Effects of low-to-moderate ethanol consumption on colonic growth and gene expression in young adult and middle-aged male rats

• Published in: PloS one Vol. 15; no. 12; p. e0243499
• Main Authors: Wells, Nicole, Quigley, Jacqueline, Pascua, Jeremy, Pinkowski, Natalie, Almaiman, Lama, Brasser, Susan M., Hong, Mee Young
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.12.2020; Public Library of Science (PLoS)
• Subjects: Aging; Alcohol; Alcohol use; Alcohol, Denatured; Animals; Apoptosis; Apoptosis - drug effects; Biology and Life Sciences; Cancer; Cell cycle; Cell differentiation; Cell Differentiation - drug effects; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Colon; Colon - cytology; Colon - metabolism; Colon - pathology; Colorectal cancer; Colorectal carcinoma; Cyclin D1; Cyclin D1 - genetics; Cyclin D1 - metabolism; Cyclin-dependent kinase 2; Cyclin-Dependent Kinase 2 - genetics; Cyclin-Dependent Kinase 2 - metabolism; Cyclin-dependent kinase 4; Cyclin-dependent kinase inhibitor p21; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Cyclin-dependent kinases; Diet; Differentiation (biology); Drinking of alcoholic beverages; E-cadherin; Epidemiology; Ethanol; Ethanol - pharmacology; Exercise; Gene expression; Gene Expression - drug effects; Health aspects; Health risks; Kinases; Laboratories; Male; Medicine and Health Sciences; Middle age; Mucosa; Older people; p53 Protein; Parameters; Physical fitness; Physical Sciences; Polymerase chain reaction; Rats; Rats, Wistar; Risk analysis; Risk factors; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumorigenesis; Water control; Women; Young adults; United States; United States > US

Excessive alcohol consumption is a risk factor associated with colorectal cancer; however, some epidemiological studies have reported that moderate alcohol consumption may not contribute additional risk or may provide a protective effect reducing colorectal cancer risk. Prior research highlights the...