Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers

• Published in: PloS one Vol. 9; no. 2; p. e88401
• Main Authors: Schleifman, Erica B, Desai, Rupal, Spoerke, Jill M, Xiao, Yuanyuan, Wong, Cheryl, Abbas, Ilma, O'Brien, Carol, Patel, Rajesh, Sumiyoshi, Teiko, Fu, Ling, Tam, Rachel N, Koeppen, Hartmut, Wilson, Timothy R, Raja, Rajiv, Hampton, Garret M, Lackner, Mark R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.02.2014; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; Adjuvant chemotherapy; AKT1 protein; Analysis; Bioindicators; Biology; Biomarkers; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cancer metastasis; Class I Phosphatidylinositol 3-Kinases; Diagnostic systems; Estrogen; Estrogen receptors; Estrogens; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Humans; Immunohistochemistry; Ki-67 Antigen - metabolism; Medical diagnosis; Medicine; Metabolome; Metastases; Microfluidics; Mutation; Mutation - genetics; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Paraffin; Patients; Phenols (Class of compounds); Phosphatidylinositol 3-Kinases - genetics; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN protein; Receptors; Receptors, Estrogen - metabolism; Recurrence (Disease); Reproducibility of Results; RNA; Signal Transduction; Signaling; Studies; Surgery; Therapy; Tumor Cells, Cultured; Tumors

Patients with newly diagnosed, early stage estrogen receptor positive (ER+) breast cancer often show disease free survival in excess of five years following surgery and systemic adjuvant therapy. An important question is whether diagnostic tumor tissue from the primary lesion offers an accurate mole...