Long-term visual acuity in patients with optic pathway glioma treated during childhood with up-front BB-SFOP chemotherapy—Analysis of a French pediatric historical cohort

• Published in: PloS one Vol. 14; no. 3; p. e0212107
• Main Authors: Rakotonjanahary, Josué, Gravier, Nicolas, Lambron, Julien, De Carli, Emilie, Toulgoat, Frédérique, Delion, Matthieu, Pellier, Isabelle, Rialland, Xavier
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.03.2019; Public Library of Science (PLoS)
• Subjects: Acuity; Adolescent; Analysis; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biology and Life Sciences; Brain cancer; Brain research; Cancer; Cancer treatment; Carboplatin - administration & dosage; Carboplatin - therapeutic use; Care and treatment; Chemotherapy; Child; Child, Preschool; Childhood; Children; Cohort Studies; Complications and side effects; Drug Therapy - methods; Female; Follow-Up Studies; France; Glioma; Glioma - therapy; Gliomas; Hospitals; Humans; Hypertension; Intracranial hypertension; Low vision; Male; Medical prognosis; Medicine and Health Sciences; Multivariate analysis; NMR; Nuclear magnetic resonance; Oncology; Optic Nerve Glioma - therapy; Patients; Pediatric research; Pediatric tumors; Pediatrics; Prognosis; Radiation therapy; Regression analysis; Research and Analysis Methods; Retrospective Studies; Risk factors; Social Sciences; Studies; Surgery; Treatment outcome; Tumors; Vincristine - therapeutic use; Vision; Vision Disorders - etiology; Visual acuity; Visual Acuity - physiology; Visual aspects; Visual impairment; France

Visual outcome is one of the main issues in the treatment of optic pathway glioma in childhood. Although the prognostic factors of low vision have been discussed extensively, no reliable indicators for visual loss exist. Therefore, we aimed to define initial and evolving factors associated with long...