The zebrafish orthologue of familial Alzheimer’s disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation

• Published in: PloS one Vol. 13; no. 10; p. e0206155
• Main Authors: Jiang, Haowei, Newman, Morgan, Lardelli, Michael
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.10.2018; Public Library of Science (PLoS)
• Subjects: Adults; Age; Aging; Alzheimer's disease; Amino acids; Biology and Life Sciences; Brain; Coding; Codons; CRISPR; Danio rerio; Dementia; Dementia disorders; Epithelium; Flavin-adenine dinucleotide; Gene expression; Gene mutation; Genes; Genetic aspects; Genetics; Genome editing; Genomes; Genomics; Homozygotes; Hypoxia; Laboratories; Larvae; Mammals; Mutation; Neural coding; Physiological aspects; Pigmentation; Presenilin 2; Proteins; Research and Analysis Methods; Retina; Retinal pigment epithelium; Risk factors; Secretase; Signal transduction; Skin diseases; Skin pigmentation; Zebrafish; Australia; South Australia Australia

Alzheimer's disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause familial Alzheimer's disease (fAD). Zebrafish possess an orthologous gene, psen2, and present opportunities for investigation of PRESEN...