Sequence Variation Analysis of HPV-18 Isolates in Southwest China

• Published in: PloS one Vol. 8; no. 2; p. e56614
• Main Authors: Shen, Mengjie, Ding, Xianping, Li, Tianjun, Chen, Gangyi, Zhou, Xiao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.02.2013; Public Library of Science (PLoS)
• Subjects: Adenoviruses; Amino acids; Analysis; Biology; Carcinogenesis; Carcinogens; Cervical cancer; Cervix; China; Deoxyribonucleic acid; Development and progression; Diagnostic systems; DNA; DNA probes; DNA, Viral - genetics; Female; Gene expression; Gene sequencing; Genetic research; Genetics; Genomes; Genomics; Health aspects; Human papillomavirus; Human papillomavirus 18 - genetics; Humans; In Vitro Techniques; Infections; Laboratories; Lesions; Life sciences; Medicine; Mutation; Papillomavirus infections; Polymerase Chain Reaction; Proteins; Sequence Analysis, DNA - methods; Transversion; Tumorigenesis; Uterine Cervical Neoplasms - microbiology; Vaccines; Variation; Virology; China

Intratypic variations of HPV-18 are known to differ in the persistence of the infection, frequency of carcinogenesis and the progression of precursor lesions to advanced cervical cancer. This study was designed to analyze sequence variations of HPV-18 isolates in order to discover novel HPV-18 varia...