Subclinical Elevation of Plasma C-Reactive Protein and Illusions/Hallucinations in Subjects with Parkinson’s Disease: Case–control Study

• Published in: PloS one Vol. 9; no. 1; p. e85886
• Main Authors: Sawada, Hideyuki, Oeda, Tomoko, Umemura, Atsushi, Tomita, Satoshi, Hayashi, Ryutaro, Kohsaka, Masayuki, Yamamoto, Kenji, Sudoh, Shinji, Sugiyama, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.01.2014; Public Library of Science (PLoS)
• Subjects: Amantadine; Amantadine - therapeutic use; Antibiotics; Bioethics; Brain research; Bronchitis; C-reactive protein; C-Reactive Protein - metabolism; Case-Control Studies; Clinical trials; Cognitive ability; Confidence intervals; Consent; Cross-Sectional Studies; Cytokines; Delusions - psychology; Dementia; Diagnosis; Dihydroxyphenylalanine; Disease; Disease control; Disorientation; Dopamine; Dopamine Agents - therapeutic use; Hallucinations; Hallucinations - psychology; Health aspects; Hospitals; Humans; Illusions; Illusions - psychology; Infection; Infections; Inflammation; Levodopa; Levodopa - therapeutic use; Logistic Models; Medical research; Medicine; Mental disorders; Movement disorders; Multivariate Analysis; Neurodegenerative diseases; Neurology; Parkinson Disease - blood; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Parkinson's disease; Patients; Plasma; Pneumonia; Proteins; Psychosis; Psychotic Disorders - psychology; Regression analysis; Regression models; Risk Factors; Selegiline; Selegiline - therapeutic use; Sleep; Sleep disorders; Social and Behavioral Sciences; Statistical analysis; Surveys and Questionnaires

Though infections are associated with psychotic symptoms, whether or not subclinical inflammation is associated with hallucinations is not known in Parkinson's disease (PD). To investigate the association of illusions/hallucinations and plasma CRP levels in PD patients without symptomatic infec...