Interface doi: 10.1098/rsif.2013.0962 contributor: fullname: SB Goodman – volume: 53 start-page: 490 issue: 5 year: 2000 ident: ref23 article-title: Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles publication-title: J Biomed Mater Res doi: 10.1002/1097-4636(200009)53:5<490::AID-JBM7>3.0.CO;2-7 contributor: fullname: TR Green – volume: 93 start-page: 1201 issue: 9 year: 2011 ident: ref21 article-title: The role of reactive oxygen species scavenging enzymes in the development of aseptic loosening after total hip replacement publication-title: J Bone Joint Surg Br doi: 10.1302/0301-620X.93B9.26736 contributor: fullname: KT Peng – volume: 39 start-page: 242 issue: 3 year: 2010 ident: ref28 article-title: Expression of osteonectin/secreted protein acidic and rich in cysteine and matrix metalloproteinases in ameloblastoma publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.2009.00862.x contributor: fullname: LC Shen – volume: 8 start-page: 5671 issue: 9 year: 2015 ident: ref34 article-title: Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials publication-title: Materials (Basel) doi: 10.3390/ma8095269 contributor: fullname: Z Sheikh – volume: 213 start-page: 355 issue: 3 year: 2016 ident: ref26 article-title: Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects publication-title: J Exp Med doi: 10.1084/jem.20151116 contributor: fullname: R Rigoni – volume: 93 start-page: 189 issue: 1 year: 2010 ident: ref35 article-title: Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models publication-title: J Biomed Mater Res A contributor: fullname: SM Jay – volume: 83 start-page: 45 issue: 1 year: 2001 ident: ref2 article-title: The routine of surgical management reduces failure after unicompartmental knee arthroplasty publication-title: J Bone Joint Surg Br doi: 10.1302/0301-620X.83B1.10871 contributor: fullname: O Robertsson – volume: 19 start-page: 2297 issue: 24 year: 1998 ident: ref22 article-title: Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro publication-title: Biomaterials doi: 10.1016/S0142-9612(98)00140-9 contributor: fullname: TR Green – volume: 17 start-page: 335 issue: 3 year: 2002 ident: ref10 article-title: Exposure to particles stimulates superoxide production by human THP-1 macrophages and avian HD-11EM osteoclasts activated by tumor necrosis factor-alpha and PMA publication-title: J Arthroplasty doi: 10.1054/arth.2002.30416 contributor: fullname: ML Wang – volume: 34 start-page: 8075 issue: 33 year: 2013 ident: ref14 article-title: The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6Al4V alloy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.07.030 contributor: fullname: R Tsaryk – volume: 301 start-page: 119 issue: 2 year: 2004 ident: ref15 article-title: Reactive oxygen species mediate RANK signaling in osteoclasts publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2004.07.035 contributor: fullname: