Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal

• Published in: PloS one Vol. 8; no. 11; p. e81387
• Main Authors: Boisvert, Rebecca A, Rego, Meghan A, Azzinaro, Paul A, Mauro, Maurizio, Howlett, Niall G
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2013; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Amino acids; Anemia; Animals; Birth defects; Bone cancer; Bone marrow; Breast cancer; Cancer; Cell Line; Cell Nucleus - metabolism; Chromatin; Chromatin - metabolism; Congenital defects; Conserved Sequence; Crosslinking; Defects; Deoxyribonucleic acid; Disease susceptibility; DNA; DNA Damage; DNA repair; FANCD2 protein; Fanconi Anemia - genetics; Fanconi Anemia - metabolism; Fanconi Anemia Complementation Group D2 Protein - chemistry; Fanconi Anemia Complementation Group D2 Protein - genetics; Fanconi Anemia Complementation Group D2 Protein - metabolism; Fanconi Anemia Complementation Group Proteins - metabolism; Fanconi syndrome; Fanconi's anemia; Genes; Genetic aspects; Humans; Localization; Models, Biological; Molecular biology; Molecular Sequence Data; Mutants; Mutation; Nuclear Localization Signals - chemistry; Nuclear Localization Signals - genetics; Nuclear transport; Protein Transport; Proteins; Repair; Sequence Alignment; Structure-function relationships; Ubiquitination; Womens health; Rhode Island

Fanconi anemia (FA) is a rare recessive disease, characterized by congenital defects, bone marrow failure, and increased cancer susceptibility. FA is caused by biallelic mutation of any one of sixteen genes. The protein products of these genes function cooperatively in the FA-BRCA pathway to repair...