T cell subtypes and reciprocal inflammatory mediator expression differentiate P. falciparum memory recall responses in asymptomatic and symptomatic malaria patients in southeastern Haiti

• Published in: PloS one Vol. 12; no. 4; p. e0174718
• Main Authors: Lehmann, Jason S., Campo, Joseph J., Cicéron, Micheline, Raccurt, Christian P., Boncy, Jacques, Beau De Rochars, Valery E. M., Cannella, Anthony P.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.04.2017; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Adaptive Immunity - immunology; Adolescent; Adult; Analysis; Arthritis; Asymptomatic Infections - epidemiology; Biology and Life Sciences; Care and treatment; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes - immunology; Chemokines; Cross-Sectional Studies; Cytokines; Erythrocytes; Erythrocytes - parasitology; Female; Growth factors; Haiti - epidemiology; Human populations; Humans; Immune response; Immunoglobulin G - immunology; Immunoglobulin M - immunology; Immunology; Infections; Infectious diseases; Inflammation; Inflammation - immunology; Inflammation Mediators - metabolism; Lymphocytes T; Malaria; Malaria, Falciparum - epidemiology; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; Male; Medicine; Medicine and Health Sciences; Microscopy; Middle Aged; Monocytes; Parasites; Pathogens; People and places; Physiological aspects; Plasmodium falciparum; Plasmodium falciparum - immunology; Population; Principal components analysis; Protein Array Analysis; Protozoan Proteins - immunology; Public health; Recall; T cells; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Regulatory - immunology; Vector-borne diseases; Young Adult; Haiti; Florida; United States > US; Port Au Prince Haiti

Asymptomatic Plasmodium falciparum infection is responsible for maintaining malarial disease within human populations in low transmission countries such as Haiti. Investigating differential host immune responses to the parasite as a potential underlying mechanism could help provide insight into this...