H Ha – volume: 39 start-page: 775 issue: 2 year: 2016 ident: ref9 article-title: Resveratrol Protects against Titanium Particle-Induced Aseptic Loosening Through Reduction of Oxidative Stress and Inactivation of NF-kappaB publication-title: Inflammation doi: 10.1007/s10753-016-0306-6 contributor: fullname: G Luo – volume: 71 start-page: 111 issue: 2 year: 2000 ident: ref1 article-title: Long-term registration has improved the quality of hip replacement: a review of the Swedish THR Register comparing 160,000 cases publication-title: Acta Orthop Scand doi: 10.1080/000164700317413067 contributor: fullname: P Herberts – volume: 85 start-page: 632 issue: 3 year: 1990 ident: ref20 article-title: Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo publication-title: J Clin Invest doi: 10.1172/JCI114485 contributor: fullname: IR Garrett – volume: 93 start-page: 456 issue: 4 year: 2011 ident: ref3 article-title: Influence of patient activity on femoral osteolysis at five and ten years following hybrid total hip replacement publication-title: J Bone Joint Surg Br doi: 10.1302/0301-620X.93B4.25868 contributor: fullname: A Lubbeke – volume: 24 start-page: 55 issue: 1 year: 2006 ident: ref11 article-title: Role of free radicals in aseptic loosening of hip arthroplasty publication-title: J Orthop Res doi: 10.1002/jor.20013 contributor: fullname: P Kinov – volume: 25 start-page: 3511 issue: 17 year: 2004 ident: ref24 article-title: The influence of molecular weight, crosslinking and counterface roughness on TNF-alpha production by macrophages in response to ultra high molecular weight polyethylene particles publication-title: Biomaterials doi: 10.1016/j.biomaterials.2003.10.054 contributor: fullname: JH Ingram – volume: 2 start-page: 93 issue: 10 year: 2011 ident: ref5 article-title: Role of polyethylene particles in peri-prosthetic osteolysis: A review publication-title: World J Orthop doi: 10.5312/wjo.v2.i10.93 contributor: fullname: GJ Atkins – volume: 34 start-page: 3559 issue: 14 year: 2013 ident: ref12 article-title: Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.01.085 contributor: fullname: VK Raghunathan – volume: 73 start-page: 416 issue: 4 year: 2002 ident: ref36 article-title: Effect of submicron polyethylene particles on an osseointegrated implant: an experimental study with a rabbit patello-femoral prosthesis publication-title: Acta Orthop Scand doi: 10.1080/00016470216314 contributor: fullname: M Sundfeldt – volume: 17 start-page: 286 year: 2016 ident: ref29 article-title: Treatment of critically sized femoral defects with recombinant BMP-2 delivered by a modified mPEG-PLGA biodegradable thermosensitive hydrogel publication-title: BMC Musculoskelet Disord doi: 10.1186/s12891-016-1131-7 contributor: fullname: KT Peng – volume: 77 start-page: 177 issue: 2 year: 2006 ident: ref4 article-title: Aseptic loosening, not only a question of wear: