Graphical and statistical analyses of the oculocardiac reflex during a non-invasive intracranial pressure measurement

This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive int...

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Published inPloS one Vol. 13; no. 4; p. e0196155
Main Authors Hamarat, Yasin, Bartusis, Laimonas, Deimantavicius, Mantas, Siaudvytyte, Lina, Januleviciene, Ingrida, Ragauskas, Arminas, Bershad, Eric M., Fandino, Javier, Kienzler, Jenny, Remonda, Elke, Matijosaitis, Vaidas, Rastenyte, Daiva, Petrikonis, Kestutis, Berskiene, Kristina, Zakelis, Rolandas
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 19.04.2018
Public Library of Science (PLoS)
Subjects
Adult
Aged
Analysis
Anesthesia
Biology and Life Sciences
Data Interpretation, Statistical
Diagnostic Techniques and Procedures - instrumentation
External pressure
Female
Flow velocity
Glaucoma
Health aspects
Health sciences
Heart Rate
Humans
Incidence
Intracranial Pressure
Male
Measurement
Measurement techniques
Medicine and Health Sciences
Middle Aged
Models, Statistical
Neurology
Neurosurgery
Physiological aspects
Physiological research
Pressure
Pressure measurement
Reflex, Oculocardiac
Reflexes
Statistical analysis
Surgery
Telematics
Ultrasonic transducers
Veins & arteries
Young Adult
Lithuania
United States > US
Switzerland
Texas
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0196155

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Abstract This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex. None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient. The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
AbstractList This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient. The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
Purpose This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Methods Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex. Results None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient. Conclusion The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex. None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient. The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye.PURPOSEThis study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye.Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex.METHODSPatients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex.None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient.RESULTSNone of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient.The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.CONCLUSIONThe incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye.Patients (n = 101) and healthy volunteers (n = 56) aged 20-75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex.None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient.The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
Purpose This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was applied to the orbital tissues and eye. Methods Patients (n = 101) and healthy volunteers (n = 56) aged 20–75 years who underwent a non-invasive intracranial pressure measurement were included in this retrospective oculocardiac reflex analysis. Prespecified thresholds greater than a 10% or 20% decrease in the heart rate from baseline were used to determine the incidence of the oculocardiac reflex. Results None of the subjects had a greater than 20% decrease in heart rate from baseline. Four subjects had a greater than 10% decrease in heart rate from baseline, representing 0.9% of the total pressure steps. Three of these subjects were healthy volunteers, and one was a glaucoma patient. Conclusion The incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement procedure was very low and not associated with any clinically relevant effects.
Audience Academic
Author Petrikonis, Kestutis
Ragauskas, Arminas
Zakelis, Rolandas
Deimantavicius, Mantas
Matijosaitis, Vaidas
Kienzler, Jenny
Remonda, Elke
Rastenyte, Daiva
Fandino, Javier
Bartusis, Laimonas
Hamarat, Yasin
Januleviciene, Ingrida
Bershad, Eric M.
Siaudvytyte, Lina
Berskiene, Kristina
AuthorAffiliation 4 Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
5 Department of Neurology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Oregon Health and Science University, UNITED STATES
2 Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
6 Sports Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania
3 Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America
1 Health Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29672564$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_2147_OPTH_S317447
crossref_primary_10_3390_jcm12062209
crossref_primary_10_3390_medicina56120664
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2018 Hamarat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2018 Hamarat et al 2018 Hamarat et al
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– notice: 2018 Hamarat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Competing Interests: Professor Arminas Ragauskas is an inventor of patented the non-invasive ICP measurement method and a shareholder of Vittamed Neuroscience (Waltham, MA, USA). Arminas Ragauskas, Laimonas Bartusis, Mantas Deimantavicius and Rolandas Zakelis have received financial support from Vittamed Neuroscience (Waltham, MA, USA). Clinical studies were funded by the: European Commission’s Seventh Framework Programme project ‘BrainSafe’ (grant no. 232545), Lithuanian-Swiss Programe project ‘BrainCare’ (grant no. CH-3SMM01/06), European Social Fund under the Global Grant measure (grant no. VP1-3.1-SMM-07-K-03-080), National Space Biomedical Research Institute via NASA NCC9-58, and Center for Space Medicine, Baylor College of Medicine. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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Snippet This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external pressure was...
Purpose This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external...
Purpose This study aimed to examine the incidence of the oculocardiac reflex during a non-invasive intracranial pressure measurement when gradual external...
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SubjectTerms Adult
Aged
Analysis
Anesthesia
Biology and Life Sciences
Data Interpretation, Statistical
Diagnostic Techniques and Procedures - instrumentation
External pressure
Female
Flow velocity
Glaucoma
Health aspects
Health sciences
Heart Rate
Humans
Incidence
Intracranial Pressure
Male
Measurement
Measurement techniques
Medicine and Health Sciences
Middle Aged
Models, Statistical
Neurology
Neurosurgery
Physiological aspects
Physiological research
Pressure
Pressure measurement
Reflex, Oculocardiac
Reflexes
Statistical analysis
Surgery
Telematics
Ultrasonic transducers
Veins & arteries
Young Adult
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Title Graphical and statistical analyses of the oculocardiac reflex during a non-invasive intracranial pressure measurement
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