Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial
Introduction Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM. Methods This was a multicenter, prospective, double-b...
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Published in | Diabetology international Vol. 13; no. 1; pp. 209 - 219 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Singapore
Springer Singapore
01.01.2022
Springer Nature B.V |
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Abstract | Introduction
Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM.
Methods
This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2′-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated.
Results
There were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed.
Conclusion
There were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients. |
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AbstractList | Introduction
Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM.
Methods
This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2′-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated.
Results
There were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed.
Conclusion
There were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients. INTRODUCTIONElectrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM.METHODSThis was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2'-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated.RESULTSThere were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed.CONCLUSIONThere were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients.SUPPLEMENTARY INFORMATIONThe online version contains supplementary material available at 10.1007/s13340-021-00524-3. Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM. This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2'-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated. There were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed. There were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients. The online version contains supplementary material available at 10.1007/s13340-021-00524-3. IntroductionElectrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM.MethodsThis was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2′-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated.ResultsThere were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed.ConclusionThere were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients. |
Author | Kabayama, Shigeru Ohsaki, Yusuke Ogawa, Susumu Tabata, Kiyoshi Tanaka, Yasuhisa Okamura, Masashi Ito, Sadayoshi Shimizu, Manami Nako, Kazuhiro |
Author_xml | – sequence: 1 givenname: Susumu orcidid: 0000-0001-5489-9259 surname: Ogawa fullname: Ogawa, Susumu email: ogawa-s@hosp.tohoku.ac.jp organization: Division of Research in Student Support, Section of Clinical Medicine, Institute for Excellence in Higher Education, Tohoku University, Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine – sequence: 2 givenname: Yusuke surname: Ohsaki fullname: Ohsaki, Yusuke organization: Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Nihon Trim Co., Ltd – sequence: 3 givenname: Manami surname: Shimizu fullname: Shimizu, Manami organization: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital – sequence: 4 givenname: Kazuhiro surname: Nako fullname: Nako, Kazuhiro organization: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine – sequence: 5 givenname: Masashi surname: Okamura fullname: Okamura, Masashi organization: Tohoku Central Hospital – sequence: 6 givenname: Shigeru surname: Kabayama fullname: Kabayama, Shigeru organization: Nihon Trim Co., Ltd – sequence: 7 givenname: Kiyoshi surname: Tabata fullname: Tabata, Kiyoshi organization: Iwate Prefectural Takata Hospital – sequence: 8 givenname: Yasuhisa surname: Tanaka fullname: Tanaka, Yasuhisa organization: Tohoku Central Hospital – sequence: 9 givenname: Sadayoshi surname: Ito fullname: Ito, Sadayoshi organization: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine |
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Snippet | Introduction
Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes... Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM)... IntroductionElectrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes... INTRODUCTIONElectrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes... |
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StartPage | 209 |
SubjectTerms | Antioxidants Clinical trials Deoxyguanosine Diabetes Diabetes mellitus (non-insulin dependent) Double-blind studies Endocrinology Homeostasis Insulin Insulin resistance Lactic acid Medicine Medicine & Public Health Metabolic Diseases Original Original Article Oxidative stress Patients Plasma |
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Title | Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial |
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