Graphical and statistical analyses of the oculocardiac reflex during a non-invasive intracranial pressure measurement

This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive int...

Full description

Saved in:

Bibliographic Details
Published in	PloS one Vol. 13; no. 4; p. e0196155
Main Authors	Hamarat, Yasin, Bartusis, Laimonas, Deimantavicius, Mantas, Siaudvytyte, Lina, Januleviciene, Ingrida, Ragauskas, Arminas, Bershad, Eric M., Fandino, Javier, Kienzler, Jenny, Remonda, Elke, Matijosaitis, Vaidas, Rastenyte, Daiva, Petrikonis, Kestutis, Berskiene, Kristina, Zakelis, Rolandas
Format	Journal Article
Language	English
Published	United States Public Library of Science 19.04.2018 Public Library of Science (PLoS)
Subjects	Adult Aged Analysis Anesthesia Biology and Life Sciences Data Interpretation, Statistical Diagnostic Techniques and Procedures - instrumentation External pressure Female Flow velocity Glaucoma Health aspects Health sciences Heart Rate Humans Incidence Intracranial Pressure Male Measurement Measurement techniques Medicine and Health Sciences Middle Aged Models, Statistical Neurology Neurosurgery Physiological aspects Physiological research Pressure Pressure measurement Reflex, Oculocardiac Reflexes Statistical analysis Surgery Telematics Ultrasonic transducers Veins & arteries Young Adult Lithuania United States > US Switzerland Texas
Online Access	Get full text
ISSN	1932-6203 1932-6203
DOI	10.1371/journal.pone.0196155

Cover

More Information
Summary:	This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex. None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient. The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: Professor Arminas Ragauskas is an inventor of patented the non-invasive ICP measurement method and a shareholder of Vittamed Neuroscience (Waltham, MA, USA). Arminas Ragauskas, Laimonas Bartusis, Mantas Deimantavicius and Rolandas Zakelis have received financial support from Vittamed Neuroscience (Waltham, MA, USA). Clinical studies were funded by the: European Commission’s Seventh Framework Programme project ‘BrainSafe’ (grant no. 232545), Lithuanian-Swiss Programe project ‘BrainCare’ (grant no. CH-3SMM01/06), European Social Fund under the Global Grant measure (grant no. VP1-3.1-SMM-07-K-03-080), National Space Biomedical Research Institute via NASA NCC9-58, and Center for Space Medicine, Baylor College of Medicine. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0196155