a review of different theories publication-title: Acta Orthop doi: 10.1080/17453670610045902 contributor: fullname: M Sundfeldt – volume: 285 start-page: 6913 issue: 10 year: 2010 ident: ref17 article-title: RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis publication-title: J Biol Chem doi: 10.1074/jbc.M109.051557 contributor: fullname: MS Kim – volume: 6 start-page: 3595 issue: 9 year: 2010 ident: ref33 article-title: Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements publication-title: Acta Biomater doi: 10.1016/j.actbio.2010.04.010 contributor: fullname: E Zolotarevova |
SSID | ssj0053866 |
Score | 2.382949 |
Snippet | Small wear particles (0.1-10 μm) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and... Small wear particles (0.1-10 [mu]m) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and... Small wear particles (0.1–10 μm) in total joint replacement are generally considered as the major causative agent leading to periprosthetic inflammation and... |
SourceID | plos doaj pubmedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | e0202501 |
SubjectTerms | Animals Antioxidants Artificial joints Biocompatibility Bioindicators Biology and Life Sciences Biomedical materials Blood plasma Bone surgery Bone-Implant Interface Care and treatment Complications and side effects Dose-response effects Drug dosages Enzymes Exercise Gene expression Glutathione Peroxidase - metabolism Hip replacement arthroplasty Hospitals IL-1β Implantation Implants, Experimental - adverse effects Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Interleukin-1beta - metabolism Joint diseases Knee Knee replacement arthroplasty Male Malondialdehyde Malondialdehyde - metabolism Markers Medicine and Health Sciences NF-kappa B - metabolism NF-κB protein Orthopedics Osteoclasts - metabolism Osteoclasts - pathology Osteolysis Osteolysis - chemically induced Osteolysis - metabolism Osteolysis - pathology Oxidative Stress Particle Size Particulate matter Particulates Physical activity Polyethylene Polyethylene - adverse effects Polyethylenes Prostheses Proteins RANK Ligand - metabolism Rats Rats, Wistar Superoxide dismutase Superoxide Dismutase - metabolism Surgery Surgical implants TRANCE protein Wear particles |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF6hnLggyquBtiwICTi4jdf2rvdYHlVBAiSgqDdrvY82UrEtnEhNfz3frjdRjSrBgUsiZcd2MjM7840y8y0hL4BZMy5VmZR1qpPcyCxRpUsTK5lysDjn4bi3T5_58Un-8bQ4vXbUl-8JG-iBB8UdpExZp0vDuXC5c1lZI-ciTQutUomoEaJvWqyLqSEGYxdzHgflMpEeRLvsd21j9wGQkPfTUSIKfP2bqDzpLtr-Jsj5Z-fktVR0dJfciRiSHg7ffYvcss09shV3aU9fRSrp1_fJ1bsVnhxOm7eG2svY9drQ1lHl-xwv5wbv1DZXq5-4dN7Qrr1YWVgP2cjSLuonQeUOHzDU8yJ3flDk3A8_Qt7Bo4bpR9zQUD8y0gaWkwfk5Oj997fHSTxtIdFcskXiSldkMtcz5VSpAYtUrkVtXM1kPdNKGYuApDlXRnFgXc6cAhrLZrlyVjqgoIdk0kC_24QWbiaES02JcJAXluOlNNYhuAhRMyGnJFmrvuoGUo0q_LMmUIwMOqy8qapoqil54-2zkfWU2OEDOEoVFVH9zVGm5Km3bjXMl242dnWIGk0CRXE2Jc-DhKfFaHzfzZla9n314cuPfxD69nUk9DIKuRZ-olWcdcBv8nRbI8mdkSQ2tx4tb3tfXGulr5jvoxWoEQWuXPvnzcvPNsv-pr6XrrHtMsgArkDXkHk0uPNGswj3rMgYVsTI0UeqH6808_PASg4cjmqiePw_bPWE3AYw9dTpiOI7ZLL4tbS7AH-Lei_s89_Vu1w8 