Dipeptidyl-Peptidase IV Activity Is Correlated with Colorectal Cancer Prognosis

• Published in: PloS one Vol. 10; no. 3; p. e0119436
• Main Authors: Larrinaga, Gorka, Perez, Itxaro, Sanz, Begoña, Beitia, Maider, Errarte, Peio, Fernández, Ainhoa, Blanco, Lorena, Etxezarraga, María C., Gil, Javier, López, José I.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.03.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Apoptosis; Apoptosis - genetics; Basque people; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Cancer; Cell differentiation; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - blood; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Dipeptidyl Peptidase 4 - biosynthesis; Dipeptidyl Peptidase 4 - blood; Dipeptidyl Peptidase 4 - genetics; Dipeptidyl-peptidase IV; Disease-Free Survival; Early Detection of Cancer; Enzymes; Female; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Immunomodulation; Male; Medical prognosis; Middle Aged; mRNA; Mucosa; Neoplasia; Neoplasms; Patients; Polymerase chain reaction; Prognosis; RNA; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Serine; Serine peptidase; Studies; Survival; Tissues; Transformation; Transformations (mathematics); Tumors; Spain

Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. Previous studies have demonstrated altered expression and activity of tissue and circulating DPPIV in sev...