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Public Health Database dbid: 8C1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Jb9QwFLZguHBBlK1DCwSEBBxSJpuXEyqFqiABElDUW-R4aUcqSdrMSJ3-ej47nkBQhbhMpPFzZvI2f47fQshzYNaMCsljXiUqzrXIYsltEhuRSguJU-rbvX36TA8O849HxVF44daFsMq1T_SOWjfKvSPHJl2440bK2Zv2LHZdo9zpamihcZ3cSKCYrnUD3xtCPGDLlIZ0uYwlr4N0dtqmNjuASZiQjJYjX7V_8M2T9rTprgKef8dP_rEg7d8mtwKSjHZ70W-Qa6a-QzaCrXbRy1BQ-tVdcvluhV_2PeeNjsxFiH2to8ZG0kU7Xsw1rpGpL1c_MXVeR21zujKQIdYkE7VBvWLs36EJOnLVkVuXLnLiUiBBb6FXfQ4kbqgjlzjS-Fon98jh_vvvewdx6LkQKyrSRWy5LTKRq5m0kiuAI5krVmlbpaKaKSm1gVtSlEotKRAvTa0EJstmubRGWGCh-2RSg7-bJCrsjDGbaA6nkBeG4oNrY-FiGKtSJqYkXrO-bPvSGqU_X2PYkvQ8LJ2oyiCqKXnr5DPQusLY_ovm_LgMjCiTVBqruKaU2dzajFeAaEB1TMlEYJGZkidOumWfZTqYd7mLnZoAlqLplDzzFK44Ru2ib47lsuvKD19-_AfRt68joheByDbQEyVDxgOeyRXdGlFujyhh4mo0vOl0cc2VrvxtDJi51s-rh58Ow-6mLqKuNs3S0wC0gNegedCr88BZOP20yFKMsJGij1g_HqnnJ742OdA49hTFw3__rS1yE8DTlUaHl94mk8X50jwCuFtUj70F_wJQjVKi priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1ba9RAFB7KCtIXsd66teoogvqQsrnNJA8i9VKqUAV1pW9hMpd2YU3iZhd2--v9JpmERrbgyy7snJmw5zbfIedCyEtg1pClIvGS3JdepNLQE4nxPZ0GwkDijDXj3s6-stNp9OU8Pt8h3cxWx8B6a2hn50lNF_Oj9Z_NOxj822ZqA_e7TUdVWegjwB_c6oiHbgVRGFmdP4v69wqwbsZcAd1NO3fJbSh9EId20My1u6pp6d877lE1L-ttqPTf5Mprt9XJXXLHwUx63OrFHtnRxT2y5wy5pq9dt-k398nVxw2e3Ayk14rqtUuMLWhpqLCpkOuZwjfVxdXmN7bOClqV842GgHFhaVo53fMQ3ENNFLWtkytbS3Jp6yNBb6B0bYEkDlTUVpWUTSOUB2R68unnh1PPDWTwJEuDpWcSE4dpJCfCiEQCOYlI8lyZPEjziRRCafgsyZhQggEOs8AIALZwEgmjUwOg9JCMCrB6n9DYTDg3vkrgMaJYM3wkShv4H87zgKdj4nWsz6q270bWvHzjiFdaHmZWapmT2pi8t_LpaW3X7OaHcnGROUZkfiC0kYlijJvImDDJgd8A-bgUfoobaEyeWelmbQlqb_vZMcK4FECLBWPyoqGwnTMKm5pzIVZ1nX3-9us_iH58HxC9ckSmhJ5I4coh8J9sR64B5eGAEvYvB8v7Vhc7rtRZYFNtOcJIjp2dfm5fft4v20Ntul2hy1VDA0QDXoPmUavOPWc74xgTPlD0AeuHK8XssmlcDqiOgCM-uPHMx2QXgNS2TIf3PiSj5WKlnwD0LfOnjR3_BTtBWF4 priority: 102 providerName: Scholars Portal |
Title | Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis |
URI | https://www.ncbi.nlm.nih.gov/pubmed/30125327 https://www.proquest.com/docview/2090277687 https://search.proquest.com/docview/2091233717 https://pubmed.ncbi.nlm.nih.gov/PMC6101395 https://doaj.org/article/12aefc8d667f4ff38b6175607ca19eac http://dx.doi.org/10.1371/journal.pone.0202501 |
Volume | 13 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2cuGCGF_rGCUgJOCQtvmyk-NWVgZSxzQY6i1yHHur1CbR2krr_np-dpxqQTsgLq5UPyfN-_y5ee-ZkA_ArAFNeOzGmSfcME8Cl8fKc2XicwWJU2qOe5uc0dPL8Ps0mu6QqKmFMUn7Ipv1i_miX8yuTW5ltRCDJk9scD4ZIeQDuESDXbLLgqDZotfuFwZMqa2RC5g3sCLpV2Uh-8BGCPn6dBjotR8F-iyZe-HIdO3f-uZONS-XDwHPv_Mn7wWk8VPyxCJJ56j-xXtkRxbPyJ611aXzyTaU_vyc3H3Z4M7mzHmZO_LW5r4WTqkcrrMdb2c5Ph1Z3G0WWDornKqcbyRkiJgkncpyxcX-HZqQO7o7cqXLRa51CSToFfSqroHEBXNHF46UptfJC3I5Pvk1OnXtmQuuoIm_clWsoiAJxZArHguAIx4KluUq85NsKDjPJdySoJTnnALxUl9xYLJgGHIlEwUs9JJ0CrB6nziRGjKmvDyGUwgjSTHEuVRwMYxlPku6xG1Yn1Z1a43UvF9j2JLUPEy11FIrtS451vLZ0urG2OaL8uYqtYxIPZ9LJeKcUqZCpYI4A0QDqmOCewmCTJe81dJN6yrTrXmnR9ipJcBS1O-S94ZCN8codPbNFV8vl-m3H7__gejnRYvooyVSJfREcFvxgGfSTbdalIctSpi4aE3va11suLJMfZ1Ny7BTZFjZ6OfD0--20_qiOqOukOXa0AC0gNegeVWr85azjXF0CWspeov17RmYqulNbk3z4L9XviaPgUl113Q48EPSWd2s5RvgvlXWg7VPGcZ45Olx_LVHHh2fnJ1f9Mw_KRgnYdwz3uAP5NNhtQ |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,12083,12250,12792,21416,24346,27955,27956,31752,31753,33299,33300,33406,33407,33777,33778,43343,43612,43633,43838,53825,53827,74100,74369,74390,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLage4AXxLitMFhASMBDRnOz4ye0waYOtoLGNu0tcnzZKo0kLK207tfzOXEKQRPipZXqk7Q9N3-Oz_lMyGtg1ohykfppHkg_VjzyRWoCX_NQGFic0ua4t4MJHR_Hn0-TU_fArXZllV1ObBK1KqV9Ro5FOrfbjTRlH6qfvj01yu6uuiM0bpMVS7mZDsjK9s7k22GXixHNlLqGuYgF7519Nquy0JsASpj_g96E1PD2L7PzoLoo65ug598VlH9MSbv3yT2HJb2t1vir5JYuHpBVF62199ZRSr97SK4_LfDNzanzWnn6ylW_Fl5pPGHrHa-mCu-eLq4XP3DptPCq8mKhYUXMStqrnIP5WMHDF5Rn-ZEr2zBybpsgIW_gWW0XJG6oPNs6UjZsJ4_I8e7O0cex705d8CXl4cw3qUkiHsuRMCKVgEcilixXJg95PpJCKI3EJCkVSlBgXhoaAVQWjWJhNDdAQ4_JoIB-14iXmBFjJlAp0kKcaIqXVGmDJMNYHjI-JH6n-qxqyTWyZoeNYVHS6jCzpsqcqYZk29pnKWupsZsPysuzzCkiC0KhjUwVpczExkRpDpAGXMekCDimmSHZsNbN2j7TZYBnW1ircaApGg7Jq0bC0mMUtv7mTMzrOtv7evIfQt8Pe0JvnJAp4SdSuJ4H_CdLu9WTXO9JIshlb3jN-mKnlTr7HQ64svPPm4dfLoftTW1NXaHLeSMD2AJdQ-ZJ685LzSLth0kUYoT1HL2n-v5IMT1v2MmBx7GqSJ7--2dtkDvjo4P9bH9v8uUZuQsYaonSkbPXyWB2OdfPAfVm-QsXz78AlSxXNg |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Zb9NAEF5BkBAviHI1UKhBSMCD2_ja4wmVlqrlKAho1TdrvUcbqdimTqSmv55v7Y3BqEK8JFJmbCdzfpudmSXkBTBrQoXkIS8iFaZaJKHkNgqNiKWFxiltj3v7dED3DtP3x9mxr39qfFnlMia2gVpXyv1HjkW6cNuNlLNN68sivuzsvql_hu4EKbfT6o_TuE5uICtSZ-F8uy_3gF9T6lvnEhZtek1t1FVpNgCZgASiQWpqJ_j3cXpUn1XNVSD071rKP5LT7h1y26PKYKszgxVyzZR3yYr32yZ45YdLv75HLncWeHJ7_rzRgbnwdbBlUNlAusrHi6nGe2DKy8UPXDotg7o6WxjoE_nJBLU3tRBreViFDtyk5Nq1jpy6dkjwW9hY1w-JG-rANZFU7dyT--Rw99337b3Qn78QKiriWWi5zRKRqom0kisAJZkqVmhbxKKYKCm1QYhSlEotKdAvja0EPksmqbRGWOCiB2RUQr6rJMjshDEbaY4AkWaG4oVrYxFuGCtiJsYkXIo-r7sxG3m718awPOlkmDtV5V5VY_LW6afndUOy2w-q85PcCyKPYmms4ppSZlNrE14ArgHhMSUjgYQzJutOu3nXcdq7er6FVZsArqLxmDxvOdygjNKZ3ImcN02-__noP5i-fR0wvfRMtoKdKOm7H_Cb3ACuAefagBPurgbkVWeLS6k0-W_HwJVL-7ya_Kwnu5u66rrSVPOWBwAGsgbPw86ce8kiAcRZEoPCBoY-EP2QUk5P2znlQOZYX2SP_v211slNOHL-cf_gw2NyC3jUTUxH8F4jo9n53DwB5psVT1tn_gWHBVnQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dysregulated+expression+of+antioxidant+enzymes+in+polyethylene+particle-induced+periprosthetic+inflammation+and+osteolysis&rft.jtitle=PloS+one&rft.au=Peng%2C+Kuo-Ti&rft.au=Tsai%2C+Meng-Hsueh&rft.au=Lee%2C+Chiang-Wen&rft.au=Chiang%2C+Yao-Chang&rft.date=2018-08-20&rft.eissn=1932-6203&rft.volume=13&rft.issue=8&rft.spage=e0202501&rft_id=info:doi/10.1371%2Fjournal.pone.0202501&rft_id=info%3Apmid%2F30125327&rft.externalDocID=30125327 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |